From: Potential role of recombinant growth differentiation factor 11 in Alzheimer’s disease treatment
Dosage | Time | Sample | Results | |
---|---|---|---|---|
40 ng/mL | 6 days | 15-month-old mice | Brain cells neurogenesis and angiogenesis | [54] |
1 mg/kg | 28 days | 22-month-old mice | Neural activation and angiogenesis | [19] |
0.1 mg/kg | 1 day | 9-month-old mice | Neurogenesis and increase short-term memory | [55] |
40 ng/mL | 1 day | – | Cell migration and angiogenesis | [56] |
0.1 mg/kg | 13 days | 10-week-old mice | Elevated neuronal precursor cells, microvascular length and area, and brain capillary perfusion | [57] |
0.1 mg/kg | 28 days | 12-month-old mice | Rejuvenated cognitive function, angiogenesis and elevate Aβ burden | [13] |