Role of multimodal advanced biomarkers as potential predictors of cognitive and psychiatric aspects of Parkinson's disease

Badr, Marwa Y.; Amer, Reham A.; Kotait, Mona A.; Shoeib, Sara M.; Reda, Alaa M.

doi:10.1186/s41983-023-00662-2

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery

Table 3 DTI and SWI in PD patients and control subjects

From: Role of multimodal advanced biomarkers as potential predictors of cognitive and psychiatric aspects of Parkinson's disease

DTI and SWI	Groups: mean ± SD		T test
	Patients	Controls	T	P value
SOFF (FA)
RT	0.314 ± 0.068	0.378 ± 0.026	− 5.967	< 0.001*
LT	0.318 ± 0.070	0.387 ± 0.024	− 6.301	< 0.001*
SOFF (MD)
RT	5.491 ± 1.034	4.704 ± 0.031	5.096	< 0.001*
LT	7.307 ± 0.696	6.757 ± 0.060	5.282	< 0.001*
IOFF (FA)
RT	0.295 ± 0.065	0.352 ± 0.013	− 5.722	< 0.001*
LT	0.298 ± 0.061	0.354 ± 0.018	− 6.003	< 0.001*
IOFF (MD)
RT	8.136 ± 0.704	7.502 ± 0.039	6.023	< 0.001*
LT	5.452 ± 1.024	4.518 ± 0.040	6.103	< 0.001*
Frontal subcortical tract (FA)
RT	0.146 ± 0.055	0.264 ± 0.018	− 13.791	< 0.001*
LT	0.119 ± 0.053	0.227 ± 0.013	− 13.221	< 0.001*
Frontal subcortical tract (MD)
RT	6.407 ± 0.715	5.633 ± 0.226	6.990	< 0.001*
LT	5.768 ± 0.625	4.523 ± 0.220	12.754	< 0.001*
Parietal subcortical tract (FA)
RT	0.146 ± 0.050	0.250 ± 0.013	− 13.682	< 0.001*
LT	0.153 ± 0.052	0.203 ± 0.013	− 6.244	< 0.001*
Parietal subcortical tract (MD)
RT	6.529 ± 0.792	5.278 ± 0.158	10.419	< 0.001*
LT	6.581 ± 0.822	4.846 ± 0.118	14.035	< 0.001*
Temporal subcortical tract (FA)
RT	0.150 ± 0.049	0.266 ± 0.018	− 14.930	< 0.001*
LT	0.107 ± 0.036	0.172 ± 0.012	− 11.442	< 0.001*
Temporal subcortical tract (MD)
RT	4.934 ± 0.499	3.902 ± 0.061	13.788	< 0.001*
LT	8.447 ± 0.530	7.769 ± 0.095	8.461	< 0.001*
Temporal subcortical tract (MD)
Cingulum (FA)
RT	0.315 ± 0.080	0.461 ± 0.017	− 12.085	< 0.001*
LT	0.433 ± 0.100	0.6 ± 0.056	− 1.297	0.198
Cingulum (MD)
RT	4.043 ± 0.471	2.997 ± 0.189	14.031	< 0.001*
LT	4.685 ± 0.701	3.650 ± 0.224	9.527	< 0.001*
Corona radiata (FA)
RT	0.282 ± 0.038	0.382 ± 0.017	− 16.608	< 0.001*
LT	0.386 ± 0.046	1.663 ± 7.827	− 1.245	0.216
Corona radiata (MD)
RT	5.939 ± 0.307	5.324 ± 0.190	11.787	< 0.001*
LT	6.448 ± 0.470	5.702 ± 0.094	10.473	< 0.001*
Corona radiata (MD)
Cerebral peduncle (FA)
RT	0.610 ± 0.046	0.717 ± 0.035	− 12.999	< 0.001*
LT	1.262 ± 6.111	0.568 ± 0.040	0.760	0.449
Cerebral peduncle (MD)
RT	5.524 ± 0.565	4.698 ± 0.252	9.125	< 0.001*
LT	7.827 ± 0.515	7.516 ± 0.243	3.741	< 0.001*

Chi-Square Test	N	%	N	%	X²	P value
SWI
Not blooming	39	67.24	43	95.56	12.645	0.002*
Blooming with iron	16	27.59	2	4.44
Minute calcification	3	5.17	0	0.00

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