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Table 6 Factors affecting the Δ change of NIHSS and mRS after 6 months and mortality (using regression analysis)

From: Predictors of the functional outcome after thrombolysis in an Egyptian patients’ sample

  Δ Change of NIHSS
after 6 months
mRS after 6 months Mortality
  Univariate Univariate Univariate
P B (95% CI) P OR (95% CI) P OR (95% CI)
Dose (0.9) 0.617 − 0.565(− 2.8 to −  1.70) 0.541 0.685 (0.204 to 2.302) 0.111 0.168 (0.019 to 1.50)
Age (years) 0.629 − 0.025 (− 0.130 to 0.08) 0.054 1.070(0.999 to 1.145) 0.173 1.059 (0.975 to 1.15)
No of risk factors 0.855 0.081 (− 0.816 to 0.98) 0.306 1.277 (0.800 to 2.038) 0.195 1.50 (0.811 to 2.78)
Initial FASTED 0.906 0.346 (− 0.429 to 1.12) 0.011* 1.943*(1.163 to 3.245) 0.181 1.43 (0.845 to 2.43)
Initial RACE 0.958 − 0.017 (− 0.653 to 0.6) 0.001* 2.638*(1.507 to 4.617) 0.066 1.57 (0.971 to 2.54)
Initial NIHSS 0.005* 1.354*(1.098 to 1.668) 0.184 1.153 (0.935 to 1.42)
Onset-to-presentation time 0.340 − 0.013 (− 0.042 to 0.02) 0.181 1.010 (0.995 to 1.025) 0.958 1.0 (0.983 to 1.019)
Onset to tPA 0.313 − 0.017 (− 0.050 to 0.02) 0.154 1.013 (0.995 to 1.032) 0.997 1.00 (0.979 to 1.021)
ASPECT score 0.233 − 1.012 (− 2.72 to 0.685) 0.551 0.764 (0.316 to 1.848) 0.442 0.670 (0.241 to 1.862)
Hospital stay 0.001* − 0.139*(− 0.21 to − 0.06) 0.012* 1.174*(1.036 to 1.331) 0.179 1.035 (0.985 to 1.087)
SBP on admission 0.424 0.016 (− 0.024 to 0.06) 0.062 0.975 (0.950 to 1.001) 0.193 0.976 (0.941 to 1.012)
DBP on admission 0.575 0.021(− 0.053 to 0.09) 0.063 0.952 (0.904 to 1.003) 0.183 0.954 (0.891 to 1.02)
RBS on admission 0.260 − 0.007(− 0.019 to 0.01) 0.201 1.004 (0.998 to 1.010) 0.113 1.005 (0.999 to 1.012)
Sex (females) 0.109 1.80 (− 0.422 to 4.034) 0.503 0.667(0.203 to 2.184) 0.266 0.409 (0.085 to 1.97)
Initial CT brain (MCA sign) 0.491 0.469(− 0.89 to 1.836) 0.872 1.263 (0.074 to 21.54) 0.788 0.872 (0.320 to 2.37)
Stroke type
(cardioembolic LVO)
0.614 − 0.369 (− 1.84 to 1.10) 0.013* 18.33*(1.868 to 179.8) 0.099 0.222 (0.037 to 1.3)
Anterior vs. posterior circulation 0.100 5.611 (− 1.12 to 12.3) 0.872 1.263(0.074 to 21.54) 0.266 5.14 (0.286 to 92.3)
Hemorrhagic transformation 0.264 − 2.0(− 5.59 to 1.58) 0.069 8.0 (0.850 to 75.28) 0.299 2.750 (0.408 to 18.5)
Midline shift 0.012* − 2.96*(− 5.24 to − 0.69) 0.013* 16.0*(1.788 to 143.1) 0.151 2.486 (0.717 to 8.62)
  #Multivariate #Multivariate #Multivariate
  P B (95% CI) P OR (95% CI) P OR (95% CI)
Hospital stay 0.048* − 0.131*(− 0.261 to − 0.001)     
Initial RACE    0.048* 3.954*(1.010 to 15.481)   
  1. B Beta constant, OR odd`s ratio, CI confidence interval
  2. #All variables with p < 0.05 was included in the multivariate
  3. *Statistically significant at p ≤ 0.05
  4. Δ Change rate of change, NIHSS National Institutes of Health Stroke Scale, mRS modified Ranking score, CT computed tomography, FAST-ED Field Assessment Stroke Triage for Emergency Destination scale, RACE Rapid Arterial oCclusion Evaluation Scale, tPA tissue plasminogen activator, ASPECT Alberta stroke program early CT score, SBP systolic blood pressure, DBP diastolic blood pressure, RBS random blood glucose, MCA middle cerebral artery, LVO large vessel occlusion