From: Sirtuin-1 level and gene polymorphisms in multiple sclerosis
 | MS sufferers | Control subjects | P value |
---|---|---|---|
Age (years) | 37.5 ± 5.5 | 36.05 ± 5.46 | 0.14 |
Sex | Â | Â | Â |
Female | 70 (58%) | 66 (55%) | 0.7 |
Male | 50 (42%) | 54 (45%) | Â |
Disease duration (years) | 4.61 ± 3.33 | – | – |
Mean age at onset of MS | 26.31 ± 7.86 | – | – |
Expanded Disability Status Scale | 2.34 ± 1.33 | – | – |
Disease course | Â | Â | Â |
Relapsing–remitting | 90 (75%) | – | – |
Progressive | 30 (25%) | Â | Â |
Total cholesterol (mg/dL) | 189 ± 38 180 ± 43 0.37 | 180 ± 43 | 0.08 |
Low-density lipoprotein (mg/dL) | 86 ± 29 | 80 ± 27 | 0.09 |
High-density lipoprotein (mg/dL) | 52 ± 5 | 53 ± 5 | 0.1 |
Triglycerides (mg/dL) | 85 ± 22 | 79 ± 28 | 0.06 |
Serum SIRT1 level (ng/ml) | 2.1 ± 0.25 | 3.4 ± 0.2 |  < 0.0001** |