Table 1 Clinical, radiological and biological data of patients with thymic plasmacytoma revealing a multiple myeloma
From: Thymic plasmacytoma presenting as polyneuropathy and revealing multiple myeloma: a case report
Patient N° | Age/sex | Medical history | Symptoms leading to consultation | MRI /CT | Initial diagnosis | Mediastinal mass biopsy | BMB: marrow involvement (%) | CRAB criteria | Beta microglobulin | Serum protein electrophoresis + immunofixation | Diagnostic criteria for MM |
|---|---|---|---|---|---|---|---|---|---|---|---|
1 [7] | 53/F | NM | Protruding mass on the right chest wall + local pain Fatigue | 48.7 × 60 × 52 mm mass in the thymus | Malignant thymoma | Plasmacytoma | 57% | Anemia (95 g/l) | Elevated (24.30 mg/L) | Monoclonal protein negative in the serum | Clonal bone marrow plasma cell ≥ 10% + Biopsy-proven EMP + Anemia |
2 [14] | 66/F | GERD Osteoporosis Hypercholesterolemia Smoking | Low back pain Nausea Retching Dyspnea | − 3.9 × 4.2 cm mass in the thymus – 8th right rib fracture – abnormal BM signal in multiple areas | Lung cancer with mediastinal involvement and skeletal metastasis | 10% | Anemia (107 g/l) | Elevated (5.2 mg/L) | |||
Our patient | 48/F | None | Gradually ascending distal paresthesias in the lower limbs Gait disorders | – 36 × 36 × 50 mm mass in the thymus – Pleural effusion – 5th rib lytic lesion with cortical bone rupture and soft tissue extension | Thymic plasmacytoma | 5% | ≥ 1 osteolytic lesion | Elevated (7 g/L) | IgA lambda monoclonal gammapathy | Biopsy-proven EMP + ≥ 1 osteolytic lesion |