Articles

Salivary alpha-synuclein (total and oligomeric form): potential biomarkers in Parkinson’s disease

Parkinson’s disease (PD) is one of the most common degenerative diseases of the central nervous system (CNS). Alpha-synuclein (A-syn) plays a critical role in the pathogenesis of PD. The close relation between...

Authors: Hala Shaheen, Sayed Sobhy, Sherine El Mously, Marwa Abuomira and Mohamed Mansour

Detection of airway protective level of the cough reflex in acute stroke patients

The most common respiratory complications in cerebrovascular strokes were respiratory infection, pulmonary edema, acute lung injury (ALI) acute respiratory distress syndrome (ARDS) and pulmonary embolism (PE)....

Authors: Ehab Shaker Belal, Samah Selim, Alshaimaa M. Aboul fotouh and Asmaa Mohammad

Polyunsaturated fatty acids supplementation can improve specific language impairment in preschool children: a pilot study

Speech and language are one of the higher cognitive brain functions. Language delay is one of the major concerns of child health in Egypt. Speech therapy is the standard management in language delay.

Authors: Dalia G. Yasseen, Nermien E. Waly and Khaled O. Abdulghani

The role of left prefrontal transcranial magnetic stimulation in episodic migraine prophylaxis

The aim of the study was to examine the prophylactic role of repetitive transcranial magnetic stimulation (rTMS) on the frequency, and severity of migraine attacks in episodic migraineurs who failed medical tr...

Authors: Randa Amin, Tamer Emara, Samia Ashour, Mahmoud Hemeda, Nahed Salah Eldin, Salma Hamed, Sara Shouman and Mohamed Shouman

Impact of insulin resistance and metabolic syndrome on disability in patients with multiple sclerosis

Currently, little is known regarding the association of metabolic comorbidities and disability among multiple sclerosis (MS) patients.

Authors: Rasha Hassan Soliman, Hanan Mohamed Farhan, Mohamed Hegazy, Mohammed Ibrahim Oraby, Shaimaa Hossam Kamel and Amr Hassan

Neutrophil–lymphocyte ratio and response to plasmapheresis in Guillain–Barré syndrome: a prospective observational study

Guillain–Barré Syndrome (GBS) is one of the most severe neurological diseases that causes marked disability and even death.

Authors: Noha Ali Hashim, Wafaa Samir Mohamed and Engy Mohammed Emad

Cognitive performance in patients with chronic tension-type headache and its relation to neuroendocrine hormones

Tension-type headache is the most common headache to be seen in clinical practice. Depression is highly prevalent in chronic tension-type headache (CTTH) patients attending the clinical settings. Cognitive imp...

Authors: Mamdouh Ali Kotb, Ahmed M. Kamal, Daifallah Al-Malki, Aliaa S. Abd El Fatah and Yassmin M. Ahmed

Systemic lupus erythematosus presenting with status epilepticus and acute cardiomyopathy with acute heart failure: case report

Systemic lupus erythematosus is a connective tissue disorder, which causes complex multi organ involvement. Neurological and cardiac manifestations have been well noted but complications such as status epilept...

Authors: H. M. M. T. B. Herath and Aruna Kulatunga

Heart versus brain: a case of ictal asystole in temporal lobe epilepsy

Ictal asystole is a rare phenomenon. Most reported cases are in persons with long-standing focal epilepsy originating from the temporal lobe. Its occurrence may complicate the clinical presentation or delay di...

Authors: Ahmed Yassin, Belal Aldabbour, Anto Bagić and Alexandra Urban

Post-stroke sleep disorders in Egyptian patients by using simply administered questionnaires: a study from Ain Shams University

Stroke is a leading cause of disability worldwide with grave morbidity and mortality. Sleep and stroke have a definite intermingling neuropathological relationship, so along with expeditious acute management, ...

Authors: Alia H. Mansour, Maged Ayad, Naglaa El-Khayat, Ahmed El Sadek and Taha K. Alloush

Role of interleukin-6 in ischemic stroke outcome

High levels of inflammatory markers such as C-reactive protein (CRP) and interleukin (IL)-6 are associated with worse outcome after ischemic stroke.

Authors: Hani Mohamed Amin Aref, Nagia Ali Fahmy, Salma Hamed Khalil, Mai Fathy Ahmed, Ahmed ElSadek and Mohamed Osama Abdulghani

Characteristics of A-waves in patients with amyotrophic lateral sclerosis (ALS) versus demyelinating neuropathies (DN)

Detect the occurrence and characteristics of A-waves in amyotrophic lateral sclerosis (ALS) and demyelinating neuropathies (DN).

Authors: Hebatallah R Rashed

Value of magnetic resonance spectroscopy in geriatric patients with cognitive impairment

Mild cognitive impairment is a transitional stage prior to dementia, and it is reported in depressed patients. Early diagnosis could predict the reversible etiologies and prevent further deterioration. Proton ...

Authors: Mamdouh Ali Kotb, Ahmed M. Kamal, Nasser M. Aldossary, Ayman A. Alsify and Yassmin M. Ahmed

Gender difference in health issues and cognitive functions among an Egyptian normal elderly population

Aging is associated with changes in cognitive functions. However, many other factors may affect cognitive functions and this interaction needs further assessment.

Authors: Enas Alsayyad, Azza Abbas Helmy, Nirmeen A. Kishk, Marwa Farghaly, Amany H. Ragab and Shaimaa Ibrahim El-Jaafary

The myth and truth of a comprehensive stroke scale

The National Institutes of Health Stroke Scale (NIHSS) has been found to be biased toward the left hemispheric and motoric functions providing minimal assessment to the right hemispheric language and cognitive...

Authors: Hani M. Zakieldine, Mohamed A. Turk, Rana F. Hashem and Mohamed A. Shafik

Do cerebral microbleeds affect cognition in patients with symptomatic small vessel disease?

Dementia and cognitive impairment are becoming increasingly a major health problem, pronounced by increased life expectancy. Cerebral small vessel disease (cSVD) is among the major causes of cognitive deterior...

Authors: Kholoud Mahmoud Abdullah, Hany Mahmoud Zakieldin, Iman Mohamed Bayomy, Maryse Youssef Awadallah and Mona Mokhtar Wahid El Din

Natalizumab-induced hyporegenerative anaemia and leukopenia: a case report

Authors: Salman Mansoor, Siobhan Kelly, Aine Burke, Mohammad Hijaz Adenan, Eimear Joyce, Aine Waters, Grainne McPartland and Kevin Murphy

Sleep pattern in epilepsy patients: a polysomnographic study

Sleep disorders and epilepsy commonly exist and affect each other. Patients with epilepsy often complain of poor sleep and on the other hand, poor sleep makes epilepsy control difficult.

Authors: Mohamed A. Tork, Hebatallah R. Rashed, Lobna Elnabil, Nahed Salah-Eldin, Naglaa Elkhayat, Ayman A. Abdelhady, M. Ossama Abdulghani and Khaled O. Abdulghani

One-year evaluation of epiduroscopy in chronic back pain with and without radiculopathy: a retrospective study

Back pain is a frequent complaint among the individuals in the society. It significantly affects the daily activities and the social and psychological life aspects leading to an economic health burden. Epiduro...

Authors: Mert Akbas, Huseyin Babun, Haitham Hamdy Salem, Tamer Hussien Emara, Shereen Elmosly, Emel Gunduz, Bilge Karsli and Fatih Asik

Serum apolipoprotein A1: a predictor and prognostic biomarker in acute ischemic stroke

The apolipoprotein A1 level is recognized as a better indicator of cardiovascular disease than other cholesterol measures.

Authors: Mai A. Eldeeb, Amr S. Zaki, Samia Ashour, Azza Abdel Nasser, Ahmed El Bassiouny and Khaled O. Abdulghani

A hospital-based study of post-stroke aphasia: frequency, risk factors, and topographic representation

The crude prevalence rate of stroke in Qena, Egypt, is high (922/100,000). For the first time, we estimate the frequency of aphasia following the first-ever ischemic stroke and its relationship to the site of ...

Authors: Eman M. Khedr, Mohamed A. Abbass, Radwa K. Soliman, Ahmed F. Zaki, Aymen Gamea, Noha Abo El-Fetoh and Mahmoud A. Abdel-Aaal

Blood biomarkers for stroke: the role of thioredoxin in diagnosis and prognosis of acute ischemic stroke

Oxidative stress plays a crucial role in the pathophysiology of acute ischemic stroke. Thioredoxin exists and released from cells during inflammation and oxidative stress and was recognized as an oxidative-str...

Authors: Mohammed I. Oraby and Radwa A. Rabie

Influence of pelvic inclination on sit to stand task in stroke patients

Stroke results in an impaired sit to stand (STS) task. Pelvic movements are essential in daily living activities. Few studies investigated the effect of spine and pelvis separately on functional activities in ...

Authors: Moshera Hassan Darwish, Sandra Ahmed, Manar El-sayed Ismail and Heba Ahmed Khalifa

Oligoclonal bands and levels of interleukin 4, interleukin 10, and tumor necrosis factor alpha in idiopathic intracranial hypertension Egyptian patients

Idiopathic intracranial hypertension (IIH) is a neurological disorder of unknown pathophysiology with many proposed theories that involve CSF dynamics but recently, involvement of inflammatory and autoimmune p...

Authors: Mohamed S. El-Tamawy, Maha A. Zaki, Laila A. Rashed, Eman H. Esmail, Shaimaa Shaheen Mohamed and Wesam Osama

Cerebral hemodynamics among non-diabetic hemodialysis patients

Cerebrovascular accidents and cognitive impairment is a frequent complication of end-stage renal disease (ESRD) on regular hemodialysis (HD).

Authors: Maha Abdelmoneim Behairy, Ahmed ElSadek, Mahmoud Sadek and Abdelbassit El Shaarawy

Stress hyperglycemia and electrolytes disturbance in patients with acute cerebrovascular stroke

Stroke is a medical emergency and considered the 2nd leading cause of mortality worldwide. High morbidity and mortality of stroke are due to some complications like cerebral edema, infection, and associated he...

Authors: Bastawy M. El-Fawal, Reda Badry, Wael A. Abbas and Ahmed K. Ibrahim

Cerebellar glioblastoma multiforme in an adult patient with neurofibromatosis type 1: an extremely rare report with review of literature

Neurofibromatosis type 1 (NF1) is a multisystem genetic disorder with autosomal dominant inheritance which predisposes the affected individuals to increased risk of developing certain benign and malignant cent...

Authors: Nima Derakhshan, Nazanin Azadeh, Arash Saffarian, Mousa Taghipour, Keyvan Eghbal and Amirreza Dehghanian

Sensor driven-position adaptive versus conventional spinal cord stimulation in failed back surgery syndrome: a retrospective case series

Failed back surgery syndrome (FBSS) is a common problem affecting 20–40% of cases undergoing spine surgeries. Spinal cord stimulation (SCS) has been shown to be an efficient and relatively safe treatment in ma...

Authors: Mert Akbas, Haitham Hamdy Salem, Tamer Hussien Emara, Bora Dinc and Bilge Karsli

Occurrence of Guillain-Barré syndrome and Myasthenia Gravis in an elderly male

The occurrence of both Guillain-Barré syndrome(GBS) and myasthenia gravis (MG) in the same individual is rare. The underlying pathophysiology was assumed to be autoimmune humoral mechanisms and molecular mimic...

Authors: Madhavi Karri, Balakrishnan Ramasamy and Santhosh Perumal

Serum and urine ghrelin in adult epileptic patients

Several neuropeptides have concerned with epilepsy pathogenesis; ghrelin showed an anticonvulsant effect. There is a potential relation between its level and antiepileptic drug (AEDs) response.

Authors: Wafaa S. Mohamed, Rania S. Nageeb and Hanaa H. Elsaid

Placement of a single anterior odontoid screw for type II odontoid fractures in a setting with limited resources

Treatment of odontoid fractures with odontoid screws is an established method for fusion. However, it is facilitated by using advanced equipment in the operating theatre not always available as in developing c...

Authors: Ahmed Hamdy Ashry and Hashem Mohamed Aboul-Ela

Serum vitamin D levels in acute stroke patients

Vitamin D deficiency has been proposed as a risk factors of cerebrovascular stroke.

Authors: Fayrouz O. Selim, Rasha M. Fahmi, Ayman E. Ali, Nermin Raafat and Ahmed F. Elsaid

Isolated unilateral palatal and vocal cord palsy as an initial presentation of chronic inflammatory demyelinating polyradiculoneuropathy

Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an acquired autoimmune disease of the peripheral nervous system. Its clinical presentation and excellent response to steroids is a hallmark t...

Authors: Madhavi Karri and Balakrishnan Ramasamy

Role of short-term video electroencephalogram in monitoring seizure diagnosis

Authors: Mona Mohamed Abdel Moneim Nada, Heba Raafat, Mohamed Khaled Al Menabbawy, Manal Mohamed Moussa and Omar El-Nakah

Efficacy of spinal extension exercise program versus muscle energy technique in treatment of chronic mechanical low back pain

Mechanical low back pain (MLBP) is a major cause of illness and disability, especially in people of working age. People with chronic low back pain often experience anger, fear, anxiety, decrease in physical ab...

Authors: E. Fahmy, H. Shaker, W. Ragab, H. Helmy and M. Gaber

Evaluation of inflammatory markers and mean platelet volume as short-term outcome indicators in young adults with ischemic stroke

Studying outcome predictors in patients with onset of cerebral infarction in early adult life may enhance our knowledge of disease pathophysiology and prognosis.

Authors: Ahmed Dahshan, Asmaa M. Ebraheim, Laila A. Rashed, Mohammed A. Farrag and Ahmed T. El Ghoneimy

The role of s100b as a predictor of the functional outcome in geriatric patients with acute cerebrovascular stroke

Authors: Walae E. Abdel-Ghaffar, Sekina Ahmed, Ehab Mahmoud El reweny, Amr Elfatatry, Mona Elmesky and Doaa Hashad

Microsurgical unilateral laminotomy for bilateral decompression of degenerative lumbar canal stenosis: a comparative study

The quest for better patient outcomes is driving to the development of minimally invasive spine surgical techniques. There are several evidences on the use of microsurgical decompression surgery for degenerati...

Authors: Mohamed I. Refaat, Amr K. Elsamman, Adham Rabea and Mohamed I. A. Hewaidy

The role of intraoperative ultrasound in gross total resection of brain mass lesions and outcome

Surgical resection of brain mass lesion mandates safety and the best outcome for the patient.

Authors: Wael Abd Elrahman Ali Elmesallamy

Predictive value of C-reactive protein and carotid intimal medial thickness in acute ischemic stroke

Elevated CRP and increased CCA-IMT are both associated with the occurrence of stroke. CRP and IMT are closely associated; the higher the CRP, the greater the carotid atherosclerosis as measured by carotid IMT.

Authors: Mahmoud Elbelkimy, Naglaa ELkhayat, Ahmed ElSadek, Alia Mansour and Mariam Aboutaleb

Assessment of bee venom therapy in animal model of statin-induced myopathy

Statin-induced myopathy is the most common adverse effect of statins. Bee venom provides a potential mean of controlling immune responses and inflammatory reactions; the proposed mechanisms for statin-induced ...

Authors: Ann Abdel Kader, Radwa Azmy, Eman A. Maher, Basma Bahgat El Sayed, Alshaimaa Sobhi Khalil, Mohammad Ghalwash and Manal Mahmoud

The effects of kinesio taping of lower limbs on functional mobility, spasticity, and range of motion of children with spastic cerebral palsy

Cerebral palsy (CP) is a non-progressive neurological disease in a growing brain.

Authors: Mirjavad Tabatabaee, Moslem Cheraghifard and Alireza Shamsoddini

H-reflex latency changes after combined application of traction and neural mobilization in cervical radiculopathy

Cervical radiculopathy is a pathology of the cervical nerve root and mostly caused by a cervical disk herniation leading to chronic pain and disability.

Authors: Mohammed M. Hegazy, Ebtessam F. Gomaa, Salwa F. Abd El Mageed and Hala R. El Habashy

Cardio embolic stroke and blood biomarkers: diagnosis and predictors of short-term outcome

The brain is a productive source of a variety of enzymes and any brain injury like a stroke to brain tissue could similarly result in an increase in these enzymes in cerebrospinal fluid and serum. Evaluation o...

Authors: Wafaa S. Mohamed, Elhady A. Abd ElGawad, Amal SE. ElMotayam and Sabah E. Fathy

Lower limb weakness with gyrus rectus hematoma: an unusual presentation of paraclinoid aneurysm; a case report with review of literature

Lower limb weakness is usually a feature of ruptured anterior communicating (ACom) aneurysms due to spasm of the anterior cerebral arteries. Paraclinoid aneurysms, in addition to other cardinal features of sub...

Authors: Amey P. Patankar and Maulik Vaja

Assessment of the optic nerve and its arterial supply by ultrasound imaging in multiple sclerosis patients

Transorbital sonography (TOS) has emerged as a promising assessment tool of the optic nerve and orbital arterial supply in multiple sclerosis (MS) patients.

Authors: Manal Mahmoud Al Kattan, Amira Ahmed Labib, Rania Shehata Ismail, Alshaimaa M. Aboul fotouh and Emad El Din Mostafa Mohammed

Screening for cognitive impairment in Arabic-speaking Hajj pilgrims

Although cognitive impairment is common in the elderly population, studies investigating its rate in Hajj pilgrims are lacking.

Authors: Ahmad S. Alzahrani, Faisal Alhumaidi, Abdulaziz Altowairqi, Waad Al-Malki and Israa AlFadhli

Early functional outcome after IV rTPA administration in Egyptian acute ischemic stroke patients

Intravenous thrombolysis has become a standard practice in eligible patients with acute ischemic stroke (AIS). Functional outcome after AIS is a major concern for patients, families, and neurologists. Identify...

Authors: Mohamed A. Elsayed, Husam Salah, Asmaa Sabbah, Ghada Hatem and Mona K. Moawad

Quantitative d-dimer level and anticoagulant therapy in idiopathic intracranial hypertension

Idiopathic intracranial hypertension (IIH) is a syndrome characterized by elevated intracranial pressure (ICP) of unknown etiology

Authors: Hala Shaheen, Sayed Sobhy, Sherine El Mously, Mohamed El Khatib and Amany Hamdy

The emerging role of serum zinc in motor disability and radiological findings in patients with multiple sclerosis

The role of serum Zinc in the pathogenesis of relapsing remittent multiple sclerosis (RRMS) and its impact on motor disability and radiological findings remains a matter of debate.

Authors: Mohammed I. Oraby, Mona Hussein, Rehab Abd Elkareem and Eman Elfar