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Table 3 Comparison of the psychometric tests and radiological data in epileptic patients as regard the antiseizure medication(ASM)

From: Could thalamic biochemical changes correlate to cognitive impairment in idiopathic generalized epilepsy?

 

Antiseizure medications(ASM)

P-value

Monotherapy (n = 15)*

Polytherapy (n = 15)

Psychometric tests

 IQ test

100.2 ± 4.6

100.6 ± 3.8

0.8

 DST

6.9 ± 1.1

7.1 ± 0.92

0.6

 WMS

26.2 ± 5.02

27.3 ± 5.8

0.5

 CDT

24.5 ± 4.03

23.3 ± 3.9

0.4

 Trail Making A

39.5 ± 6.6

43 ± 8.2

0.2

 Trail Making B

104.8 ± 11.8

117.6 ± 14.5

0.01*

 COWAT-phenomic

32.7 ± 4.5

35.7 ± 6.6

0.2

 COWAT-semantic

11.6 ± 1.7

12.1 ± 2.2

0.5

Radiological data

 NAA

13.9 ± 3.9

13.3 ± 2.8

0.6

 Choline

2.3 ± 0.61

2.3 ± 0.51

0.7

 Creatinine

8.7 ± 2.7

8.1 ± 2.2

0.5

 NAA/choline

6.5 ± 2.4

6.3 ± 1.6

0.8

 NAA/creat

1.8 ± 0.76

1.7 ± 0.45

0.9

 Choline/create

0.29 ± 0.09

0.30 ± 0.12

0.8

  1. Bold indicates *p < 0.05 is considered significant
  2. IQ intelligent quotient, DST digit span test, WMS-R Weschler memory scale, CDT cube drawing test, COWAT controlled oral word association test, NAA N-Acetyl aspartate
  3. *Monotherapy: Na Valproate, Polytherapy: Na Valproate and levetiracetam or valproate and lamotrigine