Evaluation of peripheral and autonomic nervous systems dysfunctions in patients with Parkinson’s disease

Ragab, Osama A.; Mohamed, Ehab S.; Nassar, Mahmoud H.

doi:10.1186/s41983-024-00827-7

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery

Table 3 Mean values of nerve conduction study of studied groups and post hoc analysis

From: Evaluation of peripheral and autonomic nervous systems dysfunctions in patients with Parkinson’s disease

	Controls	Drug-naïve patients with PD	Patients with PD on dopaminergic drugs	F-value	p-value	Tukey test
Median motor
Latency (ms)	3.87 ± 0.27	3.78 ± 0.24	3.75 ± 0.32	0.666	0.575	P1:0.579 P2:0.585 P3:0.572
Amplitude (mv)	5.45 ± 0.61	5.94 ± 0.52	5 ± 0.85	2.26	0.097	P1:0.093 P2:0.081 P3:0.091
Conduction Velocity (m/s)	59.25 ± 4.67	58.15 ± 4.97	58.92 ± 4.79	0.173	0.192	P1:0.180 P2:0.195 P3:0.193
F-wave latency (ms)	27.17 ± 0.92	27.15 ± 0.87	27.39 ± 1.34	1.01	0.39	P1:0.38 P2:0.41 P3:0.37
Median sensory
Latency (ms)	2.2 ± 0.16	2.81 ± 0.11	3.4 ± 0.32	64.2	0.001	P1:0.001 P2:0.001 P3:0.001
Amplitude (µv)	26.5 ± 3	22.55 ± 4.5	18.21 ± 8.14	4.55	0.008	P1:0.007 P2:0.001 P3: 0.009
Conduction velocity (m/s)	56.1 ± 3.51	52.65 ± 6.16	49.29 ± 3.03	26.57	0.01	P1:0.02 P2:0.001 P3:0.03
Ulnar motor
Latency (ms)	2.98 ± 0.26	2.98 ± 0.20	3.05 ± 0.32	0.349	0.789	P1:0.768 p2:0.672 P3:0.732
Amplitude (mv)	8.35 ± 0.79	8.44 ± 0.71	7.83 ± 1.32	1.58	0.199	P1:0.232 P2:0.192 P3:0.187
Conduction velocity (m/s)	53.5 ± 3.25	53.55 ± 3.10	54.42 ± 4.22	2.33	0.08	P1:0.082 P2:0.067 P3:0.079
F-wave latency (ms)	29.19 ± 1.14	29.08 ± 0.73	29.87 ± 0.84	1.84	0.155	P1:0.192 P2:0.137 P3:0.142
Ulnar sensory
Latency (ms)	2.38 ± 0.130	2.44 ± 0.16	2.95 ± 0.21	25.44	0.025	P1: 0.042 P2: 0.012 P3:0.032
Amplitude (µv)	20.2 ± 1.67	18 ± 2.79	15.42 ± 4.99	7.42	0.015	P1: 0.01 P2: 0.01 P3:0.01
Conduction velocity (m/s)	62.35 ± 5.04	58.8 ± 5.81	48.59 ± 5.42	14.09	0.008	P1:0.009 P2: 0.001 P3:0.001
Radial sensory
Latency (ms)	2.22 ± 0.13	2.41 ± 0.16	2.78 ± 0.21	23.22	0.033	P1: 0.041 P2: 0.032 P3:0.029
Amplitude (µv)	17.10 ± 1.07	15.55 ± 2.94	13.50 ± 4.54	5.89	0.012	P1: 0.013 P2:0.008 P3:0.015
Conduction velocity (m/s)	69.4 ± 4.16	56.75 ± 6.54	49.79 ± 4.42	26.44	0.001	P1:0.001 P2:0.001 P3:0.001
Tibial nerve
Latency (ms)	5.16 ± 0.23	5.03 ± 0.14	5.15 ± 0.58	1.262	0.293	P1: 0.341 P2: 0.272 P3:0.313
Amplitude (mv)	5.5 ± 0.24	5.62 ± 0.21	5.3 ± 0.89	0.739	0.535	P1:0.512 P2: 0.522 P3:0.519
Conduction velocity (m/s)	56.85 ± 7.90	55.55 ± 5.95	57.73 ± 8.20	0.39	0.759	P1:0.723 P2:0.562 P3:0.234
F-wave latency (ms)	47.25 ± 1.94	46.93 ± 1.13	47.37 ± 3.22	1.785	0.156	P1: 0.097 P2: 0.088 P3:0.123
Peroneal nerve
Latency (ms)	4.86 ± 0.28	5.04 ± 0.3	6.06 ± 0.79	18.82	0.024	P1:0.059 P2:0.027 P3:0.018
Amplitude (mv)	3.48 ± 0.42	3.92 ± 0.44	2.87 ± 0.65	14.67	0.001	P1: 0.001 P2: 0.001 P3:0.001
Conduction velocity (m/s)	67.25 ± 8.92	65.47 ± 8.73	52.4 ± 8.62	7.85	0.001	P1: 0.001 P2: 0.001 P3:0.001
F-wave latency (ms)	46.25 ± 1.06	45.85 ± 1.07	46.23 ± 1.35	1.35	0.27	P1:0.137 P2: 0.279 P3:0.152
Sural nerve
latency (ms)	2.92 ± 0.13	3.22 ± 0.14	3.71 ± 0.24	40.71	0.001	P1: 0.001 P2: 0.001 P3:0.001
Amplitude (µv)	16.5 ± 1.9	12.33 ± 7.06	5.31 ± 1.57	9.28	0.001	P1: 0.001 P2:0.001 P3:0.001
Conduction velocity (m/s)	62.33 ± 4.08	57.8 ± 3.79	49.13 ± 2.53	28.72	0.001	P1:0.001 P2: 0.001 P3:0.001

(ms) millisecond; (mv) microvolt; (m/s) meter per second; (µv) microvot; P1 (control versus drug-naïve patients with PD). P2 (control versus patients on dopaminergic drugs). P3 (drug-naïve patients with PD versus patients on dopaminergic drugs)

Back to article page