Table 4 Relation of different SIRT1 genotypes with demographic, clinical and laboratory parameters among MS sufferers
From: Sirtuin-1 level and gene polymorphisms in multiple sclerosis
| Â | Age (years) | Disease duration | Fasting blood glucose mg/dl | Cholesterol mg/dl | Triglycerides mg/dl | HDL mg/dl | LDL mg/dl | |
|---|---|---|---|---|---|---|---|---|
rs7895833 | GG | 28.8 ± 10.5 | 3.5 ± 1.1 | 120.2 ± 21.6 | 174.7 ± 33.1 | 175.8 ± 32.3 | 32.4 ± 10.7 | 122.5 ± 25.7 |
GA | 24.4 ± 10.3 | 3.7 ± 1.0 | 131.8 ± 15.4 | 133.9 ± 37.8 | 118.9 ± 39.8 | 38.2 ± 10.8 | 77.5 ± 34.5 | |
AA | 21.0 ± 8.5 | 2.3 ± 1.0 | 126.6 ± 16.3 | 112.4 ± 22.6 | 113.8 ± 30.6 | 36.4 ± 9.1 | 57.8 ± 25.4 | |
P value | 0.4 | 0.13 | 0.5 | 0.04* | 0.6 | 0.7 | 0.001** | |
rs7069102 | GG | 33.3 ± 11.2 | 3.2 ± 0.1 | 123.2 ± 16.4 | 171.2 ± 38.6 | 172.4 ± 36.4 | 33.7 ± 12.3 | 110.6 ± 27.8 |
CG | 24.2 ± 11.8 | 3.8 ± 0.3 | 128.8 ± 17.3 | 136.3 ± 41.4 | 118.6 ± 33.4 | 34.4 ± 8.8 | 66.2 ± 15.6 | |
CC | 21.3 ± 11.6 | 3.3 ± 0.6 | 132.9 ± 17.0 | 142.2 ± 35.5 | 151.6 ± 29.0 | 31.7 ± 6.5 | 60.7 ± 23.1 | |
P value | 0.2 | 0.9 | 0.7 | 0.1 | 0.1 | 0.9 | 0.02* | |
rs2273773 | TT | 23.5 ± 11.8 | 3.1 ± 1.3 | 121.6 ± 17.0 | 149.1 ± 16.2 | 175.4 ± 37.3 | 36.0 ± 6.7 | 115.2 ± 25.4 |
TC | 22.3 ± 11.0 | 3.8 ± 1.5 | 132.9 ± 20.2 | 116.6 ± 14.3 | 123.2 ± 35.5 | 40.2 ± 6.5 | 70.8 ± 9.0 | |
CC | 15.0 ± 6.2 | 2.0 ± 0.6 | 125.3 ± 11.6 | 128.3 ± 14.0 | 111.1 ± 39.0 | 40.1 ± 7.5 | 56.9 ± 11.7 | |
P value | 0.2 | 0.8 | 0.5 | 0.04* | 0.09 | 0.5 | 0.002** | |