Clinically isolated syndrome is a term describing the first neurological episode that could be suggestive of multiple sclerosis. This may create a diagnostic and therapeutic dilemma given the difficulty in predicting who will be converting to CDMS. Clinical presentation in combination with MRI of the brain and CSF analysis can be used in CIS patients to detect the patients who at risk for clinically definite MS (Alroughani et al. 2012). It was found in this study that eight patients (19.6%) of CIS after 1-year follow-up were converted to clinically definite MS in concordance to these results, those of Martinelli et al. (2014) which that stated that only 19% of their CIS patients had converted to clinically definite MS in the first year of follow-up, and those of Zhang et al. (2016) which found that 22% of patients with CIS converted to clinically definite MS in first year follow-up and 52% patients converted to clinically definite MS at 5-year follow-up.
It was shown that the CIS patients that converted to MS were younger (below 30 years old) than non-convertors in this study with tendency to reach to a significant level. Similar to this result, Alroughani et al. (2012) found that the mean age of the convertors was less than 30 years and independently associated with a higher risk of developing a second event within 2 years of onset. It was postulated that the African American patients had more rapid disease progression than non-white race/ethnicity and was associated with a higher risk of early second event which has been associated with poorer long-term prognosis (Mowry et al. 2009).
Although most of the convertors were females, there was no statistically significant difference in gender between the two groups, in agreement with this result, some studies (Alroughani et al. 2012; Dobson et al. 2012) that stated that there was no effect of gender on the conversion rate of CIS.
In respect to clinical presentation, it was found that most of convertors (75% of the patients) were initially presented with optic neuritis, and that the multivariate logistic analysis showed that optic neuritis presentation was an independent predictor for conversion after 1-year follow-up in this study. There was a conflict of results in the literature, as Kuhle et al. (2015) found that 31% of the convertors presented with optic neuritis and only 20% presented with spinal cord syndrome, while on the other side, some researchers (Alroughani et al. 2012; Miller et al. 2005) reported that optic neuritis was associated with a lower risk of developing MS than other types of clinically isolated syndrome. This conflict could be attributed to geographical variation in clinical presentation and length of follow-up.
In this study, it was found that there was no significant difference in disability assessed by EDSS between the convertors and non-convertors at baseline while the CIS patients that converted to CDMS showed significant worse EDSS scores after 1-year. It was suggested that the EDSS scores of the first attack may have no significant role in predicting early conversion for CDMS. Bi et al. (2016) studied the characteristics of the CIS patients and their risk factors for progression to MS or neuromyelitis optica(NMO), and it was shown that the average EDSS score of the NMO group was higher than that of the MS group, suggesting that the NMO disability was higher than that of MS. Therefore, the diagnosis of NMO should be paid attention to when the EDSS score of CIS was higher at their initial presentation.
It was suggested that the neurophysiological studies could predict conversion for CDMS in CIS patients as Swanton et al. (2006) study showed that 64% of CIS patients had VEP abnormal rate, and 24% of the patients had somatosensory evoked potential abnormal rate suggesting that the evoked potential studies were of great value for the prediction of CIS conversion. In this study, there was no significant difference in VEP results between convertors and non-convertors at baseline while, the convertors showed significant delayed p100 latency than non-convertors after 1-year. In agreement with these results, Bi et al. (2016) stated that the individually evoked potential was not predictable for CIS transformation. But the combination of two or three evoked potential anomalies may be helpful in prediction of CIS prognosis.
Conventional MRI has a well-established role in the initial assessment of patients with CIS. The risk for conversion to CDMS is greater in patients presenting with abnormal T2-weighted images. It was found that 50 to 70% of the patients with CIS may have asymptomatic abnormal T2-weighted images at their initial presentation (Miller et al. 2012). Several studies (Kuhle et al. 2015; Alroughani et al. 2012; Miller et al. 2012) had postulated that the number of MRI lesions at baseline was a strong predictor to MS conversion in the CIS patients as those who had ≥ 9 T2 lesion were at a higher risk for conversion. In this study, it was found that the patients that had converted to CDMS have a significant higher T2 lesion numbers at baseline and after 1-year follow-up. Moreover, the multivariate regression analysis had confirmed that higher MRI lesion number is an independent predictor of conversion.
Interestingly, it was found that the number of total MRI brain T2 lesion at the baseline that predict early conversion of CIS patients to MS was four lesions with sensitivity (100%) and specificity (85. 7%).While Martinelli et al. (Martinelli et al. 2014) stated that the number of MRI T2 lesions at baseline appeared to be predictive of CDMS was nine lesions. For patients with fewer than nine lesions, the conversion rate to CDMS was 50 vs. 66% for the patients with nine or more lesions. This difference in results could be attributed to the small numbers of patients and short duration of follow-up.
Although the previous studies (Brex et al. 1999; Pestalozza et al. 2005; Zivadinov et al. 2013) had postulated that the increased risk of conversion for MS was associated with the presence of gadolinium-enhancing lesions, there was no statistically significant difference in the total T1 lesion number between the converted and non-converted groups in this study. Accurate estimation of the incidence of Gd-enhancing lesions at CIS presentation is difficult because of inconsistent administration of contrast across studies. Gd-enhancing lesions may only be present in subjects with abnormal T2-weighted images (Brex et al. 1999). The presence of at least one Gd-enhancing lesion is predictive of time to CDMS in monofocal, but not in multifocal presentations (Nielsen et al. 2009).
This study had some limitations including a short-duration follow-up and small number of participants. Moreover, there is a lack of application of McDonald’s criteria 2017 in this study as this manuscript was submitted to the Egyptian journal of neurology before the publication of McDonald’s criteria 2017. It is highly recommended to have a further estimation of the CSF oligoclonal bands in the patients with CIS to fulfill dissemination of time to determine who will convert to CDMS according McDonald’s criteria 2017 in the upcoming studies.
