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The Egyptian Journal of Neurology, Psychiatry and Neurosurgery
Fig. 2 | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery

Fig. 2

From: Effect of Letrozole on hippocampal Let-7 microRNAs and their correlation with working memory and phosphorylated Tau protein in an Alzheimer's disease-like rat model

Fig. 2

Sections in the hippocampus for confirmation of neurodegeneration in the STZ animals. a Section from normal hippocampus showing normal thickness of the pyramidal layer with rounded granular cells (arrows). Astrocytes (circles) and blood vessels (V) are found in the molecular layer (Hematoxylin and Eosin ×400) b Section from STZ-induced AD hippocampus with CA2 showing some degenerated pyramidal cells with neurofibrillary tangles (arrowheads) within the normal pyramidal cells (arrows), cell loss (asterisks) and other vacuolated cells (V) in the basal layer of pyramidal cells. Enlarged and excess astrocytes (circles) are found in the molecular layer (downward) and the polymorphic layer (upward). Depositions of amyloid protein (broken arrows) are found in the molecular layer (Hematoxylin and Eosin ×400)

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