Sirtuin-1 level and gene polymorphisms in multiple sclerosis

Table 2 Distribution of SIRT1 genetic variants and allelic frequency among MS sufferers and control subjects

Variables			MS sufferers		Control subjects		95% CI	OR	P-value
Variables			No	%	No	%	95% CI	OR	P-value
rs2273773	Genotype	CC	48	40	62	52	0.37–2.24	1.35	0.01*
		CT	46	38	48	40	0.67–8.94	1.41
		TT	26	22	10	8	1.94–3.73	3.83
	Allele	C	70	58	90	75	0.43–5.52	3.86	0.006**
	Allele	T	50	42	30	25	1.48–2.27	1.41	0.006**
rs7895833	Genotype	GG	54	45	30	25	2.56–5.75	2.48	0.0004**
		AG	34	28	30	25	0.56–2.75	5.49
		AA	32	27	60	50	0.61–11.91	1.49
	Allele	G	72	60	48	40	1.91–3.71	3.98	0.002**
	Allele	A	48	40	72	60	0.47–2.22	1.01	0.002**
rs7069102	Genotype	CC	24	20	58	48	0.91–3.71	1.88	< 0.00001**
		CG	34	28	32	27	0.33–6.51	1.93
		GG	62	52	30	25	1.93–3.70	2.85
	Allele	C	42	35	66	55	0.49–2.23	1.04	0.002**
	Allele	G	78	65	54	45	1.73–3.94	3.38	0.002**