From: Genetic generalized epilepsy: factors associated with drug resistance polytherapy
Monotherapy | Polytherapy | P value | |||
---|---|---|---|---|---|
Count | % | Count | % | ||
Gender | |||||
Male | 169 | 46.0% | 128 | 48.7% | 0.516 |
Female | 198 | 54.0% | 135 | 51.3% | |
Febrile convulsions | |||||
Yes | 23 | 6.3% | 13 | 4.9% | 0.48 |
No | 344 | 93.7% | 250 | 95.1% | |
Family history | |||||
Yes | 48 | 13.1% | 32 | 12.2% | 0.735 |
No | 319 | 86.9% | 231 | 87.8% | |
Syndrome | |||||
CAE | 19 | 5.2% | 19 | 7.2% | 0.2 |
JAE | 82 | 22.3% | 75 | 28.5% | 0.02 |
JME | 193 | 52.6% | 121 | 46.0% | 0.1 |
GTCs only | 64 | 17.4% | 31 | 11.8% | 0.06 |
MAS | 7 | 1.9% | 12 | 4.6% | 0.1 |
Myoclonic absence | 2 | 0.5% | 5 | 1.9% | 0.02 |
No. of seizure types | |||||
1 | 109 | 29.7% | 59 | 22.4% | < 0.001 |
2 | 233 | 63.5% | 153 | 58.2% | |
3 | 25 | 6.8% | 51 | 19.4% | |
Absence seizure | |||||
Yes | 120 | 32.7% | 140 | 53.2% | < 0.001 |
No | 247 | 67.3% | 123 | 46.8% | |
Myoclonic seizure | |||||
Yes | 214 | 58.3% | 154 | 58.6% | 0.951 |
No | 153 | 41.7% | 109 | 41.4% | |
GTCs | |||||
Yes | 316 | 86.1% | 224 | 85.2% | 0.742 |
No | 51 | 13.9% | 39 | 14.8% | |
Nocturnal seizures | |||||
Yes | 39 | 10.6% | 61 | 23.2% | < 0.001 |
No | 328 | 89.4% | 202 | 76.8% | |
Clusters | |||||
Yes | 23 | 6.3% | 37 | 14.1% | 0.001 |
No | 344 | 93.7% | 226 | 85.9% | |
Catamenial seizures (females) | |||||
Yes | 4 | 2.0% | 14 | 10.4% | 0.002 |
No | 194 | 98.0% | 121 | 89.6% | |
H\O CAE | |||||
Yes | 8 | 2.2% | 14 | 5.3% | 0.034 |
No | 359 | 97.8% | 249 | 94.7% | |
NCSE | |||||
Yes | 6 | 1.6% | 11 | 4.2% | 0.052 |
No | 361 | 98.4% | 252 | 95.8% | |
Status epilepticus | |||||
Yes | 2 | 0.5% | 3 | 1.1% | 0.654 |
No | 365 | 99.5% | 260 | 98.9% | |
Focal semiology | |||||
Yes | 16 | 4.4% | 19 | 7.2% | 0.122 |
No | 351 | 95.6% | 244 | 92.8% | |
Psychiatric comorbidities | |||||
Yes | 35 | 9.5% | 27 | 10.3% | 0.762 |
No | 332 | 90.5% | 236 | 89.7% | |
Sleep deprivation-induced seizures | |||||
Yes | 81 | 22.1% | 72 | 27.4% | 0.126 |
No | 286 | 77.9% | 191 | 72.6% | |
EEG focal features | |||||
Yes | 21 | 5.7% | 31 | 11.8% | 0.006 |
No | 346 | 94.3% | 232 | 88.2% | |
Active EEGs | |||||
Yes | 56 | 15.3% | 66 | 25.1% | 0.002 |
No | 311 | 84.7% | 197 | 74.9% | |
Photoparoxysmal response | |||||
Yes | 10 | 2.7% | 5 | 1.9% | 0.504 |
No | 357 | 97.3% | 258 | 98.1% | |
OFF medication last visit | |||||
Yes | 51 | 13.9% | 18 | 6.8% | 0.005 |
No | 316 | 86.1% | 245 | 93.2% | |
Achievement of at least 5 years remission on AEDs | |||||
Yes | 251 | 76.8% | 121 | 52.8% | < 0.001 |
No | 76 | 33.2% | 108 | 47.1% | |
Achievement of at least 5 years remission off AEDs | |||||
Yes | 45 | 13.8% | 10 | 4.4% | 0.001 |
No | 282 | 86.2% | 219 | 95.6% |