Table 1 Descriptive comparison of reports showing association of optic neuritis and COVID-19; MOG-myelin oligodendrocyte glycoprotein, ON-optic neuritis, RTPCR-reverse transcriptase polymerase chain reaction, HM-hand movement, PL-perception of light, PR-projection of rays, N/A-not assessable

Sawalha et al. [7]

Male, 44 years; bilateral ON

Right-6/60

Left-6/9

I/V Methylprednisolone

(1gm × 5 days)

Complete recovery in left eye with partial restoration of vision in right eye

RTPCR positive 2 weeks prior to optic neuritis; mild respiratory symptoms managed in home isolation

Detected

Zhou et al. [8]

Male, 26 years;

Bilateral sequential ON and TM

Right- HM, Left -6/75

I/V Methylprednisolone (1gm × 5 days) followed by oral prednisolone taper

6/9 vision in both eyes 3 weeks later

RTPCR positive at the time of clinical presentation; mildly symptomatic for COVID-19

Detected

Žorić et al. [9]

Male, 63 years; Right ON

Right- 6/190

I/V Methylprednisolone (1gm × 5 days) followed by oral prednisolone taper over two weeks

6/7.5 vision in right eye 3 weeks later

RTPCR negative serology (IgM, IgG) positive for COVID-19, 4 weeks prior to ON; moderate COVID-19 disease

Detected

François 2021 et al. [10]

Female, late 50 s; Right ON with retinitis

Right-HM

Oral and topical corticosteroids

HM in right eye after 45 days

RTPCR positive at time of clinical presentation; mild COVID-19 disease

Not mentioned

Benito-Pascual 2020 et al. [11]

Female, 50 years; left ON with panuveitis

Left-

6/60

Oral corticosteroids taper

6/12 in left eye

RTPCR positive at time of clinical presentation; moderate COVID-19 disease

Not mentioned

Rodríguez-Rodríguez MS et al. [12]

Female, 55 years; left ON

Left-

6/60

I/V Methylprednisolone × 5 days followed by oral prednisolone taper

6/120 in left eye after 4 weeks

RTPCR positive at time of clinical presentation; asymptomatic COVID-19

Not mentioned

Present series

1. Female, 8 months; bilateral ON

2. Female, 21 years; right ON

3. Male, 16 years; left ON

1. N/A

2. Right-3/60

3. Left- PL/PR

1.I/V Methylprednisolone (15 mg/kg) × 3 days followed by oral prednisolone taper

2.I/V Methylprednisolone (1gm/kg) × 3 days followed by oral prednisolone taper

3.I/V Methylprednisolone (1gm/kg) × 3 days followed by oral prednisolone taper

1. N/A

2. Right-6/60 after 3 weeks

3. Left-6/60 after 4 weeks

1.RTPCR positive at time of clinical presentation; asymptomatic COVID-19

2.RTPCR positive 15 days prior to ON; Mild COVID-19 disease

3. RTPCR positive at time of clinical presentation; asymptomatic COVID-19 disease

1. Negative

2. Negative

3. Negative