Post-SARS-CoV-2 vaccination venous sinus thrombosis: a literature review of 308 cases

Finsterer, Josef; Zarrouk, Sinda

doi:10.1186/s41983-021-00431-z

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery

Table 1 Patients with post-SARS-CoV-2 vaccination VST reported in the literature

From: Post-SARS-CoV-2 vaccination venous sinus thrombosis: a literature review of 308 cases

Age	Sex	Dose	Company	locSVT	Latency (days)	Therapy	Outcome	References
53	f	1st	A	Cavernous	11	Intubation, platelets	Death	[9]
55	m	1st	A	Cavernous	8	Steroids, argatroban	Death	[9]
30*	f	1st	A	Transverse, sigmoid	7	Argatroban, IVIG	PR	[10]
30	f	1st	A	nr	9	Tinzaparin, rivaroxaban	PR	[11]
27*	m	1st	A	nr	2	Dabigatran, IVIG	Death	[12]
54*	m	nr	A	nr	14	Danaparoid, IVIG, DOAC	Alive	[13]
49	m	1st	P	Transverse, sigmoid	16	Clexane, apixaban	Alive	[14]
69	f	1st	A	Sigmoid, SSS	11	nr	Death	[5]
32	m	1st	A	SSS	9	None	Death	[14]
25*	m	1st	A	SSS	6	Heparin, platelets, IVIG, steroids	Death	[14]
22	f	1st	A	SSS, transverse	4	Enoxaparin, dabigatran	PR	[15]
46	f	1st	A	SSS, sigmoid, transverse	8	Danaparoid, dabigatran	PR	[15]
36	f	1st	A	SSS, straight	7	Enoxaparin, dabigatran	CR	[15]
50	m	1st	A	Transverse, sigmoid	7	Craniotomy	Death	[16]
61	f	nr	A	nr	14	Enoxaparin	Discharged	[17]
40	m	1st	A	nr	14	Enoxaparin, apixaban	Discharged	[17]
50	m	1st	A	SSS, sigmoid	7	Enoxaparin, craniotomy	Death	[18]
42	f	1st	A	SSS, straight sigmoid	0	Enoxaparin, craniotomy	Coma	[18]
55	f	2nd	P	Straight, sigmoid	1	Enoxaparin	Death	[18]
32	f	1st	A	Straight, sigmoid	1	Fondaparinux, steroids	Death	[18]
35	f	1st	A	SSS, straight sigmoid	6	Enoxaparin, steroids, PE	Coma	[18]
51	f	1st	A	Straight, sigmoid	10	Ventriculostomy	Death	[18]
64	m	1st	A	SSS, straight, sigmoid	4	Enoxaparin	CR	[18]
40	f	1st	A	SSS, straight sigmoid	5	Fondaparinux	PR	[18]
49	f	1st	A	straight, sigmoid	11	Enoxaparin	PR	[18]
54	f	1st	A	SSS, Galen	2	Enoxaparin, steroids	Death	[18]
55	f	1st	A	Jugular	6	Fondaparinux craniotomy	Death	[18]
54	f	nr	A	Labbe, Galen	12	Intubation	Death	[20]
39	f	1st	A	Sigmoid, transverse	6	Danaparoid dabigatran, IVIG	CR	[20]
24*	f	1st	A	Cortical	8	Argatroban, steroids, IVIG	CR	[21]
32	f	1st	A	nr	11	nr	Death	[22]
29*	m	1st	A	Sigmoid, transverse	9	IVIG, agratroban	Recovery	[23]
>40	nr	nr	J	Transverse, sigmoid	6	nr	ND	[23]
18-39	nr	nr	J	Transverse, sigmoid	9	nr	Discharged	[23]
18-39	nr	nr	J	SSS, straight,	8	nr	ND	[23]
18-39	nr	nr	J	Transverse, sigmoid	8	nr	Discharged	[23]
18-39	nr	nr	J	Transverse, sigmoid	6	nr	ND	[23]
>40	nr	nr	J	Transverse, straight	13	nr	ND	[23]
18-39	nr	nr	J	SSS, straight, transverse	15	nr	ND	[23]
18-39	nr	nr	J	Transverse, sigmoid	10	nr	Discharged	[23]
>40	nr	nr	J	SSS, cortical	7	nr	ND	[23]
18-39	nr	nr	J	Transverse, SSS, sigmoid	7	nr	ND	[23]
18-39	nr	nr	J	Transverse, sigmoid	11	nr	ND	[23]
>40	nr	nr	J	Transverse, sigmoid	6	nr	Discharged	[24]
51	m	1st	C	SSS, transverse	6	Heparin, warfarin	PR	[25]
40	f	1st	J	nr	5	Bivalirudin	CR	[26]
36	f	1st	A	SSS	14	Enoxaparin	Death	[27]
25	f	1st	A	Cortical	12	nr	nr	[28]
50*	m	1st	A	Transverse, sigmoid	14	Desirudin	PR	[29]
30*	f	1st	A	None	8	Tinzaparin	PR	[11]
ϴ46.7 (n = 45)	35f	1st (42)	A (n = 37)	nr	nr	nr	nr	[30]
		2nd (3)	P (n = 8)
32-81 (n = 213)	138 f 46 m	1st (except 2)	P (n = 25) M (n = 1) A (n = 187)	nr	2-21d	nr	Death (n = 46)	[31]

A: ChAdOx1-S, C: ChAdOx1-S from India, CR: complete recovery, DOAC: direct oral anticoagulant, locSVT: location of venous sinus thrombosis, ip: in preparation, IVIG: intravenous immunoglobulins, J: JNJ-78436735, M: mRNA-1273, ND: not discharged, nr: not reported, P: BNT126b2, PE: plasma exchange, PR: partial recovery at discharge or late follow-up (patient had not reached his pre-morbid condition), SSS: superior sagittal sinus, *: associated with immune thrombocytopenia

Back to article page