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Pediatric vs. adult stroke: comparative study in a tertiary referral hospital, Cairo, Egypt



Even though stroke is rare in children, it is associated with serious or life-threatening consequences. Despite its rarity, the occurrence of stroke in children has age-related differences in risk factors, etiopathogenesis, and clinical presentations. Unlike adults, who have arteriosclerosis as the major cause of stroke, risk factors for pediatric strokes are multiple, including cardiac disorders, infection, prothrombotic disorders, moyamoya disease, moyamoya syndrome, and others. The goal of the current study was to compare the characteristics, clinical features, etiology, subtypes, and workup of pediatric and adult strokes.


This was a hospital-based observational study conducted on 222 participants. All patients underwent a full clinical and neurological examination, full laboratory study, cardiac evaluation, and neuroimaging; CT scan, MRI, MRA, MRV, carotid duplex, and transcranial Doppler (TCD). Ischemic stroke (IS) etiology was classified according to the Trial of Org 10172 in Acute Stroke Treatment (TOAST) criteria, the "proposed classification for subtypes of arterial ischemic stroke in children," and the Oxfordshire Community Stroke Project (OCSP). Stroke severity was determined by the National Institutes of Health Stroke Scale (NIHSS) and PedNIHSS on admission.


The proportion of pediatric ischemic strokes in the current study was 63.4 percent, while hemorrhagic strokes were 36.5%. The majority of the adult patients had ischemic strokes (84.1%), while hemorrhagic strokes were noted in 15.8% of the patients. According to the original TOAST classification, in the current study, the etiology of pediatric IS was other determined causes in 63.6%, undetermined etiology in 27.2%, and cardioembolic in 9.0%. For the adult group, the major stroke subtypes were large artery disease, small vessel disease, cardioembolic, other determined causes, and undetermined etiology at 49.6%, 28.6%, 6.9%, 0.6%, and 12.5%, respectively.


There is a greater etiological role for non-atherosclerotic arteriopathies, coagulopathies, and hematological disorders in pediatric stroke, while adults have more atherothrombotic causes. The co-existence of multiple risk factors in pediatric ischemic stroke is noticed. Thrombophilia evaluation is helpful in every case of childhood stroke. Children who have had a stroke should undergo vascular imaging as soon as possible. Imaging modalities include TCD and Doppler ultrasound, CT, MRI, MRA, and MRV, and cerebral angiography.


Stroke is the second leading cause of death worldwide, accounting for around 5.5 million fatalities per year. Stroke has a high mortality rate, but it also has a high morbidity rate, resulting in up to 50% of survivors being permanently impaired. Thus, stroke is a major public health problem with substantial economic and social ramifications. The public health burden of stroke is expected to rise in the coming decades as a result of population demographic shifts, particularly in developing countries [1]. Although stroke can occur at any age or stage in life, pediatric stroke is a rare condition. However, the high rate of morbidity and mortality in pediatric stroke is ascribed to significant delays in diagnosis, and this is because of a lack of awareness as well as its rarity. Pediatric strokes are exceedingly rare, with an incidence of 1.2 to 2.7 per 100,000 children aged 1 month to 18 years in developed countries [2]. However, it is a major source of persistent neurologic disabilities, such as hemiparesis, epilepsy, and cognitive dysfunction [3]. The proportion of patients with long-term neurologic deficit, and the impact on quality of life and the health care system could be significantly higher in children [4].

The clinical presentation of pediatric stroke is extremely various, depending on age, cause, affected vascular territory, and stroke subtype. Although, focal neurologic deficits are common presentation of ischemic stroke (IS) in children, diffuse manifestations such as seizures, headache, and altered mental status are also possible [5]. The diagnosis of stroke is particularly perplexing in children because of the high prevalence of stroke mimics (migraine, Todd’s paralysis, and psychogenic causes) as history and physical examination alone cannot reliably distinguish stroke and mimics [6]. However, seizures within the acute setting of childhood stroke are common and undiagnosed [7].

Children have a more diverse and larger number of etiological factors and risk factors for stroke that differ significantly from adults [8]. For childhood IS predisposing factors include vasculopathies, such as transient cerebral arteriopathy, arterial dissection, fibromuscular dysplasia, and Moya–Moya Disease [9]. In addition, prothrombotic disorders such as protein C and protein S deficiency, antithrombin III deficiency, factor V Leiden mutation. The acquired risk factors for pediatric thromboembolic stroke include iatrogenic causes, acute diseases (sepsis and dehydration), chronic diseases (malignancy, renal, cardiac, collagen and rheumatic diseases) and substance abuse, especially in teenage patients [10]. In addition, stroke subtypes, risk of recurrence, and choices of management differ between both groups. Almost 55% of pediatric strokes are ischemic vs. 80% in adults. In addition, although 20% of adult strokes are hemorrhagic, this stroke type accounts for approximately half of all childhood strokes [11].

With the onset of impairment during childhood and the effect on quality of life for the child and family, the physical and emotional costs are augmented [6]. Affected patient have time urgent, critical needs that present unique challenges to the neurologist, pediatrician, anesthetist, and interventional radiologists. Successful treatment requires rapid recognition and evaluation, imaging, and treatment [12].

This study was designed to determine the stroke subtypes, clinical presentation and the main pathophysiological mechanisms that lead to stroke in children in comparison to adults in tertiary referring hospital for better understanding of underlying mechanisms of stroke so as to improve the prospects for primary and secondary prevention in such cases.


This was a hospital-based observational study conducted on 222 participants. The patients were recruited consecutively from the stroke units of Ain Shams University Hospitals and Pediatrics department, Faculty of Medicine Ain Shams University during the period from July 2020 till to January 2022. This study was approved by the ethical committee of Ain Shams University and an informed consent was obtained from all participants and or their caregivers in the study. The diagnosis was made based on the clinical features in combination with brain imaging [13]. The inclusion criteria were patients admitted with the diagnosis of acute stroke within 48 h of onset of the symptoms. Group (A) included pediatric stroke patients whose ages ranged from 1 month to 18 years, and Group (B) included adult stroke patients whose ages above 18 years. Exclusion criteria were patients with perinatal stroke, patients who developed stroke in association with central nervous system infection, patients with traumatic cerebral hemorrhage, and patients with brain tumor, or other central nervous system diseases.

A full history was taken from all patients or their caregivers, the following variables were collected demographic data, vascular risk factors (known or discovered during hospitalization, such as smoking, hypertension, diabetes mellitus, dyslipidemia, obesity, atrial fibrillation [AF] and heart disease), drug intake, presence of patent foramen oval, usage of oral contraceptives, bleeding disorders (congenital or acquired), and any history of previous similar attacks were reported. Special stress on the onset of stroke, and its clinical presentation. All patients were subjected to full neurological and clinical examination to evaluate their neurological condition and to detect any evidence of systemic illness.

All patients were subjected to the stroke protocol and underwent MRI of the brain including diffusion weighted, T1, T2, Flair and gradient echo T2* weighted, together with an MRA of the brain. Brain CT angiography, and MRV were done in some cases. All imaging studies were evaluated by the same neuroradiologist.

All patients were subjected to an electrocardiogram, transthoracic echocardiography (TTE), and/or Transesophageal echocardiogram (TEE), carotid duplex and Transcranial Doppler (TCD).

Baseline investigations (performed upon admission) included a complete differential blood count, blood glucose, C-reactive protein, erythrocyte sedimentation rate (ESR), prothrombin time, activated thromboplastin time and metabolic screening, including liver function test, blood urea nitrogen, creatinine, serum electrolytes, serum iron level and triglycerides/cholesterol serum levels. For inherited thrombophilic disorders, genetic assay was conducted for factor V Leiden G1691A, factor II G20210A, and methyltetrahydrofolate reductase (MTHFR) C677T tests with homocysteine level. Antithrombin III, protein S, and protein C deficiencies were screened. Additional laboratory tests were considered (in some cases for the final diagnosis). Tests for connective tissue disorders, rheumatoid factor (RF), anti-cyclic citrullinated peptide, antinuclear antibodies, lupus anticoagulant (LA), anti-cardiolipins (ACLs), anti-double-stranded DNA, complement components (C3 and C4) were done in some cases. Cerebrospinal fluid analyses, and microbiologic examination by microscopy, culture, polymerase chain reaction (PCR), and d-dimer tests were done in some cases.

The stroke type was classified according to World Health Organization criteria (cerebral infarction, transient stroke, intracranial hemorrhage and cerebral venous thrombosis) [14].

Ischemic stroke etiology was classified according to the TOAST criteria [15]. Large-artery atherosclerosis (LAA) (embolus/thrombosis); clinical findings, and neuroimaging results consistent with LAA and other etiologies have been excluded; (1) Clinical and brain imaging findings of significant (> 50%) stenosis or occlusion of a major brain artery, presumably due to atherosclerosis. (2) A history of TIAs in the same vascular territory, a history of intermittent claudication, the presence of a carotid bruit or diminished pulses. (3) Cortical or cerebellar lesions and brain stem or subcortical hemispheric infarcts > 1.5 cm in diameter on CT or MRI [16].

Cardio-embolism; if there was, one major cardiac risk factor for embolism with no evidence of other stroke subtypes. Small-vessel occlusion; defined as clinical lacunar syndrome, with infarction less than 1.5 cm. Stroke of other determined etiology, if there was evidence of other stroke risk factor (hypercoagulable states or nonatherosclerotic vasculopathy) with the absence of other stroke subtypes features. Stroke of undetermined etiology; if there were more than one potential cause and no etiology found from the investigations [17]. Focal cerebral arteriopathy is a unilateral focal stenosis with irregularity of the large intracranial arteries of the anterior circulation (distal internal carotid artery and/or its proximal branches) [18]. Moyamoya disease is a unilateral or bilateral progressive cerebral arteriopathy with collaterals formation, with radiologic evidence of stenosis or vessel irregularity of large intracranial arteries (distal internal carotid artery, middle cerebral artery, anterior cerebral artery, posterior cerebral artery) supplying the territory of the infarct, and evidence of an excessive collateral network of vessels distal to the occluded arteries [5].

Stroke subtypes in children were categorized according to the TOAST criteria and the ‘‘proposed classification for subtypes of arterial ischemic stroke in children” [19].

Acute ischemic stroke (AIS) was classified according to the presenting clinical features, and the cerebral territory affected with the Oxfordshire Community Stroke Project (OCSP); Total anterior circulation syndrome (TACS), Partial anterior circulation syndrome (PACS), Posterior circulation syndrome (POCS), and lacunar syndrome (LACS) based on their maximum neurological defects [20]. Stroke severity was determined by National Institutes of Health Stroke Scale (NIHSS) and PedNIHSS on admission [21, 22].

Statistical analysis

Results were expressed as mean ± standard deviation or number (%). Comparison between categorical data [number (%)] was performed using Chi square test or Fisher exact test instead if cell count was less than five. Test of normality, Kolmogorov–Smirnov test, was performed to measure the distribution of data. Comparison between not normally distributed data (variables) in the two groups was performed using Mann Whitney test. Statistical Package for Social Sciences (SPSS) computer program (version 19 windows) was used for data analysis. p value ≤ 0.05 was considered significant.


This study included two groups: Group (A) pediatric stroke and group (B) adult stroke. Pediatric and adult patient identification and classification are shown in the flowchart in (Fig. 1).

Fig. 1
figure 1

Flowchart of (A) pediatric stroke group and (B) adult stroke group

The pediatric group consisted of 52 children, 31 males and 21 females; with median age of 6 years and 3 months; age range from 2 months to 18 years. Other demographic data for this together with risk factors and significant medical history are stated in (Table 1).

Table 1 Demographic, vascular risk factors, and comparisons between pediatric ischemic and hemorrhagic strokes

The adult group consisted of 170 patients, 108 were males (36.5%) and 62 were females (63.5%). The median age at the time of presentation was 64 years and 6 months, and the age range was 26–92 years. Other demographic data for this group together with risk factors and significant medical history are stated in (Table 2).

Table 2 Demographic and vascular risk factors of both types of stroke in an adult group

In comparison of the clinical presentations of IS in both pediatric and adult groups, diffuse manifestations, especially headache, vomiting, seizures, altered consciousness, and fever, were significantly common in pediatric IS patients, while focal manifestations, aphasia, dysarthria, neuro-ophthalmologic signs, facial palsy, hemiparesis, hemianesthesia, and ataxia/gait abnormality, were significantly higher in adult IS patients. Stroke severity in both pediatric and adult IS was assessed with the PedNIHSS and NIHSS scores and was similar (Table 3).

Table 3 Clinical presentations of ischemic stroke in both groups

Children with HS had more significant diffuse clinical manifestations, such as headaches, vomiting, and seizures. While the focal manifestations, especially dysarthria, facial palsy, hemiparesis, and hemianesthesia, were significantly common in adult HS patients. Stroke severity in both pediatric and adult HS was assessed with the PedNIHSS and NIHSS scores in the adult HS group with a low score in the pediatric group (Table 4).

Table 4 Clinical presentations of hemorrhagic stroke in both group

In this study, hypercoagulable disorders, either genetic or acquired, were rarely seen in adult IS, and although it was a major stroke risk factor in 10 patients (30.3%) of pediatric IS (Table 5).

Table 5 Role of thrombophilia in ischemic stroke in both groups

Large artery atherosclerosis was a common cause of adult stroke in this study. Twenty-one children and one adult were allocated to the “other determined etiology” category. Multiple probable stroke etiologies were identified in 8 children (24.2%) and 18 (12.5%) adults (Table 6).

Table 6 Ischemic stroke subtypes and etiology (TOAST) in both groups

According to the OCSP classification, approximately 37.5% of pediatric IS had PACS, 29.1% had TACS, and 25.0% had POCS, followed by (8.3%) having LACS (Table 7). Similarly, 32.1% of adult IS suffered from TACS, 25.5% from LACS, 23.5% from POCS, and 19.2% from PACS. There was a significant difference between both groups, as PACS was a common clinical subtype in pediatric IS, while LACS was the common subtype in adult IS.

Table 7 Clinico-radiological ischemic stroke subtypes in both groups (OCSP classification)

Etiologically, the causes of pediatric cerebral venous sinus thrombosis (CVST) were prothrombotic state (5/10), postinfectious (COVID) (1/10), hematological disease (1/10), vasculitis (1/10), congenital heart disease (1/10), and undefined disease (1/10). In contrast to the adult CVST group, postinfectious (2/6), hypercoagulable state (1/6), contraceptive pills (1/6), and undefined disease (2/6).

For the pediatric HS, the final etiological diagnosis was an AVM in 11 patients (57.8%), a cerebral aneurysm in 5 (26.3%), and a hematological etiology in one case and vasculitis in another case. In adult HS, hypertension (17 cases, 62.9%), cerebral aneurysm (5 cases, 18.5%), and cerebral amyloid angiopathy (2 cases, 7.2%) are the most common causes. Despite comprehensive investigations, undetermined etiology was reported in one case of children and six cases (22.2%) of adults (Table 8).

Table 8 Etiology of hemorrhagic stroke in both groups


The incidence of the two main subtypes of stroke (ischemic and hemorrhagic) is different in adults and children. According to the current study, in childhood, a slight predominance of the IS vs. HS was found at 63.4% and 36.5%, respectively, but in adults, 84.1% had an ischemic stroke and 15.8% had a hemorrhagic stroke. Similar results were reported by two different studies [23, 24], where 58.6% vs. 38.6% or 64% vs. 36% for pediatric stroke. However, in studies reporting strokes in children globally, both types of stroke are equally common [25]. In addition, Chiang and Cheng’s [26] results were closer to global reports; hemorrhagic stroke was 43.6%, ischemic stroke was 36.1%, and TIA was 5%. The differences in these studies are undoubtedly due to a diverse range of researches using different methodologies, study populations, and inclusion criteria. In addition, there is an inherent selection bias, because the bulk of these pediatric stroke researches were conducted at tertiary children's medical centers. However, the current results agreed with the worldwide incidence of adult ischemic stroke, subarachnoid hemorrhage, and intracerebral hemorrhage, 80–85%, 1–7%, and 7–27%, respectively [27, 28]. In addition, approximately 87% of strokes in the United States are ischemic, intracerebral hemorrhage in 10% and subarachnoid hemorrhage in 2% [29].

The male predominance observed in the present study was between boys (59.6%) and girls (40.3%) in the pediatric group, and 63.5% of the patients were males and 36.4% were females in the adult group. Similar findings have been previously reported in the Canadian Pediatric Ischemic Stroke Registry among patients with IS. There was a predominance of males (55%) compared with Canadian children [30]. In addition, Tan and colleagues discovered a male to female ratio of 1.9–1, which was consistent with many previous studies of ischemic stroke in Asia and elsewhere [31]. Hormonal factors may predispose males to early thrombotic stroke and can explain this gender predominance [32].

Children with stroke have remarkable differences in clinical presentation compared with adults; in the current study. Diffuse manifestations, especially headache, vomiting, seizures, altered consciousness, and fever, were significantly common in both subtypes of pediatric stroke, while focal manifestations, aphasia, dysarthria, neuro-ophthalmologic manifestations, facial palsy, hemiparesis, hemianesthesia, and ataxia/gait abnormality, were significantly higher in the adult group. Seizures at stroke onset are more common in children. Many studies have reported that 15–25% of children, particularly those under the age of six, present with seizures [2, 5, 33]. The enhanced excitability of the immature brain might favor seizure propagation in the context of acute stroke. In addition, the immature central nervous system may not demonstrate focal signs, and hemiparesis may not be apparent until a child is older than 6 months of age [34]. The occurrence of some presenting features, such as speech disturbance and headache, might vary with age because of age-related developmental changes. Headache at presentation was associated with older ages as it is largely self-reported relying on the development of adequate communication skills.

The leading risk factor for pediatric IS in the present study was vascular disorders, followed by hematological and prothrombotic disorders. Similarly, according to a study of 156 cases of IS by Jeong et al. (2015), the most common risk factors were arteriopathy in 83 cases, cardiac disease in 23 cases, prothrombotic conditions in 14 cases, and hematologic disease in 6 cases [35]. In addition, during the global COVID-19 pandemic, there were several reported case scenarios of IS occurring in children, as stated in our results, who either suffered acute respiratory distress syndrome caused by SARS-CoV-2 or who presented with IS and other symptoms as part of the pediatric multisystem inflammatory response in children associated with COVID-19 [36]. This might be explained by an uncontrolled inflammatory response and a cytokine storm following infection with SARS-CoV-2 [37]. For the adult group, the greatest risk factor in the current study was hypertension, followed by diabetes mellitus and dyslipidemia. This data agrees with many Egyptian studies, showing similar results as ours [38,39,40].

It has been widely recognized that stroke etiology differs between children and adults [19]. The main findings of the current study are that the subtypes of ischemic stroke are distinct in children and adults. According to the modified version of the TOAST classification, the first three subtypes (large artery atherosclerosis, cardioembolic, and small vessel disease) accounted for the majority of adult strokes (85.3%). In contrast, only 9% of children were accounted for within these three subtypes. The high prevalence of diffuse atherosclerosis, extracranial/intracranial stenosis and occlusion in this study may explain the high percentage of LAA in Egyptian patients compared to other studies. It is also well recognized that the prevalence of asymptomatic internal carotid artery stenosis (ICAS) was 13.1%, which is relatively high in Egypt [38]. In China, population-based studies using TCD have shown asymptomatic ICAS to be present in about 6–7% of healthy adults [41]. In Western countries, studies have shown asymptomatic ICAS in approximately 9% of the Spanish population [42]. In addition, El-Zayat et al. (2020) found that intracranial significant stenosis is more prevalent than extracranial in 61 acute ischemic stroke Egyptian patients [43]. Lately, Khedr et al. (2021) detected extracranial carotid atherosclerotic changes in 119 patients (64.3%) out of 185 Egyptian patients with acute cerebrovascular stroke [40]. These frequencies were higher than studies population in Pakistan, India and Iran [44,45,46].

In Egypt, there is a higher prevalence of DM (75.4%) than in Pakistan (37%), Asians (37%), Hispanics (50%), Caucasians (28%), and African Americans (31%). Similarly, there was a slightly higher prevalence rate of dyslipidemia (68.4%) in the Egyptian population, much higher than the same ethnic groups [47, 48]. These findings highlights underscore the importance of early risk factor detection and primary prevention, given the premature onset of cerebrovascular complications.

The majority of children were classified within the “other determined etiology” subtype vs. only one adult patient. Etiology was undetermined in 12.5% of adult cases, compared with 27.2% of children cases. Previous studies comparing stroke etiology in children and adults found more strokes due to undetermined causes in children than in adults, although with differing percentages. Other causes of stroke were detected in 49% of children and 44% of young adults by Williams and colleagues [49], whereas Wraige et al. [19] reported other causes of stroke in up to 80% of children and only 16% of young adults. In addition, Bigi and colleagues [50] found that 52% of children had strokes due to “other determined causes” according to the original TOAST classification, compared to 29% of adults.

In the current study, one or more prothrombotic states have been identified in 48.4% of children presenting with IS and 50% of children with CVST. In agreement with these data, Barnes and Deveber identified prothrombotic abnormalities in 20–50% of children presenting with AIS and 33–99% of children with CVST [51].

Infarcts in children, such as in adults, are most typically found in the anterior circulation. In the current study, according to the OCSP classification, PACS was the most common clinical subtype in pediatric IS (37.5%), while TACS was the most common subtype in adult IS (32.1%). Simonetti and colleagues detected stroke location in 2,768 pediatric AIS cases; 507 (18%) were located in the posterior circulation, 1931 (70%) in the anterior circulation, and 330 (12%) involved both. PCAIS is less common than ACAIS in the pediatric population. Although, children with PCAIS have lower stroke symptom severity at presentation, but they may have an increased stroke recurrence risk, than those with ACAIS [52]. These results highlight the importance of detailed clinical–radiological evaluation; MRI, MRA, MRV, duplex, and TCD of pediatric stroke patients.

Unlike adults who tend to have more cases of primary hypertensive ICH, children tend to suffer from secondary ICH due to vascular malformations or coagulopathy. For the pediatric HS in the current study, the most common etiological diagnosis was an AVM and cerebral aneurysm. However, for adult HS, hypertension was the most common cause, followed by cerebral aneurysm and cerebral amyloid angiopathy. In agreement with these findings, Beslow and colleagues detected that the causes of 22 children were arteriovenous malformation (40%), cavernous angioma (18%), aneurysm (14%), coagulopathy (14%), and others (18%). Acute pediatric hemorrhagic stroke management should include MRA whenever the patient is stable. In addition, unless an alternative cause is identified (as hemophilia), all pediatric patients with hemorrhagic stroke should ultimately have DSA before the hemorrhage is considered idiopathic [53].

Up to 90% of strokes could be avoided if vascular risk factors were controlled [29]. Identifying the cause of the first stroke, whether arterial occlusion or a transient ischemic episode, and developing multidisciplinary techniques to reduce those causes are critical steps in preventing future stroke risk factors. In addition, childhood stroke is well understood to be multifactorial, and atherosclerosis, the most common cause of IS in adults, is extremely rare in children. Thus, a comprehensive diagnostic evaluation is critical for prompt diagnosis and treatment to reduce the risk of brain damage and disability in children following a stroke.

This study had some probable limitations. The number in the pediatric group was relatively small due to the rarity of pediatric stroke. Assessing stroke severity is more difficult in children than in adults, and therefore, comparisons between children and adults might be limited to patients with extremes on the scale. Finally, because TEE was not performed on children, cardioembolic might be underdiagnosed in the pediatric group. Nevertheless, the major strengths of this study were its prospective study design with standardized patient assessment and stroke classification. Moreover, the current study; to our knowledge, was the first to identify stroke risk factors among the Egyptian pediatric population in a tertiary care referral center in Greater Cairo.


When dealing with pediatric strokes, physicians should keep in mind a few key differences from adults that can help with diagnosis and treatment: (1) the occurrence of unusual pediatric presentations; diffuse manifestations (only headache, seizure, or absence of obvious clinical symptoms). (2) For pediatric stroke, a more prominent etiological role for non-atherosclerotic arteriopathies, hematological disorders, and coagulopathies was detected, while adults have more atherothrombotic causes. (3) Multiple risk factors coexist in pediatric ischemic stroke. (4) Nontraumatic, spontaneous ICH, IVH, and SAH in childhood are caused by structural lesions in up to 85% of cases. (5) A thrombophilia evaluation is helpful in every case of pediatric stroke. (6) Children who have had a stroke should undergo neurovascular imaging as soon as possible. (7) Vascular imaging with MRA, can help to identify AVMs or cavernomas that may be the cause of cerebral hemorrhage. Conventional catheter-based angiography, though invasive, should be considered when no other explanation for the hemorrhage has been identified. (8) A decision-making process should be carried out case by case by a multi-specialist group, including the neurologist, neuropediatrician, and neuroradiologist.

Availability of data and materials

The data sets generated and analyzed during the current study are not publicly available due to institutional limitations, yet they are available from the corresponding author on reasonable request.



Acute ischemic stroke


Ischemic stroke


Trial of ORG 10172 in Acute Stroke Treatment


National Institutes of Health Stroke Scale




Transesophageal echocardiogram


Transthoracic echocardiography


Large-artery atherosclerosis


Methyltetrahydrofolate reductase


Coronavirus disease 2019


Rheumatoid factor


Antinuclear antibodies


Lupus anticoagulant




Arteriovenous malformation


Oxfordshire Community Stroke Project


Cerebral venous sinus thrombosis


Total anterior circulation syndrome


Partial anterior circulation syndrome


Lacunar syndrome


Posterior circulation syndrome


Hemophagocytic lymphohistiocytosis


Juvenile rheumatoid arthritis


Intracerebral hemorrhage


Hemorrhagic stroke


Anterior circulation ischemic stroke


Posterior circulation ischemic stroke


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NA and RA made substantial contributions to conception and design of the study; RA, MM and AA performed the acquisition of data; RA, HK, MN, RS, MM and AA participated in the analysis and interpretation of data; RA and KA have been involved in drafting the manuscript or revising it critically for important intellectual content; NA and KA has given final the approval of the version to be published. All authors agreed to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. All authors read and approved the final manuscript.

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Correspondence to Ramy Alloush.

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Alloush, R., Eldin, N.S., El-Khawas, H. et al. Pediatric vs. adult stroke: comparative study in a tertiary referral hospital, Cairo, Egypt. Egypt J Neurol Psychiatry Neurosurg 58, 82 (2022).

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