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Prevalence and clinical implication of adverse childhood experiences and their association with substance use disorder among patients with schizophrenia
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery volume 58, Article number: 4 (2022)
Adverse childhood experiences (ACEs) and substance use disorder (SUD) are well-known risk factors for psychosis and dramatically affect schizophrenia. In this research, we aimed to measure the prevalence of adverse childhood experiences and substance use disorder in patients with schizophrenia and assess the effect of ACEs on the clinical presentation and overall functioning and the association between them and SUD in patients with schizophrenia. A cross-sectional study included a random sample of 165 schizophrenic patients who were examined by doing drug screen in urine, structured questionnaire to collect Socioeconomic characteristics, history of schizophrenia, structured clinical interview for Diagnostic and Statistical Manual of Mental Disorders-fifth edition, Positive and Negative Syndrome Scale (PANSS), Adverse Childhood Experiences International Questionnaire (ACE-IQ), World Health Organization Disability Assessment Schedule 2.0, compliance rating scale, addiction severity index fifth edition (ASI) for individuals with positive urine drug screen.
Only 14.4% of the studied patients had no adverse childhood experiences. The prevalence of positive substance abuse screening was 18.2%. There were statistically significant negative correlations between total ACE score and educational level, socioeconomic level, and the onset of schizophrenia. On the other hand, statistically significant positive correlations were found between the total ACE score and PANSS score and ASI score. The first most frequent ACE was significantly associated with female gender, lower education levels, low and middle socioeconomic classes, lifetime substance use, smokers, and positive drug screening. Emotional neglect and contact sexual abuse were significantly associated with positive drug screening. At the same time, Physical abuse was significantly associated with both lifetime substance use and positive drug screening.
The current study’s findings indicate that childhood adverse experiences and substance abuse are prevalent problems in patients with schizophrenia. Given that there is an association between both issues, they may affect the symptomatology of the disorder, the prognosis, and the therapeutic plan. It is advised that a greater emphasis on and identification of childhood trauma and drug use disorder may be a necessary step in assessing patients with schizophrenia.
Schizophrenia is a serious and persistent mental illness that affects around 20 million individuals worldwide. It is characterized by cognitive, perceptual, emotional, linguistic, and behavioral abnormalities. Hallucinations and delusions are frequently occurred. Its prevalence approaches 1% internationally. The incidence is about 1.5 per 10,000 people. Although schizophrenia can strike at any age, the typical age of onset for men is in their late teens to early twenties, and for women it is in their late twenties to early thirties. Schizophrenia is infrequent in children under the age of 12 or adults beyond the age of 40. Schizophrenia relates to significant impairment globally and can impair educational and occupational functioning. There is not a single element that has been established to cause schizophrenia via research. It is believed that schizophrenia is caused by an interplay between genes and a variety of environmental variables. Psychosocial variables may potentially play a role in the development of schizophrenia .
Over 69% of patients with schizophrenia do not receive adequate care, 90% of untreated schizophrenia patients live in low- and middle-income nations. Access to mental health care is a critical problem. Additionally, patients with schizophrenia seek care at a lower rate than the general population. Schizophrenia is a disorder that may be treated but requires lifelong treatment, even when symptoms have subsided. Medications are the cornerstone of schizophrenia treatment, and antipsychotic medications are the most prescribed drugs. Which include Second-generation antipsychotics, First-generation antipsychotics, and Long-acting injectable antipsychotics. The treatment modalities involve also Psychosocial interventions like Individual therapy, social skills training, Family therapy and Vocational rehabilitation and supported employment. Sometimes the patients need Hospitalization and Electroconvulsive therapy .
Schizophrenic patients are 2–3 times more likely than the general population to die prematurely. This is frequently the result of avoidable physical illnesses such as cardiovascular disease, metabolic disorders, and infection. People with schizophrenia frequently face stigma, discrimination, and violations of their human rights. Nearly 5% of schizophrenic people have a suicidal risk over their lifetime. Additionally, individuals with mental illnesses face a significantly elevated risk of accidental death, which is more likely than suicide .
A family history of schizophrenia, an older father, and autoimmune system abnormalities are among the risk factors for schizophrenia. Substance use disorders are a well-known risk factor for psychosis. According to the Epidemiologic Catchment Area study, 47% of schizophrenia patients had significant drug or alcohol use problems over their lifetime compared to 16% of the general population. People with schizophrenia are more likely to have alcohol and cannabis use problems, with lifetime prevalence ranging from 21 to 86% for alcohol and 17 to 83% for cannabis .
The risk of developing psychosis has long been linked to early childhood adverse experiences, characterized as physical or sexual violence, negligence, emotional abuse, injury, or fear of liability before 18 . This correlation was discovered to be a dose–response interaction. For instance, exposure to more than four adverse experiences during childhood has been linked to a tenfold increased risk of developing schizophrenia .
Adverse childhood experiences (ACEs) may affect the brain, immune, and endocrine systems as they mature. Children who are used to a high degree of environmental stress are more likely to adopt risky behaviors like smoking, consuming alcohol, or engaging in antisocial behavior. This sets the individual on the road to poor adult health, putting them at risk for various diseases such as cancer, cardiovascular disease, hepatic disease, and pulmonary disease .
Indeed, emotional and physical maltreatment in childhood and sexual assault has been linked to an elevated risk of cigarette smoking, alcohol consumption, intake of an illegal substance, and polydrug abuse .
Furthermore, adolescent females who have experienced sexual abuse as children are about five times more expected to be heavily involved in polysubstance misuse than teenage girls who have not experienced sexual abuse as children .
While existing research has found that Adverse childhood experiences (ACEs) affect later-life health outcomes and these may be a risk factor for multiple psychiatric disorders like substance use disorder (SUD) and schizophrenia, little research has been done on this topic in Egypt on such a vulnerable group of patients with schizophrenia. This gap in the research is alarming given the effects of adverse childhood experiences have been shown in developing countries . This is a crucial topic ripe for further investigation. As the youth represent more than one-third of the Egyptian people, it emphasizes the importance of safe families and adequate child-rearing environments.
In this research, we aimed to measure the prevalence of Adverse Childhood Experiences and substance use disorder and detect the association between them in patients with schizophrenia and their effect on the clinical presentation and overall functioning in those patients.
A cross-sectional study was performed from March to July 2019 on patients with schizophrenia at the psychiatric ward and the outpatient clinic of The University Hospital.
This study enrolled a random sample of 165 patients with schizophrenia after obtaining written informed consent from all of them.
Patients had to meet the following inclusion criteria to fulfill Diagnostic and Statistical Manual of Mental Disorders-fifth edition (DSM-5) criteria for schizophrenia, be 18 years or older, both genders, and all socioeconomic classes. Exclusion criteria included the following: patients with (acute psychotic episodes, comorbid psychiatric disorder other than SUD), and rejection to sign the consent.
The sample size was measured by assuming that the total number of patients with schizophrenia attending the psychiatric department of The University Hospital in 12 months is 288 patients. The prevalence of substance use disorder in schizophrenic patients is 50%. At a confidence level of 95%, the sample size in 165 patients. It was calculated by Open Epi .
Interviews were conducted, Face-to-face to collect data by the researchers. Patients from the psychiatric ward were interviewed upon discharge when their symptoms become stabilized (those patients did not have electroconvulsive therapy (ECT) during their admission in the psychiatric ward), while patients from the outpatient clinic were interviewed at their follow-up visits.
A structured questionnaire was used. It included the Socioeconomic characteristics measured by the scale for assessing family socioeconomic status (SES) for medical studies in Egypt . It is a previously validated, structured scale with an internal consistency of 0.66 (Cronbach’s alpha coefficient). Also, it included the history of the schizophrenic disorder, which involved the age of onset, duration of illness, family history, number of hospitalizations, medical history, consanguinity, tobacco smoking, and lifetime and current substance use (types of drugs, age of first drug abuse, duration of drug abuse, Abstinence, and hospitalization due to drug addiction).
The Structured Clinical Interview for SCID-5 -RV (Research Version) was applied to confirm the diagnosis of schizophrenia and substance use disorder. The SCID-5-RV for DSM-5 was released in 2016 and includes the DSM5 primary diagnoses, also involves more disorders with all associated subtypes, severity, and course specifiers than the clinician version. It’s used when the range of diagnoses covered in the Structured Clinical Interview for SCID-5 clinician version (SCID-5-CV) is insufficient (for example the assessment of certain disorders of interest are required but omitted from the SCID-5-CV, such as eating disorders), Also If the study requirements include making modifications such as, altering diagnostic time frames which we needed in our research. SCID 5 contains another two versions for personality disorders .
Positive and Negative Syndrome Scale (PANSS) was used to measure the symptoms’ severity. The PANSS is a standard psychiatric interview that assesses the occurrence and severity of positive and negative manifestations and general psychopathology of individuals who have recently been diagnosed with schizophrenia. It includes 30 items, Seven items for positive symptoms, seven for negative symptoms, and sixteen for general psychopathology symptoms. The severity of each item is determined by which anchoring points on a seven-point scale (1 = absent; 7 = extreme) better characterize the symptom’s presentation. In each of the subscales, elevated scores indicate more severity .
Adverse Childhood Experiences International Questionnaire (ACE-IQ) (Arabic version) was used . It was created by research teams from the (WHO), the Centers for Disease Control and Prevention, and international expertise. It was translated into Arabic and then back into English, with the vocabulary changed to be culturally adaptable. Additionally, it was pilot tested in the Kingdom of Saudi Arabia previously. The ACE-IQ questions address physical, sexual, and emotional assault and negligence by parents or caregivers; peer aggression; family discord (violence against household members; living with drug addicts, mentally disturbed, suicidal, or jailed household individuals, having one or no parents, divorce of the parents); and experiencing societal aggression and susceptibility to collective violence. For the current study, we did not involve the questions related to experiencing societal aggression and exposure to communal violence as these issues are not prevalent in Egypt. The questions regarding ACEs were binary and assessed the individuals’ first 18 years of life. The number of ACEs mentioned by respondents was calculated to produce the total ACE score (range 0–12).
Compliance Rating Scale (CRS) . On a seven-point scale, the CRS is used to rate drug adherence. Patients who reject treatment entirely receive a one-star rating, while those who partly refuse a two-star rating. Patients who reluctantly or passively accept treatment receive a three-, four-, or five-star rating, while those who reasonably or actively consider treatment receive a six- or seven-rating. The questionnaire includes a summary of compliance behavior for each score.
World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) was used . It includes twelve items. Impairment and disability were measured across 6 preceding months: cognition, mobility, self-care, social interaction, and interest in life and community practices. The items are graded on a five-point Likert scale, with 1 representing the absence of disability and 5 representing significant disability or incapacity to conduct a particular task. A cumulative disability score is calculated by combining the scores, with higher scores indicating more severe disability. The WHODAS were validated in Schizophrenia patients. An internal consistency of 0.78 (Cronbach’s alpha coefficient) .
Addiction Severity Index (ASI) fifth edition (Arabic version) was used for individuals with positive urine drug screen . It is a multidimensional interview that assesses the substance use, general condition, and social difficulties in individuals who have alcohol or other addiction issues, both during treatment and subsequent follow-up. It is intended to assess patient status across seven functional categories: alcohol and substance use, physical and mental wellbeing, work, support, family relationships, and illegal activity. ASI is translated into Arabic and validated by Qassem et al. (2004) in the Institute of Psychiatry, Ain-Shams University Hospitals .
Drug Screen in urine: Urine specimens were collected in clean and dry plastic containers at room temperature. We used the Multi-Drug One Step Screen Test Panel (Urine), a lateral flow chromatographic immunoassay for the qualitative detection of the following four drugs: (Tetrahydrocannabinol, Opiates, Tramadol, Benzodiazepines).
Statistical analysis was done using SPSS Statistics for Windows, Version 27. IBM Corp. 2020 . Data were presented in tables and a figure. We used the mean, median, standard deviation, and range for giving Quantitative variables. Qualitative variables were shown as frequencies and proportions. To analyze qualitative data, we used Pearson’s chi-square (χ2) test. When appropriate, Student’s t-test (T) and Mann Whitney test (MW) were used to analyze continuous data between two groups. But we used Kruskal–Wallis H (KW) tests to analyze continuous data between more than two groups. To find the correlation between continuous variables, Spearman’s correlation coefficient (r) was used. In all tests, a P-value of ˂ 0.05 was accepted as statistically significant.
The studied patients had a mean age of 35.5 years old, 80.0% were males, 49.7% were single, 35.2% had secondary education, 78.2% were none working, 70.9% were rural residents, 44.8% were low socioeconomic class, the mean age of onset of schizophrenia was 22.8 years old, mean duration of disease was 13.2 years, 40.6% were hospitalized once, the prevalence of lifetime substance use was 41.2%, 45.5% were smokers, mean PANSS positive was 16.2, mean PANSS negative was 17.5, mean PANSS general was 33.7, mean Compliance Rating Scale was 4.5, and the mean simple score of WHODAS was 32.5. Positive substance abuse screening prevalence in the studied patients was 18.2% (Table 1).
The most frequent adverse childhood experiences were the mother or household member being treated violently (60.6%), emotional neglect (40.0%), physical abuse (25.5%), and contact sexual abuse (22.4%). The mean ACE score (binary version) was 3.7 (Table 2).
Only 14.4% of the studied patients had zero ACE. This means that 85.6% of the studied patients had at least one ACE. Almost one-quarter of the studied patients had ≥ 4 ACEs (Fig. 1).
Among the screening positive patients, 76.7% were positive for cannabis only, and the rest were positive for both cannabis and tramadol. 83.3% had a daily intake of the addicted substance, mean age of onset of substance use was 19.8 years old, mean duration of substance use was 10.6 years, 63.3% reported Abstinence, 13.3% reported hospitalization due to substance use. The median addiction severity index was 28.5 (Table 3, Fig. 2).
There were statistically significant negative correlations between total ACE score and educational level, socioeconomic level, and age of onset of schizophrenia (Table 4). On the other hand, statistically significant positive correlations between total ACE score and PANSS positive and addiction severity index.
There were statistically significant associations between ACE type and characteristics of the studied patients (Table 5). The first most frequent ACE (Mother or Household member treated violently) was significantly associated with female gender (87.9%), education level other than high education (73.9%, 72.7%, 70.7%), low and middle socioeconomic classes (77.0%, 61.5%), lifetime substance use (75.0%), smokers (85.6%) and positive drug screening (80.0%).
Emotional neglect was significantly associated with low and preparatory education (82.6%, 75.8%), low socioeconomic class (58.1%), smokers and ex-smokers (46.7%, 58.8%), and positive drug screening (63.3%).
Physical abuse was significantly associated with divorced patients (72.0%), low and preparatory education (60.9%, 63.6%), rural residents (29.9%), lifetime substance use (50.0%), and positive drug screening (43.3%).
Contact sexual abuse was significantly associated with female gender (57.6%), low and preparatory education (39.1%, 42.4%), rural residents (28.2%), low socioeconomic class (31.1%), and positive drug screening (36.7%).
Adverse childhood experiences (ACEs) have been attributed to harmful health behaviors and the risk of chronic diseases in adulthood. This research investigated the relationship between ACEs and substance use disorders in patients with schizophrenia. In the current study, only 14.4% of the studied patients had zero ACE. This means that 85.6% of the studied patients had at least one ACE. Almost one-quarter of the studied patients had ≥ 4 ACEs.
In line with our study, Schalinski et al. (2017) found that 80.5% of patients with schizophrenia had at least one type of childhood trauma, and 48.9% had more than two types of traumas. In addition, 18.3% and 13.3% had one and two types of traumas, respectively, while 19.4% of Schizophrenia patients had no ACE .
On the other hand, Andrianarisoa et al. (2017) reported a high prevalence of childhood trauma (82.5%) among schizophrenic patients . This high prevalence can be explained because even mild childhood trauma was included in the childhood trauma group.
The frequency of childhood adverse experiences in patients with schizophrenia varied across the studies [24,25,26,27,28]. It ranged from 50 to 94%. The disparities may be attributed to various reasons, including diverse demographics, multiple decades of assessment, disparate scales for evaluating childhood trauma, recall bias, sample size, and different countries and cultures. Additionally, other demographic characteristics may clarify the higher childhood trauma rates because childhood trauma questionnaires examine various experiences, the majority of which are linked to social status and educational level.
In the present study, the most frequent adverse childhood experiences were the mother, or household member treated violently (60.6%), emotional neglect (40.0%), physical abuse (25.5%), and contact sexual abuse (22.4%).
In a study of male patients with schizophrenia, the most often reported subtype of the adverse incident was psychiatric illness among family members (72.5%), followed by the separation, divorce, or mortality of the parents (58.8%), emotional negligence (54.9%), and physical neglect (43.6%). Sexual abuse and imprisonment of a family member were uncommon (19.6% and 29%, respectively) .
In a study of adults with Schizophrenia, Rosenberg et al. (2007) found that the most common form of adverse childhood event was child physical abuse (56%), followed by witnessing domestic violence (49%), parental separation, or divorce (36%), child sexual abuse (34%), and parental mental illness (21%) .
A meta-analysis study by Read et al. (2005) reported that psychotic patients had a high prevalence of childhood sexual and physical abuse. Sexual abuse was 48% among females and 28% among males. Physical abuse was 48% among females and 50% among males . In addition, other pieces of literature reported that emotional abuse and neglect are more common in schizophrenia than physical abuse or neglect [25, 29,30,31,32].
We may explain the high prevalence of domestic violence in Egypt that violent behavior is typical against wives, especially in low socioeconomic status and a widely accepted cultural practice compared to high-income countries. Besides, the prevalence of recorded sexual abuse is somewhat lower in this study, primarily due to societal taboos and shame associated with child sexual abuse.
The current study found statistically significant negative correlations between total ACE score, educational level, and socioeconomic level. In agreement with the present study, Alvarez et al. (2011) and Schenkel et al. (2005) and found an association between childhood trauma and lower educational level, history of school difficulty, and these findings are similar to our results [8, 33].
In contrast, Vallejos et al. (2017) and Rosenberg et al. (2007) found no statistically significant difference in the level of education among patients who suffered multiple adverse events [27, 28]. A study done by Gil et al. (2009) showed that childhood trauma had no association with sociodemographic variables .
The current study found statistically significant negative correlations between total ACE score and age of onset of schizophrenia. These findings were in line with other literature [22, 25, 35,36,37,38]. The start of schizophrenia was earlier if the patients had been subjected to adverse childhood experiences. This result was significant only in cases of physical abuse within the abuse-specific subgroups .
Another study revealed that patients with a history of abuse, regardless of gender, have a significantly younger age of onset. In contrast, physical trauma appears to be a critical factor in accelerating the onset of schizophrenia, particularly in females . In comparison, Rajkumar (2015) reported that age of onset was not correlated with the ACE scores .
There were statistically significant positive correlations between total ACE score and PANSS positive. In contrast, Longden et al. (2016) found a significant correlation between childhood trauma with positive symptoms and negative symptoms of schizophrenia. This difference from our study can be explained by studying the effect of different categories of childhood adversities on negative symptoms. This significant correlation is found with physical and emotional abuse only .
The current study found no statistically significant correlation between ACE score and WHODAS simple score. In agreement with our results, Rajkumar (2015) and Duhig et al. (2015) found that there was no significant relationship between childhood trauma and social, vocational, or overall functioning [29, 30].
On the other hand, Baudin et al. (2016), Gil et al. (2009), and Rosenberg et al. (2007) found that childhood trauma had an association with increased disability in adulthood presented by a statistically significant negative correlation between childhood trauma and overall functioning [34, 42]. This variation can be explained by different methodologies. Using the WHO Disability Assessment Scale criteria, impairment refers to interference in one's ability to function in six domains: cognition, mobility, self-care, getting along, life activities, and community participation.
Our study showed that there is no statistically significant correlation between ACE and medication adherence. In contrast, Lecomte et al. (2008) found that patients exposed to childhood trauma had lower compliance with treatment . It can be explained by the presence of different variables influencing medication adherence. A robust familial support system following the first hospitalization has been found to deflect the impact of social and internalized stigma. Therefore, it can lead to a quicker recovery with greater ease in following treatment guidelines. Personal beliefs and attitudes about medication and psychiatric services have influenced treatment adherence and can be modified using cognitive-behavioral strategies. Also, specific personality traits, primarily being high in agreeableness, were linked to poor medication adherence. It can also be connected to a higher likelihood of being influenced by peers and eagerness to be accepted in a group and avoid social rejection linked to psychosis.
The current study found no statistically significant correlation between ACE score and frequency of hospitalization, which was consistent with other studies [22, 27]. In contrast, some studies revealed that a history of childhood abuse was associated with a more significant number of previous hospitalizations and earlier at first hospitalization [28, 33]. These findings may be explained by patients having difficulties recalling this detail since most participants in this study had been treated for several years; they could also be explained by subjects choosing not to share particular events, experiences, or personal behaviors .
The current study found statistically significant associations between the type of ACE and the characteristics of the studied patients. Yildirim et al. (2014) found that patients with primary school education were higher in patients with emotional neglect history . Rajkumar. (2015) found that Childhood trauma was unrelated to one's childhood residence (rural or urban) and had no statistically significant correlation with overall years of education. And these findings were different from our findings . Our result may be explained that rural areas have a lower social status and education level than towns. Thus, parents are preoccupied with earning a living and lack the time necessary to provide for their children, raising the likelihood of feeling neglected by their parents.
The prevalence of positive substance abuse screening in the studied patients was 18.2%. Almost three-quarters of them were positive for cannabis only, and the rest were positive for both cannabis and tramadol. There were statistically significant positive correlations between total ACE score and addiction severity index.
These results were consistent with Lasalvia et al. (2012), who found that 20.3% of schizophrenic patients were positive for substance abuse, and the most used drug was cannabis .
Besides, Margolese et al. (2004) found that 44.9% of schizophrenic patients fulfilled the criteria for lifelong drug misuse, and 14.0% fulfilled the criteria for current abuse/dependence and reported that the most often consumed drugs were alcohol and cannabis .
According to an Egyptian study by Asaad et al. (2003), 26% of schizophrenic patients met DSM-5 guidelines for drug misuse. Anti-parkinsonian medications were the most often abused substance, followed by cannabinoids, opioids, and benzodiazepines .
On the other hand, Swartz et al. (2006) incorporated radioimmunoassay of hair specimens and urine drug tests into diagnostic assessments combined with self-report measures. They reported that 37% of patients were diagnosed as having current substance use disorder .
The wide variance of the comorbid substance abuse prevalence in schizophrenia is based on the diagnostic evaluation techniques used, the presence of collateral informants, and the laboratory assessment techniques. Also, the high prevalence of alcohol misuse in western countries, which was not measured in this study, may lead to a high prevalence of substance use in other studies. Another cause for this variance is different cultures and legal constraints across countries.
Limitations: The cross-sectional design used by this study made it difficult to disentangle the effect of substance; for example, cannabis may result in psychotic experiences, but psychotic experiences may also result in the individual using cannabis to reduce the incidents of psychosis. So future longitudinal studies need to be done.
History of childhood trauma may also be associated with other co-morbidities, including post-traumatic stress disorder (PTSD), which may be targeted by specific psychotherapies, such as trauma-focused cognitive behavioral therapy. PTSD has not been evaluated in the present study, which is a clear limit and should be considered in further studies.
Our study lacked a control group, and we are therefore unable to comment on whether the patients in our sample experienced higher levels of childhood trauma or substance abuse than appropriately matched controls from the same population.
Finally, the current study’s findings indicate that childhood adverse experiences and substance abuse are prevalent problems in patients with schizophrenia. Given the association between both issues, they may affect the symptomatology of the disorder, the prognosis, and the therapeutic plan. It is advised that a greater emphasis on and identification of childhood trauma and drug use disorder may be a necessary step in assessing patients with schizophrenia. Further studies were needed using analytical design and larger sample sizes. More research is required to document better the link between ACEs and overall health and wellbeing in Egypt.
Availability of data and materials
Adverse Childhood Experiences International Questionnaire
- WHODAS 2.0:
World Health Organization Disability Assessment Schedule 2.0
American Psychiatric Association
Addiction Severity Index
Compliance Rating Scale
Diagnostic and Statistical Manual of Mental Disorders-fifth edition
Mann Whitney test
Positive and Negative Syndrome Scale
- SCID-5 -RV:
Structured Clinical Interview for DSM-5 (Research Version)
Statistical Package for Social Science
Substance use disorder
- t :
World Health Organization
- WHODAS 2.0:
World Health Organization Disability Assessment Schedule 2.0
- χ 2 :
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The authors would like to thank all the study participants.
The authors declare that they have no funding support.
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Official permissions were obtained from Institutional Review Board at the Faculty of Medicine, Zagazig University hospitals with Reference Number (ZU-IRB#5056) on 6-1-2019, and the Psychiatry Department same University. A written informed consent was obtained from all participants, and they had the right to withdraw from the study at any time and without negatively affecting their medical care. The results of this study could be used as a scientific publication, but the participant's identity will be confidential.
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Yousef, A.M., Mohamed, A.E., Eldeeb, S.M. et al. Prevalence and clinical implication of adverse childhood experiences and their association with substance use disorder among patients with schizophrenia. Egypt J Neurol Psychiatry Neurosurg 58, 4 (2022). https://doi.org/10.1186/s41983-021-00441-x
- Adverse childhood experiences
- Substance abuse