Whole exome sequencing in a sample of Egyptian patients with covert cerebral small vessel disease

Table 2 Cases with positive pathogenic variants

	Case 1	Case 2
Age	57 years	68 years
Gender	Female	Male
Educational level	Secondary grade	Secondary grade
Education years	14	14
Risk factors
Smoking	No	Yes
Diabetes	No	No
Hypertension	Yes	No
Dyslipidaemia	No	No
ISHD	No	No
Previous CVS	No	No
Family history of similar condition	Yes	No
Age of onset	52	65
Duration of symptoms	5	3

First presenting symptom	Cognitive impairment	Cognitive impairment
MoCA	11/30	21/30
Berg Balance scale	16/56	32/56
10 MWT (m/sec)	0.25	0.49
ICIQ-SF	18/21	0/21
Fazekas scale	3	2
Small vessel disease scale	3	3
Global cortical atrophy scale	4	22

CVS Cerebrovascular stroke, MoCA Montreal Cognitive Assessment, 10MWT 10-m walk test, ICIQ-SF the Arabic International Consultation on Incontinence Questionnaire-Short Form Scale, SVD small vessel disease, ISHD ischemic heart disease