Association between microstructural white matter abnormalities and cognitive functioning in patients with type 2 diabetes mellitus: a diffusion tensor imaging study

Osama, Ahmed; Khalil, Tarek Hassan; Negm, Mohamed; AbdEl-Razek, Reda; AbouElhamd, Hend

doi:10.1186/s41983-020-00232-w

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery

Table 4 Fractional anisotropy and mean diffusivity of controls, diabetics without mild cognitive impairment, and diabetics with mild cognitive impairment

From: Association between microstructural white matter abnormalities and cognitive functioning in patients with type 2 diabetes mellitus: a diffusion tensor imaging study

		Control n = 30)	Diabetics		F	p	p₁	p₂	p₃
		Control n = 30)	Without MCI (n = 13)	With MCI (n = 17)	F	p	p₁	p₂	p₃
SLF FA	Right	0.48 ± 0.04	0.46 ± .047	0.40 ± .073	12.394*	< 0.001*	0.673	< 0.001*	0.005*
SLF FA	Left	0.47 ± 0.03	0.44 ± 0.04	0.38 ± 0.07	20.329*	< 0.001^*	0.147	< 0.001^*	0.002^*
ILF FA	Right	0.39 ± 0.05	0.48 ± 0.10	0.37 ± 0.04	12.293^*	< 0.001^*	< 0.001^*	0.442	< 0.001^*
ILF FA	Left	0.4 ± ±0.03	0.48 ± 0.10	0.33 ± 0.04	28.890^*	< 0.001^*	< 0.001^*	< 0.001^*	< 0.001^*
UNC FA	Right	0.43 ± 0.04	0.48 ± 0.12	0.39 ± 0.05	7.837^*	0.001^*	0.034^*	0.121	0.001^*
UNC FA	Left	0.42 ± 0.04	0.47 ± 0.10	0.34 ± 0.04	19.967^*	< 0.001^*	0.091	< 0.001^*	< 0.001^*
CCS FA	Right	0.44 ± 0.08	0.50 ± 0.08	0.38 ± 0.04	11.778^*	< 0.001^*	0.018^*	0.019^*	< 0.001^*
CCS FA	Left	0.41 ± 0.02	0.47 ± 0.11	0.33 ± 0.03	25.579^*	< 0.001^*	0.004^*	< 0.001^*	< 0.001^*
CCG FA	Right	0.40 ± 0	0.48 ± 0.10	0.38 ± 0.04	15.194^*	< 0.001^*	< 0.001^*	0.563	< 0.001^*
CCG FA	Left	0.44 ± 0.02	0.47 ± 0.11	0.34 ± 0.04	27.118^*	< 0.001^*	0.186	< 0.001^*	< 0.001^*
SLF MD	Right	0.70 ± 0.07	0.72 ± 0.10	0.79 ± 0.07	6.440*	0.003*	0.947	0.003*	0.033*
SLF MD	Left	0.7 ± ±0.08	0.73 ± 0.03	0.83 ± 0.08	15.162^*	0.001*	0.582	0.001*	0.002*
ILF MD	Right	0.74 ± 0.03	0.71 ± 0.07	0.80 ± 0.04	16.340^*	< 0.001^*	0.205	< 0.001^*	< 0.001^*
ILF MD	Left	0.75 ± 0.03	0.73 ± 0.09	0.84 ± 0.05	20.460^*	< 0.001^*	0.294	< 0.001^*	< 0.001^*
UNC MD	Right	0.75 ± 0.03	0.70 ± 0.07	0.79 ± 0.06	15.219^*	< 0.001^*	0.005^*	0.008^*	< 0.001^*
UNC MD	Left	0.75 ± 0.03	0.72 ± 0.08	0.83 ± 0.05	19.609^*	< 0.001^*	0.161	< 0.001^*	< 0.001^*
CCS MD	Right	0.76 ± 0.03	0.71 ± 0.06	0.79 ± 0.05	13.308^*	< 0.001^*	0.003^*	0.042^*	< 0.001^*
CCS MD	Left	0.77 ± 0.03	0.72 ± 0.06	0.82 ± 0.05	22.582^*	< 0.001^*	0.001^*	< 0.001^*	< 0.001^*
CCG MD	Right	0.76 ± 0.03	0.73 ± 0.04	0.79 ± 0.06	7.537^*	0.001^*	0.065	0.080	0.001^*
CCG MD	Left	0.74 ± 0.03	0.74 ± 0.05	0.82 ± 0.06	24.996^*	< 0.001^*	0.848	< 0.001^*	< 0.001^*

Data was expressed by using (mean ± SD), MCI mild cognitive impairment, F F for ANOVA test, pair wise comparison between each 2 groups was done using post hoc test (Tukey)
p₁ p value for comparing between control and diabetics without MCI
p₂ p value for comparing between control and diabetics with MCI
p₃ p value for comparing between diabetics without MCI and diabetics with MCI
*Statistically significant at p ≤ 0.05
UNC Uncinate, SLF superior longitudinal fasciculus, ILF inferior longitudinal fasciculus, CCS corpus callosum splenium, CCG corpus callosum genu, FA fractional anisotropy, MD mean diffusivity

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