Fig. 1
From: Emerging hallmark of gliomas microenvironment in evading immunity: a basic concept
Schematic of CTLA-4 activate (a) and blockade (b); steps involved in generation of tumor-specific T cells. The figure shown is a schematic of an APC, with associated cell–cell interactions via CTLA-4/B7. Tumor-associated antigens or neo-antigens are presented by MHC on APCs or tumor cells to T cells with appropriate TCR. CD28 co-activating receptor on T cells binds B7 on APCs. Schematic of PD-1/PD-L1 blockade (c) and activate (d); steps involved in generation of tumor-specific T cells. Anti-PD-1 and PD-L1antibodies are shown