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The Egyptian Journal of Neurology, Psychiatry and Neurosurgery

Table 2 Progression of motor and physical activity over 6-month and 1-year follow-up

From: Baseline predictors of progression of Parkinson’s disease in a sample of Egyptian patients: clinical and biochemical

 

Baseline

6-month FU

1-year FU

RMANOVA

Baseline versus 6 months

6 months versus 1 year

Baseline versus 1 year

Mean (SD)

Mean (SD)

Mean (SD)

p

MDS-UPDRS total score OFF

81.75 (33.02)

86.50 (29.66)

105.86 (33.21)

 < 0.001*

0.009*

 < 0.001*

 < 0.001*

MDS-UPDRS-I

15.25 (7.29)

16.25 (6.24)

21.34 (6.01)

 < 0.001*

0.149

 < 0.001*

 < 0.001*

MDS-UPDRS-II

18.48 (10.19)

20.70 (8.62)

25.02 (9.14)

 < 0.001*

0.013*

 < 0.001*

 < 0.001*

MDS-UPDRS-III OFF

47.89 (19.82)

49.25 (18.95)

59.52 (21.65)

 < 0.001*

0.288

 < 0.001*

 < 0.001*

Tremor OFF

12.80 (7.47)

13.00 (7.56)

14.52 (8.03)

 < 0.001*

1

0.001*

0.002*

Bradykinesia OFF

15.93 (7.57)

16.57 (7.08)

20.93 (7.68)

 < 0.001*

0.356

 < 0.001*

 < 0.001*

Rigidity OFF

8.91 (4.15)

9.09 (3.68)

10.66 (3.95)

 < 0.001*

1

 < 0.001*

 < 0.001*

Axial OFFa

13.93(6.88)

14.70 (6.13)

18.23 (6.86)

 < 0.001*

0.014

 < 0.001*

 < 0.001*

PIGD OFFa

8.55 (5.72)

8.84 (5.26)

10.70 (5.54)

 < 0.001*

0.193

 < 0.001*

 < 0.001*

Motor complication total scorea

4.93 (4.48)

5.89 (4.18)

6.91 (4.23)

 < 0.001*

0.004

 < 0.001*

 < 0.001*

Hoehn and Yahr OFFa

2.53 (0.69)

2.63 (0.75)

3.00 (0.87)

 < 0.001*

0.024

 < 0.001*

 < 0.001*

Schwab and England ADL OFFa

76.14 (13.16)

71.14 (16.46)

63.64 (16.72)

 < 0.001*

 < 0.001

 < 0.001*

 < 0.001*

IPAQ

2058.77 (821.20)

1622.21 (779.69)

1186.73 (605.78)

 < 0.001*

 < 0.001*

 < 0.001*

 < 0.001*

  1. Bold values are significant
  2. MDS-UPDRS  Movement Disorder Society—Unified Parkinson’s Disease Rating Scale, PIGD  postural instability and gait disorder, ADL  activities of daily living, IPAQ  International Physical Activity Questionnaire, RMANOVA  repeated measures ANOVA
  3. aFriedman’s test was used and post hoc analysis was done by Wilcoxon tests with Bonferroni correction (p value is significant if < 0.017)
  4. *p value is significant if < 0.05
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