Fig. 3
From: A p.Val412Serfs pathogenic variant associated with Wolfram-like syndrome and leukodystrophy
Spinal MRI. a Sagittal T2 image of the cervical spinal cord: syrinx cavity (yellow arrow) and brain stem lesions are also seen (white arrow), b sagittal T2 image of the thoracic spinal cord: syrinx cavity (yellow arrow). Brain Spectroscopy imaging: c sample on white matter lesion (blue square), d Choline(Cho), Cretininine (cr1) and N-acetyl aspartate (NAA) metabolites with nearly normal values, e cerebral blood volume map of brain perfusion imaging showing decreased white matter perfusion