Table 1 Detailed participants for each outcomes including their quality of evidence

Brain Relaxation*

745

⨁⨁⨁◯

OR 1.84

67 per 100

12 more per 100

(10 RCTs)

Moderate^a

(1.31 to 2.59)

(6 more to 17 more)

Total urine output*

615

⨁⨁⨁◯

–

–

SMD 0.75 SD lower

(7 RCTs)

Moderate^b

(0.92 lower to 0.22 lower)

Serum osmolality

164

⨁◯◯◯

–

The mean serum osmolality was 296.6 mOsm/L

MD 1.97 mOsm/L higher

(3 RCTs)

Very low^b,c

(3.05 lower to 7 higher)

Arterial sodium*

328

⨁⨁◯◯

–

The mean arterial sodium was 132 mmol/L

MD 12.69 mmol/L higher

(3 RCTs)

Low^b,c

(10.85 higher to 14.53 higher)

Serum sodium*

253

⨁⨁⨁◯

–

The mean serum sodium was 138 mmol/L

MD 4.5 mmol/L higher

(5 RCTs)

Moderate^c

(3.65 higher to 5.35 higher)

Fluid input*

576

⨁⨁⨁◯

–

–

SMD 0.56 SD lower

(6 RCTs)

Moderate^b

(0.98 lower to 0.15 lower)

Max MAP

139

⨁◯◯◯

–

The mean max MAP was 84.7 mmHg

MD 1.83 mmHg higher

(3 RCTs)

Very low^b,c

(1.54 lower to 5.2 higher)

Max CVP

263

⨁⨁◯◯

–

The mean max CVP was 8.6 mmHg

MD 0.56 mmHg higher

(RCTs)

Low^c,d

(0.68 lower to 1.8 higher)