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Table 1 Characteristics of included trials (n = 6)

From: Effect of transcranial direct current stimulation in combination with robotic therapy in upper limb impairments in people with stroke: a systematic review

Trial

Study design

Participants

Sample size

Age (in years)

Gender (M/F)

Primary outcome measures

Secondary outcome measures

Dehem et al. [39]

Randomized, controlled, cross-over double-blind study

Chronic stroke patients

21

Age range: 36–81 years (mean 60.5)

15/6

BBT and Purdue Pegboard tests

–

Edwards et al. [40]

Double-blinded, randomized controlled trial

Chronic ischemic stroke patients > 6-month post-injury

82

Age range: 42–90 years (mean 67.8)

Not reported

Change in upper-limb impairment: FM-UE

Functional change: the Wolf Motor Function Test

Functional change: BI and SIS

Mazzoleni et al. [3]

Randomized, sham-controlled trial

Subacute stroke subjects, ischemic and haemorrhagic

24

Age range 42–88 (mean age 72.63 ± 10.78 years)

7/17

Upper limb evaluation: FM-EU, MAS/w, MI, and BBT

–

Mazzoleni et al. [41]

A single-blind, randomized, sham-controlled trial

Subacute stroke patients (25 ± 7 days from stroke onset time)

40

CG—68.74 ± 15.85 (24–88)

EG—67.50 ± 16.30(18–86)

Not reported

FMAS-UE, MAS/w, MI, and BBT

–

Straudi et al. [36]

Double-blinded exploratory RCT pilot study

First stroke-ischemic or hemorrhagic

23

Mean age

EG—52.7

CG—64.3

12/11

FMAS-UE, BBT, MAL

–

Triccas et al. [4]

Double-blinded randomised controlled

 > 2 week post-stroke

23

Age range 37–83 (mean age 63.4 years)

14/9

FMAS-UE

ARAT, MAL, SIS

  1. BBT Box and Block test, FMAS-UE Upper sub-section of Fugl–Meyer Assessment scale, BI Barthel Index, SIS Stroke Impact Scale, MAS/w Modified Ashworth Scale of wrist, MI Motricity Index, MAL Motor Activity Log 28, ARAT Action Research Arm test,SIS Stroke Impact Scale, EG Experimental Group, CG Control Group