Syntaxin 1A gene polymorphism in multiple sclerosis: a case–control study

Table 6 Comparisons between syntaxin alleles regarding different MS variables

Variables	C allele		P-value	Sig.	T allele		P-value	Sig.
	No	Yes			No	Yes
	Mean ± SD	Mean ± SD			Mean ± SD	Mean ± SD
Age (yrs)	24.3 ± 5.7	34.7 ± 8.9	0.06	NS	34.7 ± 8.9	33.3 ± 9.3	0.5	NS
Age of onset (yrs)	21.7 ± 4.9	28.3 ± 8.2	0.2	NS	28.2 ± 8.8	27.8 ± 7.1	0.8	NS
Disease duration (yrs)	2.7 ± 2.1	8.3 ± 5.9	0.3	NS	6.5 ± 5.9	5.5 ± 5.7	0.5	NS
Total number of attacks	3 ± 1.7	3.4 ± 2.7	0.8	NS	3.7 ± 2.8	2.7 ± 2.1	0.2	NS
Number of attacks in last 2 years	1.7 ± 0.6	1.4 ± 0.9	0.6	NS	1.5 ± 0.97	1.1 ± 0.66	0.2	NS
MS severity degree
EDSS	2.8 ± 2.3	3.4 ± 2.1	0.6	NS	3.6 ± 2	2.9 ± 2.3	0.2	NS
FSS	5.2 ± 0.81	4.2 ± 1.5	0.3	NS	4.2 ± 1.6	4.2 ± 1.4	0.9	NS
MRI plaques
Cortical and juxta cortical	7.3 ± 2.5	7.7 ± 2.7	0.8	NS	7.5 ± 2.6	8 ± 2.8	0.4	NS
Peri-ventricular	4.7 ± 1.5	5.1 ± 2.6	0.8	NS	5.1 ± 2.9	4.9 ± 2.03	0.9	NS
Infra-tentorial	0.33 ± 0.6	0.42 ± 1.3	0.9	NS	0.42 ± 1.5	0.4 ± 0.6	0.9	NS
Spinal cord	0.67 ± 0.6	0.61 ± 0.6	0.8	NS	0.64 ± 0.7	0.56 ± 0.6	0.6	NS
Cognitive assessment
CVLT	32 ± 8.9	33.7 ± 15.9	0.8	NS	33.7 ± 15.9	33.3 ± 15.3	0.9	NS
SDMT	42.7 ± 3.1	28.4 ± 17.4	0.2	NS	29.6 ± 17.8	27.7 ± 16.5	0.7	NS
BVMT	14.3 ± 2.1	10.3 ± 4.5	0.1	NS	10.8 ± 4.5	9.6 ± 4.3	0.2	NS

EDSS Expanded Disability Status Score, FSS Fatigue Severity Scale, BICAMS Brief International Cognitive Assessment, SDMT Symbol Digit Modalities Test, CVLT California Verbal Learning Test, BVRT Brief Visuospatial Retention Test, NS nonsignificant