Functional outcomes of extended-release methylphenidate and atomoxetine in children: retrospective chart analysis

Table 1 Descriptive statistics for two groups in the baseline

	OROS-MPH (n = 238)	ATX (n = 137)	Statistics	p
Demographics
Age	9.29 ± 2.30	9.51 ± 2.33	t = − 0.908	0.919
Sex			χ² = 0.243	0.622
Female	100 (42%)	54 (39.4%)
Male	138 (58%)	83 (60.4%)
Hollingshead Index (mean of both parents total score)	3.88 ± 2.37	3.97 ± 2.31	t = − 0.354	0.723
ADHD subtype			χ² = 0.587	0.746
Inattentive	113 (47.5%)	69 (50.4%)
Hyperactive/impulsive	20 (8.4%)	13 (9.5%)
Combined	105 (44.1%)	55 (40.1%)
ODD	53 (22.3%)	26 (19%)	χ² = 0.566	0.452
CD	92 (%38.7)	58 (%42.3)	χ² = 0.491	0.484
AP usage	39 (%16.4)	21 (%15.3)	χ² = 0.072	0.788
AD usage	14 (%5.9)	7 (%5.1)	χ² = 0.098	0.754
T-DSM-IV-S
Total	35.80 ± 2.60	35.72 ± 2.71	t = 0.267	0.790
Inattention	21.53 ± 4.21	21.20 ± 4.69	t = 0.690	0.491
H/I	14.27 ± 4.38	14.22 ± 4.50	t = -0.526	0.600
Opposition-defiance	7.72 ± 5.82	7.02 ± 5.19	t = 1.158	0.247
Conduct disorder	4.22 ± 2.90	4.56 ± 2.99	t = -1.091	0.276
WFIRS-P
Total	1.29 ± 0.32	1.32 ± 0.35	t = -0.966	0.335
Family	1.40 ± 0.84	1.32 ± 0.79	t = 0.915	0.361
School	1.51 ± 0.86	1.59 ± 0.86	t = -0.881	0.379
Learning***	1.85 ± 0.94	1.47 ± 0.97	t = 3.668	< 0.001
Behavior***	1.27 ± 0.89	1.65 ± 0.87	t = -3.973	< 0.001
Life skills	1.47 ± 0.85	1.57 ± 0.84	t = -1.052	0.294
Self-concept	0.51 ± 0.42	0.53 ± 0.37	t = -0.453	0.651
Social activities	1.44 ± 0.85	1.43 ± 0.83	t = 0.057	0.954
Risky activities	0.90 ± 0.85	0.98 ± 0.59	t = -1.216	0.225

ADHD attention-deficit/hyperactivity disorder, AP antipsychotics, AD antidepressants, ATX atomoxetine, CD conduct disorder, H/I hyperactivity–impulsivity, ODD oppositional defiant disorder, OROS-MPH osmotic-release oral delivery system methylphenidate, T-DSM-IV-S the Turgay DSM-IV Disruptive Behavior Disorders Rating Scale, WFIRS-P Weiss Functional Impairment Rating Scale-Parent Report