Skip to main content

Prevalence of depression, anxiety, stress and its relationship with knowledge about COVID-19 in medical and laboratory medicine students of Umm-Al-Qura University: a cross-sectional survey



Coronavirus disease 2019 (COVID-19) pandemic has continued relentlessly for over one and half years now, causing a threat to life, fear of falling sick, helplessness, anxiety, depression and, pessimism about the future. There has been an increasing concern over student mental health in higher education. Our study was designed to measure current mental health status and its relationship with sociodemographic variables and level of knowledge about COVID-19 in Saudi Arabia.


A cross-sectional survey was conducted among laboratory medicine students of Makkah city, Saudi Arabia from October, 2020 to January, 21. A semi-structured questionnaire was circulated through mail and What’s App. Data collected included sociodemographic details and level of knowledge towards the COVID-19 among the students. Depression anxiety and stress-21 item (DASS 21) was used to assess psychological status.


Our study reported 51.4% depressive symptoms, 57.9% anxiety symptoms, and 48.5% stress in the study participants. History of being hospitalized with COVID-19 and ICU reported high anxiety (p = 0.0003) and depression scores (p = 0.04). Respiratory droplet as a mode of transmission revealed higher scores on anxiety subscale (p = 0.007), whereas surface contamination reported high score of stress (p = 0.004) and anxiety (p = 0.002). Knowing that COVID-19 can also clinically present with gastrointestinal symptoms was found to show high stress (p = 0.005) and anxiety (p = 0.01) scores than any other way of clinical presentation.


COVID-19 is likely to cause negative effect on the psychological health of students.


The novel coronavirus disease 2019 (“COVID-19”) has gripped the world, causing alarm and dread across the world. Since the start of the pandemic through December 1st, 2020, there have been 347,157 confirmed (Covid-19) cases in Saudi Arabia, with 5907 fatalities [1]. Most cross-sectional surveys [2,3,4,5,6] of the general population showed increased symptoms of depression, anxiety, and stress-related to “COVID-19” due to its lethality, drastic change in lifestyle, social isolation, economic burden and, pessimism about the future, fear and worry about contracting the illness [7]. Studies from the Kingdom of Saudi Arabia reported high levels of stress, anxiety and, depression among the general population [8,9,10] and in particular university students [10, 11] during the pandemic. A survey of the mental health of college students during the 2019–2020 academic year, both before and after the COVID-19 pandemic, found a startlingly high prevalence of depression and anxiety [11].

Health education transition from face-to-face sessions to video lectures or live streams [12] lead to the stress and anxiety [13]. Although lecture-based teaching is simply transitioned to an online format, clinical exposure and providing authentic patient experiences are not as easily replicated. Such circumstances have an adverse effect on the mental health of medical and paramedical students. Pre-pandemic evidence suggests that medical and paramedical students have reported higher levels of perceived stress, anxiety, and depression than general population [13], which further increased during the pandemic. Increased anxiety, depression [14, 15] PTSD [16] and stress [17] symptoms were found in college and university students. Although the institutional response to “COVID-19” has been rapid, with a commitment to deliver academic services uninterruptedly, such a sudden change may cause more stress for students who are already under high levels of academic stress [18].

Adequate knowledge about pandemic may show reduced negative impact (anxiety and stress) in vulnerable population [19, 20]. Recognizing the psychological impact of the “COVID-19” outbreak in the general population and high-risk population like students and health care workers is pivotal in guiding policymakers and formulating interventions to maintain positive mental health. Reliable information about mental health changes associated with the pandemic will help service providers make decisions that are underpinned by knowledge of the scale of changes in population mental health and recognize who is most vulnerable to symptoms of mental distress. This study aimed to investigate the psychological outcome of “COVID-19” in university students. Furthermore, an association of these outcomes with sociodemographic variables and knowledge factors were determined.



A cross-sectional study through an online survey was conducted at Umm-Al-Qura University between October 1st to December 1st, 2020. The questionnaires were distributed to the target sample of university students through social media platforms using snowball-sampling technique. Platforms including Facebook, WhatsApp, and Twitter, as well as personal e-mail, were used for the recruitment and dissemination. The participants of this survey were mainly young people aged 18–25 years.

We calculated the sample size based on the assumption prevalence of 24% psychological impact according to Alkhamees et al. [10] at 5% absolute precision, power at 80% and a confidence interval of 95%. Taking into consideration a 20% non-response rate, the minimal sample size required was 345 participants. However, we intended to send the study questionnaires to 400 potential participants.

The inclusion criteria were current university students in Saudi Arabia who spoke and understood English and had access to the online questionnaire.


Data collection sheet

A semi-structured study questionnaire was developed by researchers to obtain general information of the participants as such as gender, age, education, marital status, occupation, income. The Latter half of the questionnaire included questions related to general and mental health, “COVID 19” exposure and, knowledge regarding “COVID-19”. Knowledge questions included ten items inquiring about knowledge regarding mode of spread, ways of prevention and, symptoms. The participants could select “yes or no” options. A pilot study was done on 50 participants to check the validity and reality of the scale.

Depression Anxiety Stress Scale-21

Psychological outcomes were assessed using Depression Anxiety Stress Scales (DASS-21) The DASS-21 is a screening tool used for the general population for screening depression, anxiety and, stress. It is a self-administered 21-item instrument, which screens for depression, anxiety and, stress based on the recommended severity thresholds for the depression, anxiety, stress subscales [21]. Each subscale is composed of seven items, and each response was rated from 0 to 3. The depression subscales, scores of 0–9 was considered “normal” 10–12 “mild”, 13–20 “moderate”, 21–27 “severe”, and 28–42 as “extremely severe”. The anxiety sub-score was categorized into the following scores, “normal” (0–6) “mild” (7–9), “moderate” (10–14), “severe” (15–19), and extremely severe” (20–42). The stress subscale score was categorized into “normal” (0–10) “mild” (11–18), “moderate” (19–25), “severe” (26–33), and “extremely severe” stress [22]. Participants were asked to report the presence of a symptom over the past week. Scores for three emotional states were calculated by adding the points for the relevant items question for depression, stress, anxiety and doubling up the score [22].

Statistical analysis

All the data collected through google forms were converted to excel spreadsheets and analysis was performed using IBM SPSS Statistics for Windows, version 22.0 (IBM Corp., Armonk, NY, USA). The data were cleaned, sorted, and processed before the commencement of analyses. The survey’s answers fields were designed to be mandatory to be filled before proceeding to the next section, options such as “None” or “I don’t know” were provided wherever necessary to minimize missed data. Kolmogorov–Smirnov (K–S) test was used to check normality of the data distribution.

Descriptive analyses were performed for sample characteristics, history of “COVID-19” in self or family, history of contact with “COVID-19” positive patient, knowledge towards various aspects of “COVID-19” and concerns, and precautionary measures. The results of these analyses were presented as frequencies and percentages for categorical variables and as means and standard deviations for continuous variables.

The psychological burden of the “COVID-19” pandemic was measured using scores on the three subscales of the DASS; the scores were presented as means with standard deviations. Bivariate analyses were performed to find the relationship between the individual variables and scores on each of the three scales (DASS-stress, DASS anxiety, and DASS-depression) using independent t-test to compare two groups. All tests of associations were carried out at a significance level of < 0.05.


Participant’s characteristics

Out of the 400 students who were invited to participate in the survey through the online link, 369 agreed to participate and completed the study questionnaire giving a response rate of 92.2%. Among the participants 269 (72.8%) belonged to department of laboratory medicine and 100 (27.1%) to department of medicine. The demographic information for the 369 participants (323 [87.5%] females and 46 [12.5%] males) is shown in Table 1. Their ages ranged from 18 to 30 years but most of the participants were between 18 and 25 years (91.3%). Besides, 91.8% of the participant were undergraduate students and 8.2% were post-graduate students. Most of the participants were unmarried (91.3%). History of psychiatric illness was found in 14.6% and 18.7% reported a positive family history of psychiatric illness. The “COVID 19” exposure information revealed 16% got infected with the virus, 40.1% reported family members getting infected, 30.9% reported, quarantine due to contact with the positive patient and, 15.7% reported hospitalization with 24.4% landing up in the intensive care unit (ICU) (Table 1).

Table 1 Socio-demographic characteristics of the study participants (N = 369)

Knowledge regarding “COVID-19” among students

Regarding the knowledge on various aspects of “COVID-19”, the majority (94.6%) of the participants knew correctly that “COVID-19” can be prevented by the use of face mask, social distancing, and handwashing and 94.0% knew its mode of transmission, whereas only 39.6% of the participants knew that 56 °C for 30 min, diethyl ether, 75% ethanol, peracetic acid and, other lipid solvents can effectively kill the virus causing “COVID-19”. The Majority of the participants exhibited good knowledge about general symptoms related to “COVID-19” illness (91.6%) including the knowledge about breathlessness and low oxygen saturation (85.9%), whereas 74.3% of the participants knew about gastrointestinal symptoms as the presentation of “COVID-19”. Awareness about psychological balance and its relation with improved immunity was found in 77.8% (Table 2).

Table 2 Responses to knowledge and practices questions on COVID-19 by the study participant (N = 369)

Psychological impact

Using the specified cut-offs of the DASS-21 scoring system to screen for depression, anxiety and, stress. We found depressive symptoms in 190 (51.4%), anxiety symptoms in 214 (57.9%) and, stress in 179 (48.5%) study participants. The overall mean DASS-21 depression subscale score was 11.25 ± 10.86. Among the 190 students who screened positive for depressive symptoms, 22.6% scored mild, 38.4% moderate, 15.8% severe and, 23.2% extremely severe on the DASS sub-score for depressive symptoms. The overall mean DASS-21 anxiety symptoms subscale score was 10.16 ± 9.62. Of the 214 patients who screened positive for anxiety, 13.6% of them showed mild anxiety, 38.8% moderate, 11.2% severe and, 36.4% extremely severe anxiety symptoms. In terms of the DASS-21 stress subscale, the overall mean score was 11.55 ± 10.36. Stress was mild in 49.7%, moderate in 27.9%, severe in 16.2% and, extremely severe in 6.2% participants screened positive for stress (n = 179) (Table 3).

Table 3 Prevalence and severity of depression, anxiety and stress among the study participants as per DASS-21 scores (N = 369)

Sample characteristics and psychological impact

There was no significant statistical association found between the DASS-21 score and sociodemographic factors like age, sex, marital status and, educational levels. The history of psychiatric illness in the participants showed higher scores on depressive symptoms (p = 0.001), anxiety symptoms (p = 0.01) and, stress (p = 0.04) symptoms. Positive family history of psychiatric illness was significantly related with a high score on depressive symptoms (p = 0.03), anxiety (p = 0.005) and, stress (p = 0.02) symptoms. While the history of chronic medical illness has shown high scores of stress symptoms (p = 0.01). History of contracting “COVID-19” was related with high scores on anxiety (p = 0.004) and depressive symptoms (p = 0.02) subscale while the factors such as family member getting infected with “COVID-19”, history of quarantine and close contact with “COVID”-positive case had not shown any significant change in DASS-21 scores. Participants hospitalized with “COVID-19” has shown a significantly high anxiety symptom (p = 0.0003). Participants admitted to ICU reported significantly high anxiety scores (p = 0.0003) and stress scores (p = 0.04) (Table 4).

Table 4 Association of DASS-Depression, Anxiety and Stress Scores with sociodemographic characteristics and COVID-19 contracting history of the participants (N = 369)

Knowledge variables and psychological impact

Most of the knowledge variables were not associated with significantly increased scores on DASS-21. The knowledge about the agents that can effectively kill the virus causing “COVID-19” showed significantly high scores on the depression subscale (p = 0.01) and respiratory droplet as a mode of transmission was associated with higher scores on the anxiety subscale (p = 0.007). Knowledge regarding the surface contamination as a mode of spread was associated with a significantly high score of stress (p = 0.004) and anxiety (p = 0.002). Knowing that “COVID-19” can also clinically present with gastrointestinal symptoms showed significantly high scores on stress (p = 0.005) and anxiety (p = 0.01) subscale than any other way of clinical presentation (Table 5).

Table 5 Association of knowledge of COVID-19 with DASS stress, anxiety and depression scores of the participants (N = 369)


Previous studies in Saudi Arabia have shown a high prevalence of anxiety and depression in medical students [23], and college students [24] irrespective of any emergency or epidemic. Studies worldwide have shown an increased psychological impact on college and university students during the “COVID-19” pandemic [14,15,16,17]. Overall, we found higher stress, anxiety, and depressive symptoms in the study participants when compared to previous studies in the region of Saudi Arabia [25, 26]. Contrary to this, few studies found higher level of stress than our study participants [27, 28]. The higher prevalence in our sample could be because of the fact that our sample consisted of purely university students and female participants which is in line with previous studies reporting a higher prevalence of anxiety and depression in female gender and university students [8,9,10]. Moreover, we found significant number of subjects with positive past and, family history of psychiatric illness respectively, which could be another reason for higher prevalence as compared to previous studies. Nonetheless, factors like coping styles, social support [29], personality [30] and religiosity [31] could be among other factors affecting the psychological heath of students. Interestingly, depression, anxiety, and stress have not only been highly prevalent during the “COVID-19” pandemic, but also after the movement lockdown was lifted [32]. Our study indicates that university students are having a considerable amount of mental health burden. However, these findings may be confounded by the time and type of examination in different years, different studying materials and different studying years. The ambiguity about the future and detrimental effect on academic progression could be the cause for mental health issues among students.

Participants getting infected with SARS-CoV-2 irrespective of admission showed significantly high levels of depression and anxiety while those admitted to hospital and ICU reported significantly high levels of anxiety and stress. This finding is similar to studies reporting a high level of anxiety, depression and, PTSD in patients diagnosed with “COVID-19” [33]. Nonetheless, coronavirus infections are also known as neurotropic viruses due to their affinity to the nervous system [34]. SARS-CoV-2 neuro-invasion was demonstrated in human cell cultures and post-mortem studies [35]. Thus, the neuroinflammation caused by SARS-CoV-2 may cause neuropsychiatric illness [36].

It was found that most of the participants had good knowledge (90–95%) about “COVID-19” for most of the knowledge variables when compared to a Chinese study (50–60%) [37]. The knowledge regarding the ability of solvents like diethyl ether, 75% ethanol, peracetic acid, other lipid solvents and, 56 °C heat effectively killing the virus causing “COVID-19” was found in 39.6%, which is comparable to the finding of a Chinese study reporting 30% participants knowing the same factor [37]. Our study found that 77.8% of the participants knew that psychological balance improves immunity, whereas a similar study from China revealed only 37% of participants knew about this fact [37]. Our findings suggest that knowledge regarding the incubation period, preventive measures, early signs of “COVID-19” and, the effect of psychological balance on immunity was not s depression, anxiety and, stress symptoms. Similarly, previous studies have suggested that overall knowledge about “COVID 19” had a protective psychological effect [38,39,40]. A previous study reported a higher level of anxiety and depression in individuals having good knowledge about handwashing as a preventive measure for “COVID-19” [32], whereas our study reported high levels of anxiety and stress in individuals knowing about surface contamination and respiratory droplet as a mode of spread. Research and clinical observations suggested that during pandemics increased anxiety and stress in association with fear of coming in contact with infected objects or surfaces [40]. However, descriptive findings of this study indicate that university students possessed an adequate level of knowledge related to “COVID-19” at the time of the survey administration. Additionally, our sample included students from medical and paramedical courses hence, more likely to be attuned to correct information related to “COVID-19”.

Adequate pandemic-related knowledge, teaching psychological strategies (e.g., training of resilience factors and coping strategies) and social support help reduce negative psychological affect [41,42,43]. Besides, biofeedback, mindfulness techniques (e.g., meditation) [42] and cognitive behavioral therapy [44] are useful measures to combat psychological affect of “COVID-19”. Online psychological counselling services by mental health professionals in medical institutions, universities, and academic societies and online psychological self-help intervention systems, including online cognitive behavioral therapy for depression, anxiety, and insomnia have shown to be effective in combating the mental health issues [45].


Our study had few limitations worth mentioning. Since the study design is cross-sectional, the causal association cannot be established. Thus, findings need to be supported by well-designed longitudinal studies. Further studies about the impact of COVID-19 with follow-up these students may help shed some light on the psychological effect among students. Since the data collection was online, the reliability and accuracy of information provided may be limited. Furthermore, the recruitment of subjects via social media could also induce a selection bias of those students that experience more than average mental health issues. There is a possibility of self-rating bias and issues of subjectivity and reliability since the measure used to assess psychological impact was a self-rating scale. The higher scores were not further evaluated by a psychiatrist to confirm the presence of a psychiatric disorder. Moreover, the questionnaire and scale were not translated in Arabic.


Our study findings reflect the increased mental health burden among the university students due to the “COVID-19” pandemic. The Government should consider incorporating mental health and psychological intervention within the “COVID-19” outbreak prevention and mitigation program for vulnerable groups such as health care professionals and students. To alleviate the mental health burden of the “COVID-19” pandemic, mental health interventions and professionally trained counsellors shall be made available within the campus. Future research should be aimed at targeting multiple universities for longer periods to identify the full spectrum and course of student mental disorders. Longitudinal studies in the future may help answer whether direct or indirect exposure to the “COVID-19” virus added to mental health disorders. Continuation of face-to-face academic activities and social interaction may be of paramount importance to protect the psychological wellbeing of university students.

Availability of data and materials

Not applicable.



Coronavirus disease 2019


World Health Organization


Post-traumatic stress-disorder


Depression Anxiety Stress Scale-21


  1. Saudi Ministry of Health; 2020. Available from: Accessed 1 Dec 2020 [Ref list].

  2. Wang C, Pan R, Wan X, Tan Y, Xu L, Ho CS, Ho RC. Immediate psychological responses and associated factors during the initial stage of the 2019 coronavirus disease (COVID-19) epidemic among the general population in China. Int J Environ Res Public Health. 2020;17:1729.

    Article  CAS  Google Scholar 

  3. Li J, Yang Z, Qiu H. Anxiety and depression among general population in China at the peak of the COVID-19 epidemic. World Psychiatry. 2020;19:249–50.

    Article  Google Scholar 

  4. Lei L, Huang X, Zhang S, Yang J, Yang L, Xu M. Comparison of prevalence and associated factors of anxiety and depression among people affected by versus people unaffected by quarantine during the COVID-19 epidemic in Southwestern China. Med Sci Monit. 2020.

    Article  Google Scholar 

  5. Qiu J, Shen B, Zhao M, Wang Z, Xie B, Xu Y. A nationwide survey of psychological distress among Chinese people in the COVID-19 epidemic: implications and policy recommendations. Gen Psychiatry. 2020;33(2):e100213.

    Article  CAS  Google Scholar 

  6. González-Sanguino C, Ausín B, Castellanos MA. Mental health consequences during the initial stage of the 2020 coronavirus pandemic (COVID-19) in Spain. Brain Behav Immun. 2020;87:172–6.

    Article  Google Scholar 

  7. Osman DM, Khalaf FR, Ahmed GK, et al. Worry from contracting COVID-19 infection and its stigma among Egyptian health care providers. J Egypt Public Health Assoc. 2022;97:2.

    Article  Google Scholar 

  8. Al-Hanawi MK, Mwale ML, Alshareef N, Qattan AMN, Angawi K, Almubark R, et al. Psychological distress amongst health workers and the general public during the COVID-19 pandemic in Saudi Arabia. Risk Manag Healthc Policy. 2020;13:733–42.

    Article  Google Scholar 

  9. Alyami HS, Naser AY, Dahmash EZ, Alyami MH, Alyami MS. Depression and anxiety during the COVID-19 pandemic in Saudi Arabia: A cross-sectional study. Int J Clin Pract. 2021;75(7):e14244.

  10. Alkhamees AA, Alrashed SA, Alzunaydi AA, Almohimeed AS, Aljohani MS. The psychological impact of COVID-19 pandemic on the general population of Saudi Arabia. Compr Psychiatry. 2020;102: 152192.

    Article  Google Scholar 

  11. Zimmermann M, Bledsoe C, Papa A. Initial impact of the COVID-19 pandemic on college student mental health: a longitudinal examination of risk and protective factors. Psychiatry Res. 2021;305: 114254.

    Article  CAS  Google Scholar 

  12. Rose S. Medical student education in the time of COVID-19. JAMA. 2020;323(21):2131.

    Article  CAS  Google Scholar 

  13. Heinen I, Bullinger M, Kocalevent RD. Perceived stress in first year medical students—associations with personal resources and emotional distress. BMC Med Educ. 2017;17:4.

    Article  Google Scholar 

  14. Cao W, Fang Z, Hou G, Han M, Xu X, Dong J, Zheng J. The psychological impact of the COVID-19 epidemic on college students in China. Psychiatry Res. 2020;287:112934.

    Article  CAS  Google Scholar 

  15. Wang ZH, Yang HL, Yang YQ, Liu D, Li ZH, Zhang XR, et al. Prevalence of anxiety and depression symptom, and the demand for psychological knowledge and interventions in college students during COVID-19 epidemic: a large cross-sectional study. J Affect Disord. 2020;275:188–93.

    Article  CAS  Google Scholar 

  16. Tanga W, Hu T, Hu B, Jin C, Wang G, Xie C, et al. Prevalence and correlates of PTSD and depressive symptoms one month after the outbreak of the COVID-19 epidemic in a sample of home quarantined Chinese university students. J Affect Disord. 2020;274:1–7.

    Article  Google Scholar 

  17. Abdulghani HM, Sattar K, Ahmed T, Akram A. Association of COVID-19 pandemic with undergraduate medical students’ perceived stress and coping. Psychol Res Behav Manag. 2020;13:871–88122.

    Article  Google Scholar 

  18. Voltmer E, Kötter T, Spahn C. Perceived medical school stress and the development of behavior and experience patterns in German medical students. Med Teach. 2012;34(10):840–7.

    Article  CAS  Google Scholar 

  19. Husky MM, Kovess-Masfety V, Swendsen JD. Stress and anxiety among university students in France during Covid-19 mandatory confinement. Compr Psychiatry. 2020;102: 152191.

    Article  Google Scholar 

  20. Galic M, Mustapic L, Šimunic A, Sic L, Cipolletta S. COVID-19 related knowledge and mental health: case of Croatia. Front Psychol. 2020;11:567368.

    Article  Google Scholar 

  21. Lovibond SH, Lovibond PF. Manual for the Depression Anxiety Stress Scales. 2nd ed. Sydney: Psychology Foundation of Australia; 1995.

    Google Scholar 

  22. Antony MM, Cox BJ, Enns MW, Bieling PJ, Swinson RP. Psychometric properties of the 42-item and 21-item versions of the depression anxiety stress scales in clinical groups and a community sample. Psychol Assess. 1998;10:176–81.

    Article  Google Scholar 

  23. Inam B. Anxiety and depression among students of a medical college in Saudi Arabia. Int J Health Sci. 2007;1:295–300.

    Google Scholar 

  24. Amr M, Amin TT, Saddichha S, Al Malki S, Al Samail M, Al Qahtani N, et al. Depression and anxiety among Saudi University students: prevalence and correlates. Arab J Psychiatry. 2013;24:1–7.

    Article  Google Scholar 

  25. Khoshaim HB, Al-Sukayt A, Chinna K, Nurunnabi M, Sundarasen S, Kamaludin K, Baloch GM, Hossain SFA. Anxiety level of university students during COVID-19 in Saudi Arabia. Front Psychiatry. 2020;11: 579750.

    Article  Google Scholar 

  26. Al-Hazmi AM, Sheerah HA, Arafa A. Perspectives on telemedicine during the era of COVID-19; What can Saudi Arabia do? Int J Environ Res Public Health. 2021;18(20):10617.

    Article  CAS  Google Scholar 

  27. AlAteeq DA, Aljhani S, AlEEsa D. Perceived stress among students in virtual classrooms during COVID-19 outbreak in KSA. J Taibah Univ Med Sci. 2020;15(5):398–403.

    Google Scholar 

  28. Badr AF, Binmahfouz LS. Impact of COVID-19 pandemic on mental health among pharmacy students at King Abdulaziz University, Jeddah, Saudi Arabia. Mediterr J Soc Sci. 2020.

    Article  Google Scholar 

  29. Akbar Z, Aisyawati MS. Coping strategy, social support, and psychological distress among university students in Jakarta, Indonesia during the COVID-19 pandemic. Front Psychol. 2021;12: 694122.

    Article  Google Scholar 

  30. Liua S, Lithopoulosa A, Zhanga CQ, Garcia-Barrerad MA, Rhodesa RE. Personality and perceived stress during COVID-19 pandemic: testing the mediating role of perceived threat and efficacy. Pers Individ Differ. 2021;168:110351.

    Article  Google Scholar 

  31. Lucchetti G, Garcia Góes L, Amaral SG, Ganadjian GT, Andrade I, Almeida PO, Mendes do Carmo V, Gonzalez Manso ME. Spirituality, religiosity and the mental health consequences of social isolation during Covid-19 pandemic. Int J Soc Psychiatry. 2020.

    Article  Google Scholar 

  32. Woon LS-C, Leong Abdullah MFI, Sidi H, Mansor NS, Nik Jaafar NR. Depression, anxiety, and the COVID-19 pandemic: severity of symptoms and associated factors among university students after the end of the movement lockdown. PLoS ONE. 2021;16(5):e0252481.

    Article  CAS  Google Scholar 

  33. Guo Q, Zheng Y, Shi J, Wang J, Li G, Li C, et al. Immediate psychological distress in quarantined patients with COVID-19 and its association with peripheral inflammation: a mixed-method study. Brain Behav Immun. 2020;88:17–27.

    Article  CAS  Google Scholar 

  34. Reiss CS. Neurotropic viral infections. Cambridge: Cambridge University Press; 2008.

    Book  Google Scholar 

  35. Song E, Zhang C, Israelow B, Lu-Culligan A, Sprado A, Skriabine S, et al. Neuroinvasion of SARS-CoV-2 in human and mouse brain. J Exp Med. 2021;218(3): e20202135.

    Article  CAS  Google Scholar 

  36. Vuren EJV, Steyn SF, Brink CB, Moller M, Viljoen FP, Harvey BH. The neuropsychiatric manifestations of COVID-19: interactions with psychiatric illness and pharmacological treatment. Biomed Pharm. 2021;135:111200.

    Article  CAS  Google Scholar 

  37. Liang L, Ren H, Cao R, Hu Y, Qin Z, Li C, Mei S. The effect of COVID-19 on youth mental health. Psychiatr Q. 2020.

    Article  Google Scholar 

  38. Tee ML, Tee CA, Anlacan JP, Aligam KJG, Reyes PWC, Kuruchittham V, Ho RC. Psychological impact of COVID-19 pandemic in the Philippines. J Affect Disord. 2020;277:379–91.

    Article  CAS  Google Scholar 

  39. Kecojevic IA, Basch CH, Sullivan M, Davi NK. The impact of the COVID-19 epidemic on mental health of undergraduate students in New Jersey, cross-sectional study. PLoS ONE. 2020;15(9):e0239696.

    Article  CAS  Google Scholar 

  40. Taylor S. The psychology of pandemics: preparing for the next global outbreak of infectious disease. Newcastle upon Tyne: Cambridge Scholars Publishing; 2019.

    Google Scholar 

  41. Kunzler AM, Stoffers-Winterling J, Stoll M, Mancini AL, Lehmann S, Blessin M, et al. Mental health and psychosocial support strategies in highly contagious emerging disease outbreaks of substantial public concern: a systematic scoping review. PLoS ONE. 2021;16(2): e0244748.

    Article  CAS  Google Scholar 

  42. Hatta S. The psychological sequelae during mental health and Covid-19 pandemic: learning from the past for today’s coping styles. Med Health. 2020;15(1):1–4.

    Article  CAS  Google Scholar 

  43. Leppin AL, Bora PR, Tilburt JC, Gionfriddo MR, Zeballos-Palacios C, Dulohery MM, et al. The efficacy of resiliency training programs: a systematic review and meta-analysis of randomized trials. PLoS ONE. 2014;9(10): e111420.

    Article  CAS  Google Scholar 

  44. Cole CL, Waterman S, Hunter ECM, Bell V, Greenberg N, Rubin GJ, et al. Effectiveness of small group cognitive behavioural therapy for anxiety and depression in Ebola Treatment Centre staff in Sierra Leone. Int Rev Psychiatry. 2020;17:1–9.

    Article  Google Scholar 

  45. Liu S, Yang L, Zhang C, Xiang Y, Liu Z, Hu S, et al. Online mental health services in China during the COVID-19 outbreak. Lancet Psychiatry. 2020;7(4):E17–8.

    Article  Google Scholar 

Download references


This research would not have been possible without the exceptional support of our Head of the Department, Dr. Ahmed H. Qassem of Laboratory Medicine, Faculty of Applied medical sciences, Umm Al-Qura University.


Not applicable.

Author information

Authors and Affiliations



SS: conceptualization, methodology, validation, formal analysis, investigation, resources, data curation, writing—original draft, review & editing, supervision, project administration. MAB: methodology, validation, formal analysis, investigation, resources, data curation, review & editing, supervision, project administration. IN: validation, formal analysis, data curation & editing. AT: conceptualization, methodology, formal analysis, review & data collection. MSI: conceptualization, methodology, software, validation, data collection review & editing. IN: conceptualization, methodology, formal analysis, review & data collection. NMA: conceptualization, methodology, formal analysis, review & data collection. MT: conceptualization, methodology, formal analysis, review & data collection. GWM: conceptualization, methodology, formal analysis, review & data collection. RKM: conceptualization, methodology, formal analysis, review & data collection. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Sadia Sultan.

Ethics declarations

Ethics approval and consent to participate

Since it was a survey study ethical permission was not needed. However, Institutional review board permission was obtained, questionnaire included a consent to participate and anonymity of the participants was strictly maintained.

Consent for publication

Not applicable.

Competing interests

The author declares they have no competing interests.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sultan, S., Abu Bashar, M., Tabassum, A. et al. Prevalence of depression, anxiety, stress and its relationship with knowledge about COVID-19 in medical and laboratory medicine students of Umm-Al-Qura University: a cross-sectional survey. Egypt J Neurol Psychiatry Neurosurg 58, 160 (2022).

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: