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Table 1 In vivo studies of GDF11

From: Potential role of recombinant growth differentiation factor 11 in Alzheimer’s disease treatment

Dosage

Time

Sample

Results

 

40 ng/mL

6 days

15-month-old mice

Brain cells neurogenesis and angiogenesis

[54]

1 mg/kg

28 days

22-month-old mice

Neural activation and angiogenesis

[19]

0.1 mg/kg

1 day

9-month-old mice

Neurogenesis and increase short-term memory

[55]

40 ng/mL

1 day

Cell migration and angiogenesis

[56]

0.1 mg/kg

13 days

10-week-old mice

Elevated neuronal precursor cells, microvascular length and area, and brain capillary perfusion

[57]

0.1 mg/kg

28 days

12-month-old mice

Rejuvenated cognitive function, angiogenesis and elevate Aβ burden

[13]