Baseline | 6 months | 12 months | p value | |
---|---|---|---|---|
Periventricular hyperintensity n (%) | ||||
Absent | – | – | – | 0.89 |
Cell lining | 20 | 21 | 21 | |
Smooth(halo) | 10 | 10 | 10 | |
Irregular | 10 | 9 | 9 | |
Occult lacunar brain infarcts mean ± SD | 0.56 ± 0.21 | – | 1.77 ± 0.51 | 0.001 |
Cortico-spinal diffusion tensor tractography mean ± SD | ||||
FA | 0.62 ± 0.13 | – | 0.51 ± 0.21 | 0.022 |
CST (density) | 388.0 ± 29.0 | – | 321.0 ± 56.0 | 0.009 |
Thalamao-cortical connectivity diffusion tensor tractography mean ± SD | ||||
FA | 0.75 ± 0.12 | – | 0.41 ± 0.15 | 0.001 |
TCC | 666.9 ± 74 | – | 649.2 ± 49 | 0.547 |
Arcuate fasciculus diffusion tensor tractography mean ± SD | ||||
FA | 0.47 ± 0.02 | – | 0.36 ± 0.06 | 0.001 |
TCC | 230.33 ± 74 | – | 237.14 ± 49 | 0.273 |
Mean cortical thickness | 3.12 ± 0.9 | – | 2.22 ± 0.8 | 0.031 |
MRI brain volumetric study | ||||
TCCV (mm3) | 589,456 ± 1689 | – | 559,152 ± 1459 | 0.001 |
TCWMV (mm3) | 521,546 ± 1785 | – | 501,306 ± 1259 | 0.012 |