Articles

An insight into Alzheimer’s disease and its on-setting novel genes

According to the World Health Organisation, as of 2019, globally around 50 million people suffer from dementia, with approximately another 10 million getting added to the list every year, wherein Alzheimer’s d...

Authors: Jaanaky Vigneswaran, Sivaloganathan Anogh Muthukumar, Mohamed Shafras and Geetika Pant

Prognostic value of glucose fluctuation in patients undergoing thrombolysis or thrombectomy due to acute ischemic stroke

Hyperglycemia during acute ischemic stroke is associated with worse outcomes, and this glucose altitude may persist in the initial days. In this study, we investigate the effect of glucose fluctuations in the ...

Authors: Sibel Ciplak, Ahmet Adiguzel, Unal Ozturk and Yahya Akalin

Clinical and morphological features of SARS-COV-2 associated acute hemorrhagic necrotizing encephalopathy: case report

The current case report presents acute hemorrhagic necrotizing encephalopathy (AHNE) as an example of a fatal complication, the etiology of which could be coronavirus disease 2019 (COVID-19) with multiple orga...

Authors: Victor Vladimirovich Ermilov and Nikita Alexeevich Dorofeev

Rasmussen syndrome in a tropical environment: a study of six (6) observations

In sub-Saharan Africa, encephalitis of various etiologies is a major public health problem and Rasmussen syndrome is rarely diagnosed due to under-medicalization. The objective of this study is to describe the...

Authors: Carlos Othon Guelngar, Touré Mohamed Lamine, Barry Mamadou Ciré, Diakité Mamady, Konaté Mahadi, Djibo Hamani Bachir Abdoul, Sakadi Foksouna, Djibo Hassane Fatimata, Camara Naby, Kassa Dago François, Bah Fatimatou Korka, Camara Doussou, Millimono Victorine, Condé Salematou, Sakho Aminata, Diallo Mohamed Tafsir…

Isolated traumatic acute subdural haematoma: outcome in relation to age, Glasgow Coma Scale, and haematoma thickness

Traumatic acute subdural haematoma occurs in about 10–20% of patients with severe head injuries. This study aims to investigate the relation between outcome and the age, Glasgow Coma Scale on admission as well...

Authors: Mohamed A. Ragaee, Radwan Nouby Mahmoud, Mohamed Ahmed Alghriany and Wael M. A. Abd El-Ghani

Area postrema syndrome in neuromyelitis optica spectrum disorder: diagnostic challenges and descriptive patterns

Although area postrema syndrome (APS) is one of the core clinical features of neuromyelitis optic spectrum disorder (NMOSD), it is frequently misdiagnosed as gastrointestinal or systemic disorders. In this stu...

Authors: Eman M. Khedr, Hassan M. Farweez, Noha Abo Elfetoh, Eman R. Badawy, Sara Hassanein, Doaa M. Mahmoud and Ahmed Nasreldein

Role of neuro-sonography of peripheral nerves as a diagnostic and a differentiation tool of amyotrophic lateral sclerosis

Motor neuron disease is a heterogeneous group of progressive neurodegenerative disorders, most common of which is amyotrophic lateral sclerosis (ALS). There are many clinical and radiological criteria to diagn...

Authors: Rana Zakaria Ahmed Mohamed, Haitham Hamdy Salem, Hossam Moussa El-Sayed Sakr, Hossam-Eldin Mahmoud Afifi, Ahmed Mohammed Elsadek and Nagia Aly Fahmy

Gut microbiota in Parkinson’s disease patients: hospital-based study

Parkinson’s disease (PD) is one of the most common neurodegenerative diseases. There is accumulating evidence that link gut microbiota to symptomatology and pathophysiology of PD. The aim of this study was to ...

Authors: Eman M. Khedr, Anwar M. Ali, Enas Deaf, Hebatallah M. Hassan, Ahmed Alaa and Ayman Gamea

Migraine in patients with rheumatoid arthritis and its relation to disease activity

The comorbidity between rheumatoid arthritis (RA) and migraine is complex and not completely understood.

Authors: Hassan Abd-Elaty El-Sonbaty, Carmen Ali Zarad, Mohamed Rezk Mohamed and Ali Ahmed Abou Elmaaty

NeuroAid II (MLC901) and polypharmacy in stroke and the risk of hepatotoxicity: a case report

NeuroAid II (MLC901) is a promising therapy for stroke patients who present outside of therapeutic window for reperfusion therapy. Studies have proven its efficacy in ischemic stroke; however, data of drug saf...

Authors: Anna Misya’il Abdul Rashid, Mohamad Syafeeq Faeez Md Noh, Abdul Hanif Khan Yusof Khan, Wei Chao Loh, Janudin Baharin, Azliza Ibrahim, Liyana Najwa Inche Mat, Wan Aliaa Wan Sulaiman, Fan Kee Hoo, Fazah Akhtar Hanapiah and Hamidon Basri

Obsessive–compulsive disorder post-COVID-19: a case presentation

Since the emergence of the COVID-19 pandemic and the significant changes that impacted because of it, people around the world have been left dealing with its consequences—fear of becoming ill and dying, fear o...

Authors: Abdulmajeed A. Alkhamees

Does the second ischemic stroke herald a higher proportional risk for cognitive and physical impairment than the first-ever one?

Post-stroke cognitive and physical disabilities are common sequelae; however, it seems that the second ischemic stroke carries a higher proportional risk more than expected. In this study, we aimed to study se...

Authors: Mohammed Ezzat Elwan, Aktham Ismail Al-emam, Ahmed Nabil Munir and Mostafa Saleh Melake

Risk factors and impact of stigma on psychiatric patients in Sohag

Stigma among psychiatric patients is pervasive all over the world. Our aim in this study was to investigate risk factors for stigma related to psychiatric disorders and to demonstrate the major consequences of...

Authors: Taher Abdelraheem Sayed, Magda Mohamed Ali and Saber Hadad

Time to diabetic neuropathy and its predictors among newly diagnosed type 2 diabetes mellitus patients in Northwest Ethiopia

Despite the high number of patients suffering from the negative impact of diabetic neuropathy (DN) in Ethiopia, evidence regarding the time to DN and its predictors are not well document in Ethiopia. Therefore...

Authors: Sewnet Adem Kebede, Biruk Shalmeno Tusa, Adisu Birhanu Weldesenbet, Zemenu Tadesse Tessema and Tadesse Awoke Ayele

The effect of bilateral tDCS over dorsolateral prefrontal cortex on the cognitive abilities of men with opioid use disorder under methadone therapy: A sham-controlled clinical trial

Opioid use disorder (OUD) can have negative impact on cognitive functions. This study aims to evaluate the effect of bilateral transcranial direct-current stimulation (tDCS) over the right/left dorsolateral pr...

Authors: Hossein Mostafavi, Mohsen Dadashi, Alireza Armani Kia, Davod Ahmadi, Reza Pirzeh and Zakaria Eskandari

Functional gait assessment in early and advanced Parkinson’s disease

Postural instability and balance problems in patients with Parkinson’s disease (PD) can seriously affect the quality of life and lead to falls with a subsequent increase in the morbidity and mortality. Early i...

Authors: Hany Mohamed Eldeeb and Heba Samir Abdelraheem

Neurophysiological biomarkers of peripheral nervous system affection in patients with stable chronic obstructive pulmonary disease (COPD)

Chronic obstructive pulmonary disease (COPD) is accompanied by substantial systemic dysregulations that comprise systemic inflammation and neurohormonal activation in addition to many neurological involvements...

Authors: Hossam Abd El Monem Ali and Ahmed Salama Al-Adl

Clinical features contributing to the sit-to-stand transfer in people with Parkinson’s disease: a systematic review

The aim of this systematic review is to present the existing literature on the clinical motor, and non-motor factors contributing to sit-to-stand transfer in individuals with Parkinson's disease.

Authors: Charmaine Pearl Da Cunha, Pratiksha Tilak Rao and Suruliraj Karthikbabu

Dispensing patterns of drugs used for neuropathic pain and adherence to NeuPSIG guideline: an observational study

Neuropathic pain is a common chronic ailment that can be challenging to treat because of the heterogeneity of its etiologies, symptoms, and underlying mechanisms. Drugs to treat neuropathic pain are highly pre...

Authors: Bahia Chahine and Farah Al Souheil

Relationship of Alberta Stroke Program Early CT Score (ASPECTS) with the outcome of ischemic stroke and the neurocognitive stroke biomarkers

Reliable and acceptable biomarkers are needed to anticipate the outcome and cognitive impairment following ischemic stroke. The goal of this research is to examine the association of ASPECTS with cognitive dec...

Authors: Ahmed Esmael, Mohammed Elsherief, Ahmed Abdel Khalek Abdel Razek, Nehal Tharwat Mohammed El-Sayed, Mohammed Abd Elsalam, Mohamed E. Flifel and Saad Shawki

Copeptin: a potential blood biomarker for acute ischemic stroke

Copeptin is a new blood biomarker for acute ischemic stroke which emerged to assist clinicians with decision-making. Serum copeptin can accurately reflect vasopressin concentration, which plays a role in aggra...

Authors: Mohammed I. Oraby, Rasha H. Soliman, Rehab M. Abd Elkareem and Amna I. Mohammed

Depression among health workers caring for patients with COVID-19 in Egypt

Health care workers caring for patients with COVID-19 pandemic are prone to extraordinary stressors and psychological problems. The aim of this study was to estimate the prevalence and risk factors of major de...

Authors: Hayam Mohamed Elgohary, Mohammad Gamal Sehlo, Medhat Mohamed Bassiony, Usama Mahmoud Youssef, Dina Sameh Elrafey and Shimaa Ibrahim Amin

Intracerebral hemorrhage due to moyamoya syndrome as a rare presentation of cerebral rheumatoid vasculitis: a case report

Central nervous system affection in rheumatoid arthritis is rare. The most frequently encountered neurological complications with rheumatoid arthritis are peripheral neuropathy and atlantoaxial subluxation wit...

Authors: Ayman Hassan El-Sudany, Salah Hussein El-Halawany, Shady S. Georgy, Amr S. Zaki, Rady Y. Bedros, Mostafa Hashim Mostafa and Ahmed El-Bassiouny

High-resolution neuromuscular ultrasound-based diagnosis of carpal tunnel syndrome in a sample of Egyptian population

Carpal tunnel syndrome is the commonest entrapment neuropathy. The cut-off point of cross-sectional area to diagnose carpal tunnel syndrome may vary among populations. The objective of this study was to determ...

Authors: Ahmed ElSadek, Mai Fathy and Amr AbdElMoneim

Surgical management of chronic subdural hematomas through single-burr hole craniostomy: is it sufficient?

Symptomatic chronic subdural hematomas (CSDH) remain one of the most encountered forms of intracranial hemorrhages particularly in the elder patients, yet fortunately implies a good surgical prognosis. Burr ho...

Authors: Omar El Farouk Ahmed, Ahmad El Sawy and Shafik El Molla

Psychomotor function in children with epilepsy seen at a tertiary hospital in southern Nigeria: does treatment with anti-epileptic drugs have any effect?

Psychomotor slowing is more commonly reported in children with epilepsy (CWE) compared to healthy controls. The effect of anti-epileptic drug (AED) treatment on psychomotor abilities of CWE remains controversi...

Authors: Paul Ehiabhi Ikhurionan, Olusola Peter Okunola, Blessing Imuetinyan Abhulimhen-Iyoha and Gabriel Egberue Ofovwe

Signs of neuroinflammation outweigh neurodegeneration as predictors for early conversion to MS

The pathophysiological mechanisms underlying multiple sclerosis include both inflammatory and degenerative processes. We aimed to study and compare markers of neuroinflammation and neurodegeneration in patient...

Authors: Nervana Mohamed El Fayomy, Hanan Helmy Mohamed, Manal Mohamed Kamal, Aya Hamid Alsayyad, Enas Hamid Alsayyad and Reham Mohamed Shamloul

How COVID-19 pandemic changed our management strategies for amyotrophic lateral sclerosis (ALS) patients: Egyptian study

There are several studies that have discussed the efficacy of telemedicine with amyotrophic lateral sclerosis (ALS) patients; however, this approach is still preliminary in Egypt and in North Africa. The objec...

Authors: Hebatallah R. Rashed

Evaluation of platelets activity and reactivity as risk factors for acute ischemic non-embolic stroke in young adults

Ischemic stroke (IS) constitutes a relevant health concern recently in younger population causing permanent cognitive and function-limiting disability and ranks as the 3rd cause of death in Egypt after cardiac...

Authors: Hebat-Allah Hassan Nashaat, Alaa El-Din Saad Abdelhamid, Amal Sayed Ahmed, Ahmed Osama Hosny, Mohamed A. Saad, Mohammed El Samahy and Amany Moustafa Hassan

Sinus venous thrombosis as a complication of COVID-19-associated hypercoagulability

Sinus venous thrombosis (SVT) is an increasingly recognised complication of not only SARS-CoV-2 infections, but also of SARS-CoV-2 vaccinations. SVT is attributed to hypercoagulability, a common complication o...

Authors: Sinda Zarrouk and Josef Finsterer

Enhanced sensory conduction in primary fibromyalgia: a case–control pilot study

This study aimed to test the changes in the conduction properties of peripheral nerves in patients with primary fibromyalgia (FM). Thirty patients with FM and sixteen healthy controls participated in this stud...

Authors: Mohamed N. Thabit, Mostafa Abdelmomen, Esam Aboelfadl and Saber Hadad

Outcomes of pregnancy in Egyptian women with multiple sclerosis in the new treatment era: a multi-center retrospective observational study

Pregnancy is a recent growing issue in multiple sclerosis (MS) and the update in the diagnostic criteria of MS and introduction of many disease-modifying therapies (DMTs) may cause changes in the relationship ...

Authors: Ali Mahmoud Ahmed, Mohamed Al-Bahay M. G. Reda and Ahmed Hassan Elsheshiny

Assessment of carpal tunnel syndrome via ultrasonography among hospital workers: a screening study

Carpal tunnel syndrome is a reasonably common disorder among working individuals. It may also be a cause of functional impairment. The aim of the study was to screen for the presence of carpal tunnel syndrome ...

Authors: Mai Fathy, Ahmed ElSadek, Eman Hamid and Amr AbdElMoneim

Frequency and risk factors of carotid artery disease among ischemic stroke patients in the south Egypt: hospital-based study

Limited data are available on the frequency of carotid artery disease among cerebrovascular ischemic stroke (CVS) patients in south Egypt. The aim of the present study is to determine the prevalence and risk f...

Authors: Eman Khedr, Abeer A. Tony, Mohamed Habeel and Ahmed Nasreldein

Assessment of cognitive functions in patients with multiple sclerosis

About 40–70% of patients with multiple sclerosis (MS) develop cognitive impairment (CI) throughout their life. We aim to study the influence of MS on cognitive changes. This is a case–control study of fifty pa...

Authors: Tara A. Al-Falaki, Farqad B. Hamdan and Nawfal M. Sheaheed

Epidemiological profile of brain tumors in Cameroon: a retrospective study

Brain tumors represent group of neoplasms originating from intracranial tissues and the meninges. The aim of this study was to determine the epidemiological profile of brain tumors seen in a referral health ce...

Authors: Mathieu Motah, Daniel Gams Massi, Fabien Fouda Bekolo, Nkemontoh Akweseh Nju, Aurélien Ndoumbe, Mireille Moumi, Anne Sango, Paul Shu and Victor Eyenga

High leukotriene B4 serum levels increase risk of painful diabetic neuropathy among type 2 diabetes mellitus patients

Painful diabetic neuropathy is one of the most common complications of type 2 diabetes mellitus, with approximately 30–50% of people will experience diabetic neuropathy. Chronic hyperglycemia will cause an inf...

Authors: Kelvin Yuwanda, I Putu Eka Widyadharma, Dewa Putu Gde Purwa Samatra, I Made Oka Adnyana, Anna Marita Gelgel and I Komang Arimbawa

Electrophysiological characteristics and anatomical differentiation of epileptic and non-epileptic myoclonus

Electrophysiological techniques have been used for discriminating myoclonus from other hyperkinetic movement disorders and for classifying the myoclonus subtype. This study was carried out on patients with dif...

Authors: Mohammad Abu-Hegazy, Azza Elmoungi, Eman Eltantawi and Ahmed Esmael

A study of anxiety, depression and stress symptoms among Fayoum medical students during COVID-19 lockdown, Egypt

The widespread pandemic of COVID-19 virus carries not only physical hazards, but also major psychological effects especially among medical students. The aim was to investigate the psychological effects of COVI...

Authors: Mohamed R. Soltan, Shaimaa S. Soliman and Mariam E. Dawoud

Neurological sequelae of COVID-19: a review

The COVID-19 pandemic has produced a myriad of challenges, including identifying and treating neurological sequelae.

Authors: Christopher J. Peterson, Ashish Sarangi and Fariha Bangash

Reply to Letter to Editor: Is SARS-CoV-2 responsible for relapses of Parkinson’s disease?

Authors: Walaa A. Kamel, Ismail Ibrahim Ismail, Mohamed Ibrahim and Jasem Y. Al-Hashel

Pathophysiology of SARS-CoV-2-associated ischemic stroke is variegated

Authors: Fulvio A. Scorza, Ana C. Fiorini and Josef Finsterer

Cognitive impairment and depression in patients with relapsing–remitting multiple sclerosis depending on age and neuroimaging findings

Multiple sclerosis is an insidious, disabling, both physically and mentally, demyelinating disease of the central nervous system. This work aims to evaluate relationships between cognitive impairment in separa...

Authors: Oksana O. Kopchak and Tetiana A. Odintsova

Dilemma of migraine diagnosis and management among non-neurologists

Migraine is a common and debilitating disorder however there is a wide gap in its diagnosis and management. Many migraine patients present to non-neurologists, so it is of utmost importance that non neurologis...

Authors: Mai Fathy, Ahmed ElSadek, Sherien Farag, Shahinaz Helmy and Amr AbdElMoneim

Impact of vitamin D level in diabetic people with peripheral neuropathy

Diabetes mellitus (DM) is a metabolic disease which is complicated by occurrence of diabetic peripheral neuropathy (DPN). Vitamin D deficiency contributes to the etiology and progression of type 2 DM and devel...

Authors: Mohammad H. Assy, Nashwa A. Draz, Sabah E. Fathy and Mohammad G. Hamed

A volumetric magnetic resonance imaging study in migraine

Although migraine phenotype has been widely described, the explanation of migraine pathophysiology still has a gap that might be partly bridged by neuroimaging investigations. The aim of the study is to assess...

Authors: Laila Elmously Naguib, Ghada Saed Abdel Azim and Mohammed Abdelrazek Abdellatif

Impact of body mass index on duplex parameters of cranial vessels among the Egyptian population

Obesity is a major health problem that affects different vascular systems, including cerebrovascular circulation. Carotid duplex is the best screening tool for early diagnosis of cerebrovascular changes in rel...

Authors: Tarek A. Rageh, Mostafa Ghazally and Khaled O. Mohamed

Serum levels of leptin and adiponectin in patients with multiple sclerosis

The role of adipokines such as leptin and adiponectin in regulating the immunity has been documented, however data concerning their consequence on multiple sclerosis (MS) Egyptian patients are deficient. The a...

Authors: Rasha M. Fahmi, Amr E. Kamel, Dorreya A. Elsayed, Amal A. Zidan and Noha T. Sarhan

Neurological manifestations of COVID-19 infection: an umbrella review

Neurological involvements of COVID-19 are one of the most reported manifestations of this infection. This study aims to systematically review the previous systematic reviews which addressed the neurological ma...

Authors: Samad Shams Vahdati, Alireza Ala, Dara Rahmanpour, Elyar Sadeghi-Hokmabadi and Fateme Tahmasbi

Giant intracavernous aneurysm presenting with isolated trigeminal neuralgia: a case report

Trigeminal neuralgia (TN) commonly affects individuals aged more than 50 years and is mostly primary owing to trigeminal nerve neurovascular compression. We report a case of secondary TN attributed to a giant ...

Authors: Fadhilah Hani Ishak, Abdul Hanif Khan Yusof Khan, Mohd Naim Mohd Yaakob, Mohd Fandi Al Khafiz Kamis, Anna Misyail Abdul Rashid, Wei Chao Loh, Janudin Baharin, Azliza Ibrahim, Liyana Najwa Inche Mat, Wan Aliaa Wan Sulaiman, Fan Kee Hoo and Hamidon Basri