Chan KY, Wang W, Wu JJ, Liu L, Theodoratou E, Car J, et al. Epidemiology of Alzheimer's disease and other forms of dementia in China, 1990–2010: a systematic review and analysis. Lancet. 2013;381(9882):2016–23.
Article
PubMed
Google Scholar
Lin JS, O’Connor E, Rossom RC, Perdue LA, Eckstrom E. Screening for cognitive impairment in older adults: a systematic review for the US Preventive Services Task Force. Ann Internal Med. 2013;159(9):601–12.
Google Scholar
Etgen T, Sander D, Bickel H, Förstl H. Mild cognitive impairment and dementia: the importance of modifiable risk factors. Dtsch Arztebl Int. 2011;108(44):743.
PubMed
PubMed Central
Google Scholar
Reischies FM, Neu P. Comorbidity of mild cognitive disorder and depression–a neuropsychological analysis. Eur Arch Psychiatry Clin Neurosci. 2000;250(4):186–93.
Article
CAS
PubMed
Google Scholar
Evans M, Mottram P. Diagnosis of depression in elderly patients. Adv Psychiatr Treatment. 2000;6(1):49–56.
Article
Google Scholar
Gottfries CG. Late life depression. Eur Arch Psychiatry Clin Neurosci. 2001;251(Suppl 2):II57–61.
Article
PubMed
Google Scholar
Rangaswamy S. World Health Report: Mental health: new understanding new hope. Geneva: The World Health Organization; 2001.
Google Scholar
Wig NN. World health day 2001. Ind J Psychiatry. 2001;43(1):1.
CAS
Google Scholar
Chetelat G, Desgranges B, De La Sayette V, Viader F, Eustache F, Baron J-C. Mild cognitive impairment: can FDG-PET predict who is to rapidly convert to Alzheimer’s disease? Neurology. 2003;60(8):1374–7.
Article
CAS
PubMed
Google Scholar
Drzezga A, Lautenschlager N, Siebner H, Riemenschneider M, Willoch F, Minoshima S, et al. Cerebral metabolic changes accompanying conversion of mild cognitive impairment into Alzheimer’s disease: a PET follow-up study. Eur J Nucl Med Mol Imaging. 2003;30(8):1104–13.
Article
PubMed
Google Scholar
Chincarini A, Bosco P, Calvini P, Gemme G, Esposito M, Olivieri C, et al. Local MRI analysis approach in the diagnosis of early and prodromal Alzheimer’s disease. Neuroimage. 2011;58(2):469–80.
Article
PubMed
Google Scholar
Liu Y, Paajanen T, Zhang Y, Westman E, Wahlund L-O, Simmons A, et al. Analysis of regional MRI volumes and thicknesses as predictors of conversion from mild cognitive impairment to Alzheimer's disease. Neurobiol Aging. 2010;31(8):1375–85.
Article
PubMed
Google Scholar
O’brien J. Role of imaging techniques in the diagnosis of dementia. Br J Radiol. 2007;80(special_issue_2):S71–S7.
Article
PubMed
Google Scholar
Li T-Q, Wahlund L-O. The search for neuroimaging biomarkers of Alzheimer’s disease with advanced MRI techniques. Acta Radiologica. 2011;52(2):211–22.
Article
PubMed
Google Scholar
Targosz-Gajniak MG, Siuda JS, Wicher MM, Banasik TJ, Bujak MA, Augusciak-Duma AM, et al. Magnetic resonance spectroscopy as a predictor of conversion of mild cognitive impairment to dementia. J Neurol Sci. 2013;335(1-2):58–63.
Article
PubMed
Google Scholar
McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA Work Group* under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease. Neurology. 1984;34(7):939.
Article
CAS
PubMed
Google Scholar
Morris JC. The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology. 1993.
Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, Kokmen E. Mild cognitive impairment: clinical characterization and outcome. Arch Neurol. 1999;56(3):303–8.
Article
CAS
PubMed
Google Scholar
Edition F. Diagnostic and statistical manual of mental disorders. Am Psychiatric Assoc. 2013.
Leyhe T, Reynolds CF III, Melcher T, Linnemann C, Klöppel S, Blennow K, et al. A common challenge in older adults: Classification, overlap, and therapy of depression and dementia. Alzheimers Dement. 2017;13(1):59–71.
Article
PubMed
Google Scholar
Greenberg SA. The geriatric depression scale (GDS). Best Pract Nursing Care Older Adults. 2012;4(1):1–2.
Google Scholar
Rahman TTA, El Gaafary MM. Montreal cognitive assessment Arabic version: reliability and validity prevalence of mild cognitive impairment among elderly attending geriatric clubs in Cairo. Geriatr Gerontol Int. 2009;9(1):54–61.
Article
PubMed
Google Scholar
Watanabe T, Shiino A, Akiguchi I. Absolute quantification in proton magnetic resonance spectroscopy is useful to differentiate amnesic mild cognitive impairment from Alzheimer’s disease and healthy aging. Dement Geriatr Cogn Disord. 2010;30(1):71–7.
Article
CAS
PubMed
Google Scholar
Tumati S, Martens S, Aleman A. Magnetic resonance spectroscopy in mild cognitive impairment: systematic review and meta-analysis. Neurosci Biobehav Rev. 2013;37(10):2571–86.
Article
PubMed
Google Scholar
Jessen F, Gür O, Block W, Ende G, Frölich L, Hammen T, et al. A multicenter 1H-MRS study of the medial temporal lobe in AD and MCI. Neurology. 2009;72(20):1735–40.
Article
CAS
PubMed
Google Scholar
Foy CM, Daly EM, Glover A, O’Gorman R, Simmons A, Murphy DG, et al. Hippocampal proton MR spectroscopy in early Alzheimer’s disease and mild cognitive impairment. Brain Topogr. 2011;24(3-4):316–22.
Article
PubMed
Google Scholar
Rupsingh R, Borrie M, Smith M, Wells J, Bartha R. Reduced hippocampal glutamate in Alzheimer disease. Neurobiol Aging. 2011;32(5):802–10.
Article
CAS
PubMed
Google Scholar
Graff-Radford J, Kantarci K. Magnetic resonance spectroscopy in Alzheimer’s disease. Neuropsychiatric Dis Treat. 2013;9:687.
Google Scholar
Ackl N, Ising M, Schreiber YA, Atiya M, Sonntag A, Auer DP. Hippocampal metabolic abnormalities in mild cognitive impairment and Alzheimer’s disease. Neurosci Lett. 2005;384(1-2):23–8.
Article
CAS
PubMed
Google Scholar
Yildiz-Yesiloglu A, Ankerst DP. Review of 1H magnetic resonance spectroscopy findings in major depressive disorder: a meta-analysis. Psychiatry Res. 2006;147(1):1–25.
Article
CAS
PubMed
Google Scholar
Block W, Träber F, von Widdern O, Metten M, Schild H, Maier W, et al. Proton MR spectroscopy of the hippocampus at 3 T in patients with unipolar major depressive disorder: correlates and predictors of treatment response. Int J Neuropsychopharmacol. 2009;12(3):415–22.
Article
CAS
PubMed
Google Scholar
Milne A, MacQueen GM, Yucel K, Soreni N, Hall GB. Hippocampal metabolic abnormalities at first onset and with recurrent episodes of a major depressive disorder: a proton magnetic resonance spectroscopy study. Neuroimage. 2009;47(1):36–41.
Article
PubMed
Google Scholar
Venkatraman TN, Krishnan RR, Steffens DC, Song AW, Taylor WD. Biochemical abnormalities of the medial temporal lobe and medial prefrontal cortex in late-life depression. Psychiatry Res. 2009;172(1):49–54.
Article
CAS
PubMed
PubMed Central
Google Scholar
Dixon RM, Bradley KM, Budge MM, Styles P, Smith AD. Longitudinal quantitative proton magnetic resonance spectroscopy of the hippocampus in Alzheimer’s disease. Brain. 2002;125(10):2332–41.
Article
PubMed
Google Scholar
Block W, Jessen F, Träber F, Flacke S, Manka C, Lamerichs R, et al. Regional N-acetylaspartate reduction in the hippocampus detected with fast proton magnetic resonance spectroscopic imaging in patients with Alzheimer disease. Arch Neurol. 2002;59(5):828–34.
Article
PubMed
Google Scholar
Huang Y, Chen W, Li Y, Wu X, Shi X, Geng D. Effects of antidepressant treatment on N-acetyl aspartate and choline levels in the hippocampus and thalami of post-stroke depression patients: A study using 1H magnetic resonance spectroscopy. Psychiatry Res. 2010;182(1):48–52.
Article
CAS
PubMed
Google Scholar
Xiancang M, Sun Y, Gao C, Sun Q, Ding H, Bolang Y. 1H-MRS in frontal lobe and hippocampus of patients with first episode major depression. J Xi’an Jiaotong Univ (Medical Sciences). 1981;(02).
Golomb J, de Leon MJ, Kluger A, George AE, Tarshish C, Ferris SH. Hippocampal atrophy in normal aging. An association with recent memory impairment. Arch Neurol. 1993;50(9):967–73.
Article
CAS
PubMed
Google Scholar
Braak H, Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathologica. 1991;82(4):239–59.
Article
CAS
PubMed
Google Scholar
Convit A, De Leon M, Golomb J, George A, Tarshish C, Bobinski M, et al. Hippocampal atrophy in early Alzheimer’s disease: anatomic specificity and validation. Psychiatr Q. 1993;64(4):371–87.
Article
CAS
PubMed
Google Scholar
Petersen RC, Jack C, Xu Y-C, Waring S, O’brien P, Smith G, et al. Memory and MRI-based hippocampal volumes in aging and AD. Neurology. 2000;54(3):581.
Article
CAS
PubMed
Google Scholar
Seo SW, Im K, Lee J-M, Kim Y-H, Kim ST, Kim SY, et al. Cortical thickness in single-versus multiple-domain amnestic mild cognitive impairment. Neuroimage. 2007;36(2):289–97.
Article
PubMed
Google Scholar
McEwen BS. Mood disorders and allostatic load. Biol Psychiatry. 2003;54(3):200–7.
Article
PubMed
Google Scholar
Valenzuela MJ, Sachdev P. Magnetic resonance spectroscopy in AD. Neurology. 2001;56(5):592–8.
Article
CAS
PubMed
Google Scholar
Li X, Shao X, Wang N, Wang T, Chen G, Zhou H. Correlation of auditory event-related potentials and magnetic resonance spectroscopy measures in mild cognitive impairment. Brain Res. 2010;1346:204–12.
Article
CAS
PubMed
Google Scholar
Siger M, Schuff N, Zhu X, Miller BL, Weiner MW. Regional myo-inositol concentration in mild cognitive impairment Using 1H magnetic resonance spectroscopic imaging. Alzheimer Dis Assoc Disord. 2009;23(1):57.
Article
CAS
PubMed
PubMed Central
Google Scholar
Chen C-S, Chiang I-C, Li C-W, Lin W-C, Lu C-Y, Hsieh T-J, et al. Proton magnetic resonance spectroscopy of late-life major depressive disorder. Psychiatry Res. 2009;172(3):210–4.
Article
PubMed
Google Scholar
Sözeri-Varma G, Kalkan-Oğuzhanoglu N, Efe M, Kıroglu Y, Duman T. Neurochemical metabolites in prefrontal cortex in patients with mild/moderate levels in first-episode depression. Neuropsychiatr Dis Treat. 2013;9:1053.
Article
PubMed
PubMed Central
Google Scholar
Olvera RL, Caetano SC, Stanley JA, Chen H-H, Nicoletti M, Hatch JP, et al. Reduced medial prefrontal N-Acetyl-Aspartate levels in pediatric major depressive disorder: A multi-voxel in vivo1H spectroscopy study. Psychiatry Res. 2010;184(2):71–6.
Article
CAS
PubMed
PubMed Central
Google Scholar
Suriyajakryuththana W, Tuntiyatorn L, Teepprasarn N, Sukying C. Proton magnetic resonance spectroscopy in mild cognitive impairment and Alzheimer's disease: a preliminary study. J Med Assoc Thai. 2014;97(4):407–14.
PubMed
Google Scholar
Metastasio A, Rinaldi P, Mariani E, Feliziani F, Tarducci R, Gobbi R, et al., editors. Conversion of MCI to dementia: Role of proton magnetic resonance spectroscopy. International Psychogeriatrics. New York: Cambridge Univ Press; 2005.
Google Scholar
Kantarci K, Weigand SD, Petersen RC, Boeve BF, Knopman DS, Gunter J, et al. Longitudinal 1H MRS changes in mild cognitive impairment and Alzheimer’s disease. Neurobiol Aging. 2007;28(9):1330–9.
Article
CAS
PubMed
Google Scholar
Wang Y, Jia Y, Xu G, Ling X, Liu S, Huang L. Frontal white matter biochemical abnormalities in first-episode, treatment-naive patients with major depressive disorder: a proton magnetic resonance spectroscopy study. J Affect Disord. 2012;136(3):620–6.
Article
PubMed
Google Scholar
Mao N, Fang J, Xie H, Liu X, Jiang X, Wang G, et al. Correlation between neurochemical metabolism and memory function in adolescent patients with depression: A multi-voxel 1 H magnetic resonance spectroscopy study. Psychiatry Clin Neurosci. 2016;70(4):167–74.
Article
CAS
PubMed
Google Scholar
Zhang Y, Han Y, Wang Y, Zhang Y, Li L, Jin E, et al. A MRS study of metabolic alterations in the frontal white matter of major depressive disorder patients with the treatment of SSRIs. BMC Psychiatry. 2015;15(1):99.
Article
PubMed
PubMed Central
CAS
Google Scholar
Murata T, Kimura H, Omori M, Kado H, Kosaka H, Iidaka T, et al. MRI white matter hyperintensities, 1H-MR spectroscopy and cognitive function in geriatric depression: a comparison of early-and late-onset cases. Int J Geriatric Psychiatry. 2001;16(12):1129–35.
Article
CAS
Google Scholar
Phillips ML, Drevets WC, Rauch SL, Lane R. Neurobiology of emotion perception II: implications for major psychiatric disorders. Biol Psychiatry. 2003;54(5):515–28.
Article
PubMed
Google Scholar
Ballmaier M, Toga AW, Blanton RE, Sowell ER, Lavretsky H, Peterson J, et al. Anterior cingulate, gyrus rectus, and orbitofrontal abnormalities in elderly depressed patients: an MRI-based parcellation of the prefrontal cortex. Am J Psychiatry. 2004;161(1):99–108.
Article
PubMed
Google Scholar
Taylor WD, MacFall JR, Gerig G, Krishnan RR. Structusral integrity of the uncinate fasciculus in geriatric depression: Relationship with age of onset. Neuropsychiatr Dis Treat. 2007;3(5):669.
PubMed
PubMed Central
Google Scholar
Wolk DA, Dickerson BC, Initiative ADN. Fractionating verbal episodic memory in Alzheimer's disease. Neuroimage. 2011;54(2):1530–9.
Article
PubMed
Google Scholar
Irish M, Addis D, Hodges J, Piguet O. Considering the role of semantic memory in episodic future thinking: Evidence from semantic dementia. Brain. 2012;135(Pt 7):2178–91.
Article
PubMed
Google Scholar
Defrancesco M, Egger K, Marksteiner J, Esterhammer R, Hinterhuber H, Deisenhammer EA, et al. Changes in white matter integrity before conversion from mild cognitive impairment to Alzheimer’s disease. PloS one. 2014;9(8):e106062.
Article
PubMed
PubMed Central
CAS
Google Scholar
Han SD, Houston WS, Jak AJ, Eyler LT, Nagel BJ, Fleisher AS, et al. Verbal paired-associate learning by APOE genotype in non-demented older adults: fMRI evidence of a right hemispheric compensatory response. Neurobiol Aging. 2007;28(2):238–47.
Article
CAS
PubMed
Google Scholar
Erk S, Spottke A, Meisen A, Wagner M, Walter H, Jessen F. Evidence of neuronal compensation during episodic memory in subjective memory impairment. Arch Gen Psychiatry. 2011;68(8):845–52.
Article
PubMed
Google Scholar
Petrella JR, Krishnan S, Slavin MJ, Tran T-TT, Murty L, Doraiswamy PM. Mild cognitive impairment: evaluation with 4-T functional MR imaging. Radiology. 2006;240(1):177–86.
Article
PubMed
Google Scholar
Heun R, Freymann K, Erb M, Leube DT, Jessen F, Kircher TT, et al. Mild cognitive impairment (MCI) and actual retrieval performance affect cerebral activation in the elderly. Neurobiology of Aging. 2007;28(3):404–13.
Article
PubMed
Google Scholar
Clément F, Belleville S, Mellah S. Functional neuroanatomy of the encoding and retrieval processes of verbal episodic memory in MCI. Cortex. 2010;46(8):1005–15.
Article
PubMed
Google Scholar
Jin M, Pelak VS, Curran T, Nandy RR, Cordes D. A preliminary study of functional abnormalities in aMCI subjects during different episodic memory tasks. Magn Reson Imaging. 2012;30(4):459–70.
Article
PubMed
PubMed Central
Google Scholar
Clément F, Belleville S. Compensation and disease severity on the memory-related activations in mild cognitive impairment. Biol Psychiatry. 2010;68(10):894–902.
Article
PubMed
Google Scholar
Machulda MM, Senjem ML, Weigand SD, Smith GE, Ivnik RJ, Boeve BF, et al. Functional magnetic resonance imaging changes in amnestic and nonamnestic mild cognitive impairment during encoding and recognition tasks. J Int Neuropsychol Soc. 2009;15(3):372–82.
Article
PubMed
PubMed Central
Google Scholar
Giovanello KS, De Brigard F, Ford JH, Kaufer DI, Burke JR, Browndyke JN, et al. Event-related functional magnetic resonance imaging changes during relational retrieval in normal aging and amnestic mild cognitive impairment. J Int Neuropsychol Soc. 2012;18(5):886–97.
Article
PubMed
Google Scholar
Bayram E, Caldwell JZ, Banks SJ. Current understanding of magnetic resonance imaging biomarkers and memory in Alzheimer's disease. Alzheimers Dement. 2018;4:395–413.
Google Scholar
Jessen F, Block W, Träber F, Keller E, Flacke S, Papassotiropoulos A, et al. Proton MR spectroscopy detects a relative decrease of N-acetylaspartate in the medial temporal lobe of patients with AD. Neurology. 2000;55(5):684–8.
Article
CAS
PubMed
Google Scholar
Kantarci K, Smith GE, Ivnik RJ, Petersen RC, Boeve BF, Knopman DS, et al. 1 H magnetic resonance spectroscopy, cognitive function, and apolipoprotein E genotype in normal aging, mild cognitive impairment and Alzheimer's disease. J Int Neuropsychol Soc. 2002;8(7):934–42.
Article
CAS
PubMed
PubMed Central
Google Scholar
Pfefferbaum A, Adalsteinsson E, Spielman D, Sullivan EV, Lim KO. In vivo brain concentrations of N-acetyl compounds, creatine, and choline in Alzheimer disease. Arch General Psychiatry. 1999;56(2):185–92.
Article
CAS
Google Scholar
Watanabe T, Shiino A, Akiguchi I. Hippocampal metabolites and memory performances in patients with amnestic mild cognitive impairment and Alzheimer’s disease. Neurobiol Learn Mem. 2012;97(3):289–93.
Article
CAS
PubMed
Google Scholar