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Fig. 1 | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery

Fig. 1

From: Advances in targeting central sensitization and brain plasticity in chronic pain

Fig. 1

Nociceptive pathways and the main loci of maladaptive plasticity. Activation of peripheral nociceptors generates action potentials that are transmitted to secondary afferents in the dorsal horn, which then project to the brain for processing. Particularly intense tissue insults result in maladaptive plasticity including peripheral sensitization in primary afferents, central sensitization in dorsal horn secondary afferents and brain remodeling. AP action potential, AMPAR 3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor, DRG dorsal root ganglion, Glu glutamate, mGluR metabotropic glutamate receptor, NK1 neurokinin receptor, NMDAR N-methy-d-aspartate receptor, PKA/PKC protein kinase A/C, SP substance-P, VGCC voltage-gated calcium channel

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