Fig. 1
From: An insight into Alzheimer’s disease and its on-setting novel genes
Alternative splicing of APP mRNA to produce 3 different isoforms of APP protein. The above diagram shows how alternative splicing of same amyloid precursor protein (APP) can produce different isoform of APP protein. The APP gene contains 19 exons, 170 kb end to end. The alternative splicing of exons 1 to 13, 13a, and 14 to 18 results in the isoforms. The isoform 695 is produced by the alternative splicing of exons 1–6, 9–18, excluding 13a, and APP 751 by exons 1–7, 9–18, excluding 13a. APP 770 is exons 1–18, excluding 13a