Table 5 Protein biomarkers, stroke severity and complications

1) NIHSS onset severity

a) Minor stroke < 5

37.21 ± 24.31

15.41 ± 24.39

760.10 ± 157.67

38.83 ± 14.30

6.19 ± 3.34

b) Moderate stroke 5–15

60.35 ± 56.28

5.43 ± 6.94

751.03 ± 171.12

84.83 ± 140.38

8.36 ± 8.38

c) Moderate to severe stroke 16–20

85.76 ± 78.12

5.13 ± 6.47

746.71 ± 186.35

55.66 ± 55.07

5.97 ± 4.07

d) Severe stroke 21–42

150.00 ± 100.41

3.82 ± 0.10

889.58 ± 61.74

72.71 ± 3.75

6.53

p value

0.085

0.05*

0.761

0.367

0.620

2) Neurological complications

a) Cerebral edema

117.89 ± 84.08

4.53 ± 3.94

765.08 ± 217.06

78.83 ± 135.18

7.55 ± 8.83

p value

0.001*

0.632

0.408

0.804

0.854

b) Seizures

113.59 ± 77.46

7.17 ± 8.99

778.59 ± 183.34

122.45 ± 264.37

7.60 ± 6.76

p value

0.028*

0.915

0.909

0.426

0.609

c) Occurrence of hemorrhagic transformation

86.39 ± 77.63

3.89 ± 2.04

712.36 ± 203.34

83.89 ± 131.85

6.35 ± 4.87

p value

0.123

0.195

0.191

0.049*

0.476

d) Hemorrhagic transformation grading

 -HT-1

43.86 ± 47.98

2.94 ± 0.76

711.48 ± 221.32

105.75 ± 217.38

6.80 ± 4.67

 -HT-2

84.50 ± 81.22

4.84 ± 2.84

640.39 ± 173.88

67.52 ± 81.74

6.64 ± 6.31

 -PH-1

94.50 ± 78.22

170.00 ± 170.00

3.35 ± 3.35

845.92 ± 845.92

8.49 ± 8.49

 -PH-2

131.94 ± 80.88

3.70 ± 1.00

804.71 ± 213.38

37.87 ± 13.99

4.90 ± 0.86

p value

0.019*

0.177

0.191

0.350

0.641

3) Non-neurological complications

a) Pneumonia

49.62 ± 46.18

5.71 ± 8.74

744.78 ± 165.97

79.99 ± 134.56

7.60 ± 7.48

p value

0.001*

0.040*

0.157

0.416

0.827

b) UTI

52.19 ± 50.07

5.38 ± 8.26

744.09 ± 169.59

79.23 ± 135.37

7.73 ± 7.66

p value

0.001*

0.274

0.162

0.608

0.993