Table 4 Comparison between monotherapy and polytherapy
From: Genetic generalized epilepsy: factors associated with drug resistance polytherapy
Monotherapy | Polytherapy | P value | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Mean | SD | Median | Minimum | Maximum | Mean | SD | Median | Minimum | Maximum | ||
Age at onset | 13.87 | 5.98 | 14.00 | 2.00 | 50.00 | 12.71 | 5.49 | 12.00 | 1.00 | 30.00 | 0.013 |
Age of diagnosis | 14.77 | 6.45 | 14.00 | 2.00 | 50.00 | 13.27 | 6.67 | 13.00 | 1.00 | 60.00 | 0.001 |
Interval between onset and diagnosis | 0.89 | 2.25 | 0.00 | 0.00 | 16.00 | 0.60 | 3.14 | 0.00 | 0.00 | 35.00 | < 0.001 |
Age of first remission (R1) | 15.46 | 6.69 | 15.00 | 2.00 | 52.00 | 16.90 | 9.36 | 16.00 | 1.00 | 62.00 | 0.151 |
Age of maximum remission (Rmax) | 18.17 | 8.39 | 17.00 | 2.00 | 52.00 | 20.90 | 11.51 | 20.00 | 1.00 | 62.00 | 0.011 |
Seizure frequency (GTC) before treatment (number/ year) | 1.42 | 2.16 | 1.00 | 0.00 | 24.00 | 3.21 | 5.62 | 1.00 | 0.00 | 36.00 | < 0.001 |
Maximum remission period | 6.69 | 3.91 | 5.00 | 2.00 | 30.00 | 4.45 | 3.43 | 4.00 | 0.00 | 17.00 | < 0.001 |
VPA_dose_R1 | 635.56 | 353.91 | 600.00 | 250 | 1500.00 | 912.74 | 382.86 | 1000.00 | 250 | 2000.00 | < 0.001 |