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Role of imaging in early diagnosis of acute ischemic stroke: a literature review
The Egyptian Journal of Neurology, Psychiatry and Neurosurgery volume 57, Article number: 175 (2021)
Stroke is a serious health condition that is responsible for more than 5% of total deaths. Near 20% of patients experiencing stroke die every year, resulting in the stroke being at the top of the list of preventable causes of death. Once an acute stroke is suspected, a golden hour of less than an hour is available to prevent the undesirable consequences. Since neuroimaging is mandatory in the diagnosis of stroke, the proper use of neuroimaging could help saving time and planning the right treatment for the patient. Some of the available imaging methods help us with rapid results, while others benefit us from a more accurate diagnosis. Hereby, we aim to provide a clinical review of the advantages and disadvantages of different available neuroimaging methods in approaching acute stroke to help clinicians choose the best method according to the settings.
Cerebrovascular diseases are serious health conditions that can affect the quality of life by leading to disabling consequences, such as dysarthria, paralysis, and amnesia [1, 2]. A stroke happens when the brain’s blood-supplying vessels are ruptured or blocked, usually along with thrombus formation, displaced embolism, stenosis in cerebral arteries, and hemorrhage in the brain parenchyma . These events can lead to a significant decrease in blood flow and oxygen to the brain, resulting in a stroke. Stroke is responsible for more than 10% of deaths worldwide , and one in five stroke patients die each year, putting stroke at the top of the list of preventable causes of death . Risk factors attributable to stroke are mainly the ones that are also common in other non-communicable diseases, such as diabetes, blood pressure, being obesity, smoking, and alcohol consumption; although, the prevalence of them may vary between different countries [6, 7].
In the management of acute stroke, a “golden time” of less than an hour is available from the onset of the symptoms, where making prudent diagnostic and therapeutic choices may result in fewer complications [8, 9]. Sense of weakness or numbness, visual loss or blurred vision, sensory disturbance, impaired consciousness, dizziness and loss of balance, dysphagia, headache, and speech problems are the most common findings in favor of stroke . Like other life-threatening emergencies, an accurate and rapid diagnosis is crucial. Delay in diagnosis could result in irreversible damages, since the brain tissue is lost for each minute delay. Several stroke assessment scales [such as Face Arm Speech Time (FAST), Cincinnati Prehospital Stroke Scale (CPSS), Los Angeles Prehospital Stroke Scale (LAPSS), and Melbourne Ambulance Stroke Scale (MASS)], and severity grading scores [such as Los Angeles Motor Scale (LAMS), Kurashiki Prehospital Stroke Scale (KPSS), and National Institutes of Health Stroke Scale (NIHSS)] have been developed, trying to facilitate the rapid diagnosis of stroke through different criteria. Simpler scales such as CPSS and FAST have been shown to have enough sensitivity for clinical purposes, while the more complex scales might have lower sensitivity and, therefore, miss more cases . Although some important clinical manifestations, such as face drooping, arm weakness, and speech difficulty, may suggest stroke in the initial assessment, the definitive diagnosis is primarily determined based on imaging . Therefore, an intelligent choice of imaging technique could result in an early, lifesaving diagnosis of acute stroke. This article aims to review the role of different imaging methods in the diagnosis of acute ischemic stroke and determine the advantages and disadvantages of each.
Etiology and pathophysiology of ischemic stroke
The main pathology of ischemic stroke is loss or abruption of blood circulation in specific parts of the brain, which could be due to the thrombotic or embolic occlusion . The thrombotic ischemic strokes are generally associated with atherosclerotic accidents and are classified based on the size of the involved vessels . Depending on the speed of the plaque rupture, it can be presented with sudden devastating damages or subtle pathologic changes that manifest slowly . In the latter situation, collateral circulation would partly compensate the circulation loss. The small-vessel ischemic stroke could occur as a consequence of systemic and chronic diseases, such as diabetes . Rarely, vasculitis can predispose the vessel walls to narrowing and obstruction . On the other hand, the embolic ischemic stroke is mainly caused by atrial fibrillation . In addition, several monogenic disorders (such as Ehlers–Danlos, Fabry’s disease, and Marfan syndrome) are associated with ischemic stroke [19, 20].
Regardless of the etiology, the abruption in blood circulation, a cascade of ischemia-related events initiate in both cellular level and macroscopic scale [13, 21]. In the first place, the energy supply by mitochondria gets interrupted—even in the absence of complete blood occlusion—leading to loss of function of the membranous proteins and an impaired gradient between intracellular and extracellular space, which eventually results in swelled neurons and glial cells (also referred to as cytotoxic edema) [22, 23]. Besides, the release of excitatory neurotransmitters adds extra stress in terms of energy supply by the cells, ectopic activation of destructive enzymes, such as lipases and proteases, destruction of vital organelles in neurons, and production of oxygen free radicals, eventually leading to necrotic death of the neurons in the core of the ischemic region, and triggering the cascade of apoptotic events in the peripheral neurons [24,25,26].
Importance of imaging in approach to stroke
For the following reasons, the suspicion of ischemic stroke should be followed by early neuroimaging:
Exclude the presence of hemorrhage
Apart from stabilizing the patient, the initial management of a patient with stroke depends on the type and etiology of stroke . While thrombolytic therapy benefits ischemic strokes, it is contraindicated in hemorrhagic ones . This process should be done fast, as there is a golden time of 4.5 h available from the symptom onset to safely use Tissue Plasminogen Activators (tPA), such as Alteplase [29, 30].
Confirmation of the stroke
Although a stroke is generally accompanied by clinical signs and symptoms, such as face drooping on one side, arm weakness, and difficulty in speech, this diagnosis should be confirmed by detecting signs of infarction and early signs of ischemia (such as presence of hyperdense area in a vessel—mainly in the middle cerebral artery—which is a common sign of intravascular thrombus or embolus) through imaging [31, 32]. In addition, although the collateral flow tends to compensate the lack of blood flow in the affected area, early signs such as hypoattenuation and loss of grey–white matter differentiation would be evident .
Determining the status of brain-supplying arteries
The status of brain-supplying arteries should be assessed in the work-up to specify the possible etiologies, indicate the damage severity, and determine the recurrence risk in some cases .
Rule out the stroke mimics
Common imaging modalities in healthcare settings
Ranging from Magnetic Resonance Imaging (MRI) to Computed Tomography Perfusion (CTP), there are various imaging techniques available [38, 39]. Different modalities of Computed Tomography (CT) include CT Angiography of head and neck (CTA), CTP, and noncontrast CT. As for MRI modalities, various measures can be useful, such as Apparent Diffusion Coefficient (ADC) Diffusion-Weighted Imaging (DWI), Gradient Recalled Echo (GRE), Fluid-Attenuated Inversion Recovery (FLAIR), and MR Angiography of head and neck (MRA) [40,41,42]. Although CT is still the preferred imaging modality in the early management of acute stroke, MRI with DW measure is more sensitive than noncontrast CT for the very early detection of acute ischemia and is shown to be more efficient than the first CT, second CT and MRI in the evaluation of patients who are presented within the 24 h . The main reason for this accuracy is the capability of the DW imaging to show the slight differences in diffusion of the water molecules across the membranes during the cytotoxic edema; therefore, more visually available contrast will be presented in contrast to CT imaging which requires significant amount water molecule activity and retention and more time to exhibit detectable contrasts [44, 45].
However, not all medical centers have convenient access to MRI, and due to patient contraindications and intolerance to MRI scans, the amount of time it takes, and despite providing more accurate insight in tissue and vascular pathology, CT is considered the first-line imaging study at most centers . Widespread availability, rapid scanning features, and ease of detecting intracranial hemorrhage make noncontract CT of the head an appealing choice in early acute stroke evaluation . Although, approaches including multimodal CT/MRI protocols seem to be valuable tools in prevention, diagnosis and tracking the pathologic course of stroke and therapeutic response of interventions . In addition, after the initial treatment is given and the acute emergency phase has passed, carotid ultrasound should be performed to evaluate the vessels’ status in terms of artery occlusion, decreased blood flow, and potential sources of embolism. The characteristics of the brain infarct (including the size and the location) are key findings to determine the subtype of stroke (Intracerebral hemorrhage, subarachnoid hemorrhage, and brain ischemia) .
Early signs of ischemic stroke in CT are chiefly described as hypoattenuation, loss of differentiation between the grey and the white matter, parenchymal swelling and edema, hyperattenuation of the MCA (middle cerebral artery), infarction in the territory of the brain-supplying arteries, and cortical sulcal effacement on the affected side [50,51,52]. The Alberta Stroke Program Early CT Score (ASPECTS) is a quantitative scoring system that evaluates early changes of MCA stroke, based on the topographic involvement of the MCA-supplying territories of the brain . For each area involved, one point is deducted from the total of ten points. Some clinical variations of ASPECTS have also been introduced, such as pc-ASPECTS which evaluates the stroke of the posterior circulation . On the other hand, speaking of MRI, an increase in DWI signals is evident from the first hours of the ischemic stroke . While the ADC mapping shows reduced signals, T1- and T2-weighted sequences do not show significant changes in the early hyperacute phase of the ischemic stroke (0–6 h after stroke) . T1-weighted MRI usually shows low signal intensity after 16 h, and T2-weighted MRI is usually high-signal after 8 h . Therefore, the presentations of different MRI sequences could determine the age of the infarct.
Non-invasive methods such as CT Angiography (CTA) or Magnetic Resonance Angiography (MRA) are accessible and typically used for screening [57, 58]. Although non-invasive imaging modalities prevent a significant number of stroke cases, choosing the right strategy may differ based on the time that has been passed from the transient ischemic attack . With intravenous administration of contrast, CTA can illustrate a precise anatomical picture of the vascular system with sufficient details . On the other hand, MRA is an appropriate modality to evaluate the dynamic changes, since the technique used in this imaging is based on changes in the vasculature flow . Four-dimensional CTA and MRA are also less invasive alternatives to determine the clot burden and grading the collateral blood flow in large vessel occlusions . CTA could be considered as the most appropriate approach to diagnose stenosis and occlusions . However, as the injection of contrast material can cause kidney failure, it requires a thorough history, which is not always possible and time permitting in an acute stroke situation [64, 65].
Role of ultrasonography in early identification of stroke
Ultrasound methods are also available as non-invasive measures, though they are practically used only for the evaluation of non-acute cerebrovascular accidents . In addition, strokes of large arteries and patients with transient ischemic attack (TIA) can possibly benefit from Carotid Duplex Ultrasound (mostly extracranial vessels) and Transcranial Doppler (mostly intracranial vessels), where both of them are non-invasive [43, 67]. Transcranial Doppler (TCD) relies on the physical phenomenon known as the Doppler effect . In this case, changes in sound wave frequencies secondary to the motion of the blood in the arteries are measured and evaluated usually by calculating the Doppler shift. In addition, The peak systolic, diastolic, and mean flow velocities, along with the Gosling pulsatility index are also usually calculated, providing vital information about blood flow and whether it is altered or absent, or there is a change in pulsatility of the concerned vessel [69, 70]. Detecting these changes helps the clinicians to find out about the presence of occlusion and determine if the vessel has been recanalized after the initiation of treatment or not. The previous studies have demonstrated that prehospital diagnosis of middle cerebral artery occlusion with or without microbubble contrast agents in stroke patients has a significant amount of sensitivity and specificity, and therefore, prehospital assessment with ultrasonography may provide therapeutic benefits for stroke patients . Especially utilizing imaging techniques that describe the morphologic characteristics of lesions that lead to embolic events is useful in the early stages of stroke pathology, with ultrasound being the leading modality for monitoring the plaque rupture and dynamic changes in the vessels . Doppler ultrasound may provide prognostic value that may guide the therapeutic approach in stroke patients and better risk scoring for stroke patients; As an example, previous studies reported that asymptomatic embolic signals, detected in patients with symptomatic carotid artery stenosis, may be useful in developing better risk score system for prognostic purposes and efficient antithrombotic therapy [73,74,75]. Table 1 provides a summary of the benefits and limitations of MRI, CT, and ultrasound.
Telemedicine and neuroimaging
Since the health burden of stroke has led to the development of specialized centers and units for providing stroke-related care, an increasing need for expanding a constant and reliable communication between these centers and the primary healthcare units is tangible. Therefore, new concepts such as telehealth and telemedicine have become bold, especially in emergencies, introducing even more specific terms, such as teleneurology and telestroke [76,77,78]. Telestroke aims to virtually examine the suspected stroke patient by evaluating the imaging results and providing clinical recommendations . Neuroimaging is the fundamental element of telediagnosis for stroke, and appropriate imaging would indicate the best treatment approach for each patient.
Not all stroke patients need a transfer to a comprehensive stroke center (CSC). Several indications have been defined for the patients in need of CSC transfer, including qualification for tPA administration (ischemic stroke who would remain in the golden time after the transfer), endovascular thrombectomy, large-vessel occlusion, and massive stroke [80, 81]. Apart from making the final decision for which patients should be transferred, the patients’ transfer time will also decrease significantly by implementing the telestroke strategies. From the several available modalities, CT is an essential for the primary units and local hospitals, since it benefits from availability in most emergency departments and rapid results. Based on the patient’s presentations, results of CT imaging, and the facilities of the primary unit, the stroke specialists might request the local team to perform vascular imaging, such as CTA, MRA, or Digital Subtraction Angiography (DSA) .
Providing a standard and detailed protocol for the application of telestroke could help the patients with a rapid and more successful management, and the healthcare system by reducing the patient burden.
According to the clinical importance of stroke and the advantages of early management, imaging plays a vital role in the patients’ survival. MRI is more accurate in ruling out the intracranial hemorrhage and MRI with DWI is more precise in the detection of acute ischemic stroke. However, due to the availability and lower acquisition time, CT is preferred in most healthcare settings. Being cognizant of the early warning signs of a stroke, alongside developing rapid, simple, and handy imaging techniques could help us improve the outcomes and overcome the burden of stroke.
Availability of data and materials
All data generated or analyzed during this study are included in this published article.
Apparent Diffusion Coefficient
Alberta Stroke Program Early CT Score
Cincinnati Prehospital Stroke Scale
Comprehensive stroke center
Computed tomography angiography
Computed Tomography Perfusion Imaging
Digital Subtraction Angiography
Face Arm Speech Time
Fluid-Attenuated Inversion Recovery
Gradient Recalled Echo
Kurashiki Prehospital Stroke Scale
Los Angeles Motor Scale
Los Angeles Prehospital Stroke Scale
Melbourne Ambulance Stroke Scale
Middle cerebral artery
Magnetic resonance angiography
Magnetic Resonance Imaging
National Institutes of Health Stroke Scale
Transient ischemic attack
Tissue Plasminogen Activators
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Akbarzadeh, M.A., Sanaie, S., Kuchaki Rafsanjani, M. et al. Role of imaging in early diagnosis of acute ischemic stroke: a literature review. Egypt J Neurol Psychiatry Neurosurg 57, 175 (2021). https://doi.org/10.1186/s41983-021-00432-y
- Brain infarction
- Cerebrovascular disorders
- Diagnostic imaging
- Intravenous thrombolysis