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Table 2 Let-7 miRNAs expression (in fold change) in the studied groups

From: Effect of Letrozole on hippocampal Let-7 microRNAs and their correlation with working memory and phosphorylated Tau protein in an Alzheimer's disease-like rat model

Groups

Parameter

Let-7a fold change

Mean ± SD

Median

Range

Let-7b fold change

Mean ± SD

Median

Range

Let-7e fold change

Mean ± SD

Median

Range

Negative control (n = 6)

1.30 ± 1a

0.87

0.46–2.59

1.55 ± 1.34a

1.29

0.2–3.63

1.94 ± 1.74a

1.75

0.9–4

CSF (n = 6)

1.60 ± 1a

1.57

0.67–2.57

1.8 ± 1.24a

1.92

0.52–2.99

1.56 ± 0.74a

1.89

0.62–2.36

LV (n = 6)

1.35 ± 0.43a

1.18

0.95–1.9

1.52 ± 0.32a

1.53

1.16–1.88

1.70 ± 1.20a

1.86

0.35–2.91

CSF-LV (n = 6)

1.26 ± 2.45a

0.21

0.17–6.25

0.84 ± 0.82a

0.43

0.34–2.41

1.35 ± 2.35a

0.41

0.11–6.11

STZ (n = 9)

0.97 ± 0.84a

0.64

0.06–2.45

1.89 ± 1.41a

1.81

0.39–4.85

2.35 ± 1.60a

2.91

0.47–5.54

Letrozole (n = 9)

4.70 ± 2.07b

5.18

0.8–7.85

6.47 ± 3.39b

5.85

1.07–12.37

9.01 ± 5.12b

7.36

2.89–17.27

STZ-L (n = 9)

5.91 ± 3.94b

4.8

3.1–14.25

5.93 ± 2.66b

4.82

3.16–10.11

9.29 ± 6.28b

7.73

3.2–19.97

KW

29.89

30.24

31.35

P

< 0.001**

< 0.001**

< 0.001**

  1. KW: Kruskal–Wallis test, **Highly significant (P < 0.01)
  2. Groups with different letters have statistically significant (P < 0.05) differences