The early clinical and laboratory predictors of GBS outcome: hospital-based study, Assiut University, Upper Egypt

Khedr, Eman M.; Mohamed, Mohamed Zayed; Shehab, Mohamed Mostafa M.

doi:10.1186/s41983-023-00646-2

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery

Table 2 Spearman correlations of clinical data and baseline laboratory findings with 3-month outcome using the Hughes Disability Scale (HDS) and Overall Neuropathy Limitation Scale (ONLS)

From: The early clinical and laboratory predictors of GBS outcome: hospital-based study, Assiut University, Upper Egypt

Clinical and laboratory variables	HDS at 3 months outcome (0–7)	ONLS at 3 months outcome (0–12)
Age groups
Correlation coefficient	0.253^*	0.299*
Sig0. (2-tailed)	0.047	0.02
Gender
Correlation coefficient	− 0.015	− 0.012
Sig. (2-tailed)	0.907	0.93
Comorbidity
Correlation coefficient	0.264*	0.287*
Sig. (2-tailed)	0.038	0.03
Duration between antecedent event and onset of weakness
Correlation coefficient	− 0.114	− 0.134
Sig. (2-tailed)	0.379	0.306
Number of days of antecedent event
Correlation coefficient	− 0.066	− 0.001
Sig. (2-tailed)	0.612	0.99
Days between onset and admission scale
Correlation coefficient	0.173	− 0.015
Sig. (2-tailed)	0.178	0.91
Presence of antecedent event
Correlation coefficient	0.395^**	0.418**
Sig. (2-tailed)	0.001	0.001
Respiratory antecedent event
Correlation coefficient	0.046	0.047
Sig. (2-tailed)	0.720	0.719
Presence of diarrhea (antecedent)
Correlation coefficient	0.391^**	0.426**
Sig. (2-tailed)	0.002	0.001
MRC sum score at nadir
Correlation coefficient	0.368^**	− 0.446***
Sig. (2-tailed)	0.003	0.0001
MRC sum score at onset
Correlation coefficient	− 0.367^**	− 0.456***
Sig. (2-tailed)	0.003	0.0001
MRC sum score at the 10th days of treatment
Correlation coefficient	− 0.626***	− 0.71***
Sig. (2-tailed)	0.0001	0.0001
EGRIS risk total score at onset
Correlation coefficient	0.378*	0.350**
Sig. (2-tailed)	0.002	0.006
Mechanical ventilation
Correlation coefficient	0.242	0.305*
Sig. (2-tailed)	0.059	0.018
ICU admission
Correlation coefficient	0.307^*	0.273*
Sig. (2-tailed)	0.015	0.035
Impaired cough reflex
Correlation coefficient	0.307^*	0.273*
Sig. (2-tailed)	0.015	0.035
Autonomic affection
Correlation coefficient	0.425^**	0.41**
Sig. (2-tailed)	0.001	0.001
Cranial nerve affection
Correlation coefficient	0.235	0.188
Sig. (2-tailed)	0.065	0.15
Neck muscle affection
Correlation coefficient	0.401^**	0.347**
Sig. (2-tailed)	0.001	0.007
Sensory onset
Correlation coefficient	− 0.186	− 0.146
Sig. (2-tailed)	0.148	0.264
Leukocytosis (WBC)
Correlation coefficient	0.136	0.08
Sig. (2-tailed)	0.291	0.49
Serum protein level
Correlation coefficient	− 0.220	− 0.18
Sig. (2-tailed)	0.086	0.169
Serum albumin level
Correlation coefficient	− 0.380^**	− 0.263**
Sig. (2-tailed)	0.002	0.042
Serum sodium level
Correlation coefficient	− 0.310^**	− 0.404**
Sig. (2-tailed)	0.014	0.001
C-reactive protein (CRP)
Correlation coefficient	0.287^*	0.223
Sig. (2-tailed)	0.024	0.125
Cytoalbuminous dissociation
Correlation coefficient	0.347*	0.418**
Sig. (2-tailed)	0.024	0.006
Management plan
Correlation coefficient	− 0.144	− 0.31*
Sig. (2-tailed)	0.264	0.016

*P value < 0.05, **P < 0.01, ***P < 0.0001
MRC Medical Research Council score, EGRIS Erasmus GBS respiratory insufficiency score

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