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Table 6 Correlation of the psychiatric scales with MRI volumetry, DTI, 5-HT and 5-HIAA in PD patients

From: Role of multimodal advanced biomarkers as potential predictors of cognitive and psychiatric aspects of Parkinson's disease

Studied variables

HDRS

BDI-II

R

P value

r

P value

Volumetric MRI

Frontal cortical thickness

 RT

− 0.492

 < 0.001*

− 0.590

 < 0.001*

 LT

− 0.575

 < 0.001*

− 0.541

 < 0.001*

Temporal cortical thickness

 RT

− 0.454

 < 0.001*

− 0.514

 < 0.001*

 LT

− 0.617

 < 0.001*

− 0.545

 < 0.001*

Insular cortex thickness

 RT

− 0.493

 < 0.001*

− 0.560

 < 0.001*

 LT

− 0.544

 < 0.001*

− 0.548

 < 0.001*

Cingulate thickness

 RT

− 0.454

 < 0.001*

− 0.556

 < 0.001*

 LT

− 0.513

 < 0.001*

− 0.559

 < 0.001*

Parahippocampal thickness

 RT

− 0.405

0.002*

− 0.492

 < 0.001*

 LT

− 0.551

 < 0.001*

− 0.582

 < 0.001*

Hippocampal volume

 RT

− 0.597

 < 0.001*

− 0.548

 < 0.001*

 LT

− 0.577

 < 0.001*

− 0.579

 < 0.001*

Amygdala volume

 RT

− 0.574

 < 0.001*

− 0.581

 < 0.001*

 LT

− 0.582

 < 0.001*

− 0.577

 < 0.001*

DTI

SOFF (FA)

 RT

− 0.400

0.002*

− 0.395

0.002*

 LT

− 0.361

0.005*

− 0.369

0.004*

SOFF (MD)

 RT

0.305

0.020*

0.385

0.003*

 LT

0.313

0.017*

0.437

0.001*

IOFF (FA)

 RT

− 0.539

 < 0.001*

− 0.545

 < 0.001*

 LT

− 0.481

 < 0.001*

− 0.481

 < 0.001*

IOFF (MD)

 RT

0.324

0.013*

0.282

0.032*

 LT

0.353

0.007*

0.417

0.001*

Temporal subcortical tract (MD)

 RT

0.477

 < 0.001*

0.275

0.036*

 LT

0.249

0.059

0.326

0.012*

Cingulum (FA)

 RT

− 0.489

 < 0.001*

− 0.380

0.003*

Cingulum (MD)

 LT

0.142

0.286

0.337

0.010*

Laboratory

5-HT (ng/ml)

− 0.079

0.557

− 0.031

0.820

5-HIAA (mg/24 h)

− 0.014

0.916

− 0.205

0.122

2-A Ct

0.186

0.163

0.072

0.590

  1. *Significant at p < 0.05, r: Pearson correlation coefficient