Articles

Surgical outcome of primary intradural spinal arachnoid cysts: a series of 10 cases

Primary intradural spinal arachnoid cysts are rare pathologies of uncertain etiology and variable presentation from no symptoms to myelopathy or radiculopathy according to cord or root compression. MRI with di...

Authors: Essam Abdelhameed and Ahmed Ali Morsy

Role of some inflammatory biomarkers in prediction of short-term outcome in acute ischemic stroke

Several factors affect acute ischemic stroke (AIS) outcomes.

Authors: Yosria Abd Al Hameed AlTaweel, Rania Sanad Nageeb, Pakinam Mahmoud Metwally and Ahmed Elsayed Badawy

Serum level of brain-derived neurotrophic factor in patients with relapsing–remitting multiple sclerosis: a potential biomarker for disease activity

Brain-derived neurotrophic factor (BDNF) is secreted by immune cells in response to neuroimmune and inflammatory cascades as an act to prevent axonal and neuronal damage after various pathological insults. The...

Authors: Mohammed I. Oraby, Hatem A. El Masry, Sanaa S. Abd El Shafy and Esraa M. Abdul Galil

Frequency of peri-ictal apnea and cardiac arrhythmias in epileptic seizures

Available data from witnessed and monitored sudden unexpected death in epilepsy (SUDEP) cases postulate that ictal central apnea (ICA) and ictal arrhythmias are the main causes of SUDEP. ICA is a frequent semi...

Authors: Rady Yousif, M. Ossama Abdulghani, A. Gaber, Naglaa El Khayat, Y. A. Abo Elnaga and Mona Mokhtar Wahid El Din

Clinical predictors to cognitive impairment in multiple sclerosis patients

Cognitive dysfunction is increasingly recognized in multiple sclerosis, even in the early phase of the disease. Multiple sclerosis patients with even mild cognitive deficits may experience greater difficulties...

Authors: Haidy Elshebawy, Ebtesam Mohamed Fahmy, Nervana Mohamed Elfayoumy, Ahmed Mohamed Abdelalim and Rania Shehata Ismail

Assessment of cerebral hemodynamics in multiple sclerosis patients

Multiple sclerosis (MS) is the most common demyelinating disease of the central nervous system. Autonomic dysfunction is present in a wide range of patients (15–80%) that might present with abnormalities in th...

Authors: Nouran M. Salah, Ahmed M. Elsadek, Lobna M. ELnabil, Ayman M. Nassef, Azza A. Abdelaziz and Mohamed A. Abdel Hafeez

MicroRNAs in central nervous system disorders: current advances in pathogenesis and treatment

MicroRNAs (miRNAs) are a class of short, non-coding, regulatory RNA molecules that function as post transcriptional regulators of gene expression. Altered expression of multiple miRNAs was found to be extensiv...

Authors: Mona Hussein and Rehab Magdy

Sequential approach of internal maxillary-to-middle cerebral artery bypass and endovascular occlusion for giant middle cerebral artery aneurysm: a case report

The combined approach to complex brain МСА aneurysm seems to be generally considered viable. Although it is fairly common, the combinations of modalities, which are suggested in different case reports, vary si...

Authors: Andrey Vladimirovich Sergeev, Alexander Viktorovich Savello, Vladislav Urievich Cherebillo, Aigazi Islamovich Kiskaev and Fatima Chemurzieva

Association of epileptiform brain activity and specific language impairment (SLI) in preschool children

Epileptiform activities can cause transient or permanent deficits that affect the children during development and may be accompanied by neurodevelopmental disorders like specific language impairment.

Authors: Ahmed Esmael, Sara Elsherbeny and Mohammed Abbas

High neutrophil-to-lymphocyte ratio predicts early neurological deterioration in spontaneous intracerebral hemorrhage patients

Intracerebral hemorrhage (ICH) is caused by bleeding, primarily into parenchymal brain tissue, and accounts for 9 to 27% of all strokes worldwide. Higher neutrophils, lower lymphocytes, and higher neutrophil-t...

Authors: Wafaa S. Mohamed, Amr E. Kamel, Ahmed H. Abdelwahab and Mohamed E. Mahdy

Depression and COVID-19 patients with chronic pain: practical considerations

Authors: A. Alcántara Montero, S. R. Pacheco de Vasconcelos and F. Peñato Tarifa

Correlation of cortical lesions of multiple sclerosis at double inversion recovery with cognition screening scores

Multiple sclerosis is a chronic inflammatory disease affecting both white and gray matters of the central nervous system. It has been approved that the degree of gray matter involvement is closely associated w...

Authors: Sally Mohamed Shaaban, Azza Elmongui Elmongui, Ahmed Abdel Khalek Abdel Razek and Tamer Mohamed Belal

Hydrocephalus with lateral ventricular lesions: case series and review of literature

Lateral ventricular lesions associated with hydrocephalus are considered a challenge to neurosurgeons. Hydrocephalus after surgery of such lesions and its pathogenesis and how to deal with it is a big question...

Authors: Ahmed Mohamed Ahmed Alselisly, Ahmed Hamdy Ashry and Ayman Tarek Mahmoud

Validity of neuron-specific enolase as a prognostic tool in acute ischemic stroke in adults at Suez Canal University Hospital

Biological markers of acute nerve cell damage can assist in the outcome of acute ischemic stroke, such as neuron-specific enolase (NSE) that have been tested for association with initial severity of stroke, ex...

Authors: Mohammed H. Shash, Reda Abdelrazek, Nashwa M. Abdelgeleel, Rasha M. Ahmed and Adel H. El-baih

Neurologic manifestations of COVID-19 infection in Asia: a systematic review

COVID-19 infection can show various manifestation, including neurologic manifestations, such as anosmia, ageusia, or dysgeusia, and causes the neurologic disorder such as stroke, Guillain-Barre syndrome, encephal...

Authors: I. Putu Eka Widyadharma, Alvin Hendellyn, A. A. A. Putri Laksmi Dewi, I. Made Oka Adnyana, D. P. G. Purwa Samatra and Desak Ketut Indrasari Utami

Prevalence of antinuclear antibody in patients with multiple sclerosis: a case-control study

Antinuclear antibody (ANA) is a common test for excluding alternative diagnoses. However, the significance of ANA testing in patients with multiple sclerosis (MS) remains unclear.

Authors: Hind Alnajashi and Foziah Alshamrani

Migraine prevalence, clinical characteristics, and health care-seeking practice in a sample of medical students in Egypt

Migraine is a common disabling primary headache disorder with significant personal and socio-economic impacts. Medical students usually have multiple triggers for migraine, particularly stress and irregular sl...

Authors: Mohammed I. Oraby, Rasha H. Soliman, Mustafa A. Mahmoud, Eman Elfar and Noha A. Abd ElMonem

Comparison of knowledge, attitude, socioeconomic burden, and mental health disorders of COVID-19 pandemic between general population and health care workers in Egypt

The global devastating effect of COVID-19 has caused anxiety and fear to variable extent among the public. We aimed to evaluate the knowledge, attitude, socioeconomic burden, and the mental health problems reg...

Authors: Gellan K. Ahmed, Haidi Karam-Allah Ramadan, Samah Mohammed Refay and Mohamed A. Khashbah

Right to left shunting detection by contrast-enhanced transcranial color-coded duplex among patients with cryptogenic stroke

Contrast-enhanced transcranial duplex (c-TCD) might be more sensitive than transesophageal echo (TEE) for detection of right to left shunting (RLS), which misses some cases with substantial RLS and might be va...

Authors: Samia Ashour Mohamed, Mohamed Ayman Saleh, Hala Mahmoud ELKhawas, Eman Saleh ElHadidi, Ahmed ElSadek and Noha Lotfy Soliman

Post-stroke dysphagia: frequency, risk factors, and topographic representation: hospital-based study

The frequency of dysphagia varies considerably across literature. Post-stroke dysphagia is a common cause of increased morbidity and length of hospitalization. This study aimed to estimate the frequency, risk ...

Authors: Eman M. Khedr, Mohamed A. Abbass, Radwa K. Soliman, Ahmed F. Zaki and Ayman Gamea

Could SARS-CoV-2 herald a surge of multiple sclerosis?

During the current COVID-19 pandemic, many queries are raised regarding its nature, outcome, and sequelae. This letter raises the concern of potential impact on increasing the incidence of multiple sclerosis w...

Authors: Nevin Mohieldin Shalaby and Hatem Samir Shehata

The efficacy of repetitive transcranial magnetic stimulation in treating patients with chronic daily headache

Headache is the most common pain disorder, affecting around 66% of the global population. This study aimed to investigate the efficacy of high-frequency

Authors: Ann Ali AbdElkader, Ebtesam Mohammed Fahmy, Ayat Allah Farouk Ahmad, Amira A. Labib, Leqaa Ali El-Mekkawy and Shaimaa shaheen Mohammed Abd El Razek

Elevated factor VIII levels and arterial stroke: a review of literature with a case report

Cerebral arterial thromboses or ischemic strokes may be caused by cumulative or independent effects of a variety of risk factors. High factor VIII level is one of those important but less known risk factors fo...

Authors: Dinesh Khandelwal, Vaibhav Mathur, Arvind Vyas, Chandani Shah, Chandrajeet Singh Ranawat and Parth Patel

Clinical differentiation of psychogenic non-epileptic seizure: a practical diagnostic approach

Psychogenic non-epileptic seizure (PNES) has long been the counterpart of epileptic seizure (ES). Despite ample of evidence differentiating the two, PNES mistakenly diagnosed as ES was still common, resulting ...

Authors: I. Putu Eka Widyadharma, Andreas Soejitno, D. P. G. Purwa Samatra and Anna M. G. Sinardja

Spheno-orbital meningiomas: surgical techniques and results

Spheno-orbital meningiomas are characterized by bone invasion with extensive hyperostosis and possible encroachment into the orbit, infra-temporal fossa, and/or the cavernous sinus that render total surgical e...

Authors: Mohamed Abdelrahman Elborady and Wael Mohamed Nazim

Prospective study of thyroid functions in multiple sclerosis patients treated with interferon beta in Alexandria University MS clinic

The incidence of thyroid dysfunction in multiple sclerosis (MS) patients on interferon (as a disease-modifying line) has been reported in many studies performed on patients already on interferon therapy. Our s...

Authors: Farouk Talaat and Hany Eldeeb

Characteristics of headache disorders, according to ICHD-III in an outpatient headache clinic in Sohag Governorate, Egypt

Headache disorders are rated among the ten most disabling conditions around the world. The primary headache disorders are more common that of secondary headache. The third edition of the International Classifi...

Authors: Al-Amir Bassiouny Mohamed

Post-stroke dementia: frequency, predictors, and health impact

Cognitive impairment is an important aspect for stroke survivors. Little data are available about the frequency and risk factors of post-stroke dementia in Egypt.

Authors: Bastawy Al Fawal, Ahmed Ibrahim and Mohamed Abd Elhamed

Predictors of the functional outcome after thrombolysis in an Egyptian patients’ sample

About 6.2 million individuals worldwide and approximately 200 Egyptians/100,000 citizens have cerebrovascular stroke annually, and only less than 1% of stroke patients received intravenous (IV) thrombolysis in...

Authors: H. M. Eldeeb, D. H. Elsalamawy, A. M. Elabd and H. S. Abdelraheem

Ischemia-modified albumin and fibulin-5 as diagnostic and prognostic markers for acute cerebrovascular disease

Fibulin-5 and ischemia-modified albumin (IMA) levels increase in acute phase of cerebrovascular diseases, yet data regarding their levels in various stroke subtypes and correlation with severity and prognosis ...

Authors: Hosna S. Elshony, Mohammed A. Okda and Rasha A. El-Kabany

The efficacy of ultrasound-guided multifidus cervicis plane block versus greater occipital nerve block for cervicogenic headache

Traditionally, non-invasive and invasive techniques were used for the treatment of cervicogenic headache (CH). Greater occipital nerve block is the most frequent peripheral nerve block invasive technique used ...

Authors: Zenat Eldadamony Mohamed, Carmen Ali Zarad, Mohamed E. Flifel and Ali A. Abou Elmaaty

The value of cervical MRI in surgical lumbar canal stenosis patients

The prevalence of cervical canal stenosis alone is estimated to be present in 4.9% of the adult population. Co-existence of dual pathology may complicate clinical presentation and necessitates a wise and indiv...

Authors: Omar Youssef Abdalla, Hieder Al-Shami, Heba Medhat Maghraby and Abdelrhman Enayet

Topiramate-induced ocular side effects in Egyptian patients, idiosyncratic versus dose-dependent effect, a prospective study

To test the nature of the ocular side effects induced by topiramate (TPM) whether dose dependent or idiosyncratic, and to test various predictors that might influence the occurrence of those side effects.

Authors: Mohamed N. Thabit and Mahmoud Mohamed Farouk

Anosmia and COVID-19: perspectives on its association and the pathophysiological mechanisms involved

With the spread of SARS-CoV-2, contingency measures and plans to facilitate the screening of infected patients are needed. Changes in olfaction have been cited as symptoms of the disease, and it is important t...

Authors: Paulo Roberto da Silva Júnior, André Luis Oliveira Ramos Gomes, Lucas Eugênio Araújo Coelho, Mariana Almeida Morais, Pedro Vinícius Furtado Carneiro de Almeida, Wagner José Raia Neri, Guilherme Veras Mascena and Adriana Amorim de Farias Leal

Natalizumab-associated progressive multifocal leukoencephalopathy (PML) in multiple sclerosis (MS): “a case report from Ireland with review of literature, clinical pitfalls and future direction”

Progressive multifocal leukoencephalopathy (PML) is one of the most serious treatment-related complications that is encountered in patients with multiple sclerosis (MS). PML is a serious complication of MS tre...

Authors: Salman Mansoor, Gerard Mullane, Mohammad Hijaz Adenan, Siobhan Kelly, Aine Water, Grainne McPartland and Kevin Murphy

Corrected QT interval and QT dispersion in temporal lobe epilepsy

Cardiac arrhythmias are expected among patients with epilepsy due to the effect of anti-epileptic drugs. Temporal lobe epilepsy also causes autonomic seizures that may affect heart rhythm. Prolongation of the ...

Authors: Maram Samy Nasef, Ahmed Abdelmonem Gaber, Yousry Aboelnaga Abdelhamid, Islam Bastawy, Salem Taha Abdelhady and Mona Mokhtar Wahid el din

Repetitive transcranial magnetic stimulation as a prophylactic treatment in migraine

Clinical applications of transcranial magnetic stimulation (TMS) have shown promising results in the treatment of headache disorders, with migraine being one of the most encountered.

Authors: Azza B. Hammad, Rasha E. Elsharkawy and Ghada S. Abdel Azim

Troponin-I elevation predicts outcome after thrombolysis in ischemic stroke patients

Prognostic significance of troponin-I (T-I) elevation for poor short-term outcome in thrombolyzed ischemic stroke patients remains uncertain.

Authors: Rania S. Nageeb, Alaa A. Omran and Wafaa S. Mohamed

An unusual presentation of posterior reversible encephalopathy syndrome—a case report

Acute neurological emergencies in pregnant and postpartum women presenting as headache, visual disturbances, seizures, and elevated blood pressure are usually attributed to preeclampsia and eclampsia. However ...

Authors: K. Soundarya Rajeshwari, Vishaka Agarwal, S. Satish and K. T. Jayakumar

Effect of cycling exercise on motor excitability and gait abnormalities in stroke patients

The concepts of brain excitability are still re-wiring in response to changes in environment. Ambulation is often limited in stroke patients.

Authors: Mohamed S. El-Tamawy, Moshera H. Darwish, Mye A. Basheer, Abdelazim M. Reda, Mahmoud Elzanaty and Heba A. Khalifa

Short-term outcome in ischemic stroke patients after thrombolytic therapy

Stroke represents the second leading cause of death in the world after myocardial infarction. Intravenous (IV) thrombolysis with recombinant tissue plasminogen activator (alteplase, rt-PA) is the only pharmaco...

Authors: Wafaa S. Mohamed, Adel S. Abdel Ghaffar, Ahmed E. Abdel Gawad and Emad L. Agban

Pain as clinical manifestations of COVID-19 infection and its management in the pandemic era: a literature review

Coronavirus disease 2019 (COVID-19) is a current global pandemic. The case number has increased since December 31, 2019. It has been reported that COVID-19 patients have been giving pain complaints, one of whi...

Authors: I. Putu Eka Widyadharma, Ni Nyoman Shinta Prasista Sari, Kadek Enny Pradnyaswari, Kadek Tresna Yuwana, I. Putu Gede Danika Adikarya, Clarissa Tertia, I. A. Sri Wijayanti, I. A. Sri Indrayani and Desak Ketut Indrasari Utami

A case series of ischemic stroke with coronavirus disease 2019 in two Egyptian centers

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel virus that has been reported to have various neurological manifestations. Cerebrovascular disorders have been encountered as a coronaviru...

Authors: Nevine El Nahas, Tamer Roushdy, Eman Hamid, Sherien Farag, Hossam Shokri, Mai Fathy, Eman Abushady, Ahmed Hazzou and Hany Aref

Evaluation of cerebrovascular hemodynamics in patients with idiopathic intracranial hypertension using transcranial Doppler

Idiopathic intracranial hypertension (IIH) is a disorder of increased intracranial pressure without a clear cause and can have serious visual effects. Previous research work suggests that transcranial Doppler ...

Authors: Mahmoud M. Allam, Hatem A. Almasry, Sandra M. Ahmed, Youssuf G. Taha and Mohammed I. Oraby

Association between microstructural white matter abnormalities and cognitive functioning in patients with type 2 diabetes mellitus: a diffusion tensor imaging study

Diffusion tensor imaging (DTI) technique is important for exploring more sensitive imaging-based biomarkers in prevention and early treatment of cognitive dysfunction induced by type 2 diabetes mellitus (DM).

Authors: Ahmed Osama, Tarek Hassan Khalil, Mohamed Negm, Reda AbdEl-Razek and Hend AbouElhamd

Motor disability in patients with multiple sclerosis: transcranial magnetic stimulation study

Transcranial magnetic stimulation (TMS) is a non-invasive procedure used in a small targeted region of the brain via electromagnetic induction and used diagnostically to measure the connection between the cent...

Authors: Anssam Bassem Mohy, Aqeel Kareem Hatem, Hussein Ghani Kadoori and Farqad Bader Hamdan

Depression and anxiety among patients with Parkinson’s disease: frequency, risk factors, and impact on quality of life

Depression and anxiety are non-motor symptoms of Parkinson’s disease (PD) that are often overlooked and underrated. This study aimed to highlight the frequency and risk factors of depression and anxiety among ...

Authors: Eman M. Khedr, Ahmed A. Abdelrahman, Yasser Elserogy, Ahmed Fathi Zaki and Ayman Gamea

Apolipoproteins A1 and B and their ratio in acute ischemic stroke patients with intracranial and extracranial arterial stenosis: an Egyptian study

Apolipoprotein A1 and B and their ratio are considered a better biomarker for cardiovascular diseases than a lipid profile, but this previous finding is not proved to cerebrovascular ischemic diseases. The aim...

Authors: Ebtesam Mohammed Fahmy, Mohammed Ahmed El Sayed El Awady, Sahar Abdel-Atty Sharaf, Nora Mahmoud Selim, Hazem El Sawy Abdo and Shaimaa Shaheen Mohammed

Value of vessel wall magnetic resonance imaging in the diagnosis of cerebrovascular diseases

Intracranial vessel wall imaging can detect non-stenotic lesions with further characterization of stenotic lesions that have already been detected with common angiographic methods. Magnetic resonance imaging (...

Authors: Sherien Farag, Hany Zaki El-Dien, Yasser Abdelazeem, Mohammed Khaled Elewa, Khaled Abdelmaksoud and Ahmed ElSadek

Atypical benzodiazepine misuse and withdrawal in patient with epilepsy: a case report

Benzodiazepines (BDZ) are a class of psychoactive drugs that have been widely used for the treatment of many medical conditions. In this paper, a case of an atypical pattern of diazepam dependence in a patient...

Authors: Natalia Piskorska and Andrzej Silczuk