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Table 2 Distribution of depression, anxiety, and cognitive function among non-cirrhotic and control groups

From: Impact of direct-acting antivirals on neuropsychiatric and neurocognitive dysfunction in chronic hepatitis C patients

Variables

Pre-treated (n = 20)

Post-treated (n = 20)

Controls (n = 10)

Pre-treated versus controls

Pre-treated versus post-treated

Post-treated versus controls

T value

P value

T value

P value

T value

P value

HDS

6.5 ± 2.1

2.6 ± 1.7

1.2 ± 0.4

7.749

 < 0.001

6.450

 < 0.001

2.510

0.031

HAS

5.8 ± 1.4

1.7 ± 0.4

1 ± 0.3

9.000

 < 0.001

6.082

 < 0.001

1.413

0.175

Long-term memory

7.5 ± 2.1

7.8 ± 2.3

9 ± 1.7

1.772

0.093

1.964

0.081

1.327

0.201

Short-term memory

4.4 ± 1.2

5.6 ± 1.4

7 ± 1.7

3.888

0.001

4.609

0.001

2.015

0.06

Attention

6.7 ± 1.3

6.6 ± 1.7

7.3 ± 1.5

0.973

0.343

0.214

0.835

1.034

0.315

Concentration

3.4 ± 1.3

4.7 ± 1.5

4.6 ± 1.8

1.664

0.113

2.512

0.033

0.133

0.895

Orientation

14.8 ± 4.02

15.1 ± 3.9

16 ± 3.2

0.735

0.472

1.000

0.343

0.562

0.581

Language

8 ± 1.8

8.2 ± 1.8

9.1 ± 1.4

1.492

0.153

1.000

0.343

1.226

0.236

Visual construction/ drawing

5.7 ± 3.4

6.4 ± 2.8

7.8 ± 3.5

1.376

0.186

1.909

0.089

0.995

0.333

List generation fluency

7.3 ± 2.2

7 ± 1.6

7.5 ± 1.8

0.223

0.826

0.758

0.468

0.655

0.521

Abstract thinking and judgment

6.5 ± 1.4

7.7 ± 1.9

9.3 ± 1.9

3.734

0.002

2.714

0.024

1.894

0.07

Total CASI

62.3 ± 13.5

65.9 ± 12.1

77.6 ± 13.8

3.132

0.012

3.870

0.001

2.020

0.06

  1. Values are presented as mean ± standard deviation or n (%). T-value for Student’s t-test. P-value < 0.05 is significant
  2. CASI: Cognitive Abilities Screening Instruments, HAS: Hamilton Anxiety Score, HDS: Hamilton Depression Score
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