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The Egyptian Journal of Neurology, Psychiatry and Neurosurgery

Table 2 Volumetric MRI in PD patients and control subjects

From: Role of multimodal advanced biomarkers as potential predictors of cognitive and psychiatric aspects of Parkinson's disease

Volumetric MRI

Groups: mean ± SD

T test

 

Patients

Control

T

P value

Frontal cortical thickness

 RT

2.041 ± 0.093

2.321 ± 0.202

− 9.344

 < 0.001*

 LT

2.004 ± 0.076

2.225 ± 0.076

− 14.670

 < 0.001*

Temporal cortical thickness

 RT

2.145 ± 0.120

2.409 ± 0.242

− 7.236

 < 0.001*

 LT

1.956 ± 0.156

2.454 ± 0.199

− 14.254

 < 0.001*

Insular cortex thickness

 RT

2.209 ± 0.095

2.582 ± 0.173

− 13.900

 < 0.001*

 LT

2.248 ± 0.123

2.737 ± 0.180

− 16.322

 < 0.001*

Precuneus thickness

 RT

2.104 ± 0.119

2.444 ± 0.103

− 15.254

 < 0.001*

 LT

2.099 ± 0.123

2.414 ± 0.080

− 14.877

 < 0.001*

Lingual thickness

 RT

1.270 ± 0.173

1.845 ± 0.116

− 19.224

 < 0.001*

 LT

1.558 ± 0.154

1.884 ± 0.075

− 13.042

 < 0.001*

Cingulate thickness

 RT

2.024 ± 0.214

2.486 ± 0.219

− 10.743

 < 0.001*

 LT

2.006 ± 0.165

2.414 ± 0.230

− 10.480

 < 0.001*

Parahippocampal thickness

 RT

2.852 ± 0.124

2.937 ± 0.043

− 4.422

 < 0.001*

 LT

2.076 ± 0.129

2.565 ± 0.237

− 13.372

 < 0.001*

Mean cortical thickness

 RT

2.278 ± 0.158

2.441 ± 0.059

− 6.572

 < 0.001*

 LT

2.278 ± 0.191

2.453 ± 0.075

− 5.805

 < 0.001*

Hippocampal volume

 RT

3321.845 ± 135.165

3920.444 ± 291.678

− 13.844

 < 0.001*

 LT

3192.724 ± 306.639

4120.733 ± 412.457

− 13.099

 < 0.001*

Amygdala volume

 RT

1446.707 ± 178.107

2007.000 ± 234.008

− 13.802

 < 0.001*

 LT

1446.655 ± 151.143

1844.578 ± 129.488

− 14.095

 < 0.001*

Accumbens area volume

 RT

344.397 ± 67.129

528.511 ± 74.795

− 13.133

 < 0.001*

 LT

258.707 ± 53.046

445.511 ± 84.663

− 13.701

 < 0.001*

Cerebral WM volume

 Total

340,317.017 ± 1449.507

363,046.089 ± 15,914.589

− 10.834

 < 0.001*

Cortical volume

 Total

389,713.138 ± 2456.608

408,564.933 ± 8789.853

− 15.587

 < 0.001*

Gray matter volume

 Total

542,201.879 ± 15,146.572

579,925.356 ± 17,505.207

− 11.710

 < 0.001*

Caudate volume

 RT

3039.552 ± 277.363

4077.733 ± 229.497

− 20.287

 < 0.001*

 LT

3160.138 ± 261.459

3832.822 ± 250.058

− 13.199

 < 0.001*

  1. SD: standard deviation, WM white matter
  2. *Significant at p < 0.05
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