The Egyptian Journal of Neurology, Psychiatry and Neurosurgery

Table 10 Effect of different monotherapy on lipid and thyroid parameters

From: Effect of anti-epileptic drugs usage on thyroid profile in Egyptian epileptic children

	Monotherapy															ANOVA
	Levetiracetam I			Carbamazepine II			Oxcarbazepine III			Valproic acid IV			Control V			ANOVA
	Mean	±	SD	Mean	±	SD	Mean	±	SD	Mean	±	SD	Mean	±	SD	F	P-value
T4	1.133	±	0.289	0.806	±	0.628	0.891	±	0.328	0.951	±	0.446	1.752	±	0.159	60.452	< 0.001*
TSH	2.155	±	1.221	1.411	±	1.003	2.073	±	0.952	2.922	±	2.422	0.885	±	0.428	16.316	< 0.001*
Total cholesterol	191.955	±	37.004	202.143	±	22.215	191.462	±	23.454	181.037	±	30.818	85.641	±	18.787	168.070	< 0.001*
Triglyceride	126.545	±	31.692	127.429	±	19.262	120.077	±	37.706	113.148	±	42.815	110.474	±	23.744	1.964	0.103
HDL-cholesterol	36.045	±	7.041	38.214	±	7.797	41.846	±	11.696	44.556	±	12.176	57.372	±	4.358	50.795	< 0.001*
LDL-cholesterol	131.045	±	32.406	138.571	±	31.578	122.462	±	24.801	117.852	±	27.931	78.269	±	13.275	45.646	< 0.001*

Tukey's test
	I&II	I&III	I&IV	I&V	II&III	II&IV	II&V	III&IV	III&V	IV&V
T4	0.027*	0.199	0.281	< 0.001*	0.960	0.646	< 0.001*	0.981	< 0.001*	< 0.001*
TSH	0.388	1.000	0.190	< 0.001*	0.624	0.002*	0.572	0.243	0.012*	< 0.001*
Total cholesterol	0.758	1.000	0.554	< 0.001*	0.803	0.084	< 0.001*	0.733	< 0.001*	< 0.001*
Triglyceride	1.000	0.972	0.528	0.178	0.969	0.599	0.297	0.960	0.822	0.995
HDL-cholesterol	0.922	0.201	0.002*	< 0.001*	0.735	0.095	< 0.001*	0.834	< 0.001*	< 0.001*
LDL-cholesterol	0.867	0.814	0.257	< 0.001*	0.350	0.047*	< 0.001*	0.974	< 0.001*	< 0.001*

TSH thyroid stimulating hormone, HDL high-density lipoprotein, LDL low-density lipoprotein, SD standard deviation, ANOVA analysis of variance. P value < 0.05 statistically significant, P value < 0.01 statistically highly significant

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