Fig. 2
From: A p.Val412Serfs pathogenic variant associated with Wolfram-like syndrome and leukodystrophy
a T2 axial MR image: hyperintensity at periventricular white matter (white arrows), b contrast-enhanced T1 axial MR image: no contrast enhancement is seen at the same white matter lesions (white arrows), c coronal FLAIR (Fluid-Attenuated Inversion Recovery) MR image: same lesions on periventricular white matter (yellow arrows), d bilateral atrophic optic nerves (white arrows), e bilateral micro-ophthalmia (yellow arrows), f sagittal FLAIR image: atrophy and hyper-intensity on brainstem (white arrow), g diffusion restriction on diffusion-weighted image and h on ADC (apparent diffusion coefficient) map (arrows)