Fig. 1

Magnetic resonance imaging (MRI) brain of patient 1 (A–C). A, B Fluid-attenuated Inversion Recovery (FLAIR) axial images showing hyperintense lesion in midbrain and gliosis in right occipital area (red arrows); C coronal T2 image showing cascade sign (red arrow). MRI of patient 3 (D–F), (D, E) axial T2 and T1 image showing pontine base discrete hyperintense and hypointense lesion (red arrow); F axial T1 image showing decrease in lesion with treatment