Skip to main content

Table 2 Effect of test drugs on BDNF in hippocampus and oxidative stress markers in hippocampus and femur bone, of ketamine treated rats

From: Effects of tamoxifen alone and in combination with risperidone on hyperlocomotion, hippocampal structure and bone in ketamine-induced model of psychosis in rats

Animal groups

n = 10

BDNF hippocampus

ng/g tissue

Oxidative stress markers

Hippocampus

Bone

GSH

pg/g

tissue

MDA

ng/g

tissue

GSH

pg/g

tissue

MDA

ng/g

tissue

Control non-ketamine treated

10.2 ± 0.31

10.55 ± 0.42

1.6 ± 0.2

6.5 ± 0.35

1.49 ± 0.15

Control/ketamine

1.94 ± 0.1*

1.54 ± 0.18*

10.93 ± 0.5*

3.28 ± 0.19*

5.2 ± 0.25*

TAM/ketamine

6.35 ± 0.34*,#,ɫ

5.5 ± 0.25*,#,ɫ

4.5 ± 0.5*,#,ɫ

5.66 ± 0.29#,ɫ

2.26 ± 0.1#,ɫ

Risp/ketamine

4.8 ± 0.22*,#

3.6 ± 0.22*,#

7.03 ± 0.48*,#

0.88 ± 0.15*,#

7.5 ± 0.29*,#

TAM/Risp/ketamine

7.66 ± 0.25*,#,ɫ

7.8 ± 0.33*,#,ɫ

4.6 ± 0.25*,#,ɫ

5.01 ± 0.3*#,ɫ

3.19 ± 0.133*,#,ɫ

  1. Data are expressed as mean ± SEM, n number of rats. Two way ANOVA followed by Tukey multiple comparison tests
  2. Tam tamoxifen, Risp risperidone, BDNF brain derived neurotrophic factor, GSH reduced glutathione, MDA malondialdehyde
  3. *p < 0.05 significant compared to control non-ketamine treated
  4. #p < 0.05 significant drug treated/ketamine compared to control/ketamine
  5. ɫp < 0.05 significant compared to Risp/ketamine treated