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Table 1 Effects of test drugs on the number of crossed squares in the open field test in ketamine treated rats

From: Effects of tamoxifen alone and in combination with risperidone on hyperlocomotion, hippocampal structure and bone in ketamine-induced model of psychosis in rats

Animal groups

n = 10 each

Open field test (no. of crossed squares)

Control non-ketamine treated

51.3 ± 6.7

Control ketamine treated

83.4 ± 14.2*

TAM/ketamine treated

49.6 ± 6.4#

Risp/ketamine treated

33 ± 3*,#

TAM/Risp/ketamine treated

18 ± 2.5*,#,ɫ

Clomiphene/ketamine treated

84 ± 2.6*

Clomiphene/Risp/ketamine treated

30 ± 3*,#

  1. Data are expressed as mean ± SEM, n number of rats, two-way ANOVA followed by Tukey multiple comparison tests
  2. Tam tamoxifen, Risp risperidone
  3. *p < 0.05 significant compared to control non-ketamine treated
  4. #p < 0.05 significant drug treated ketamine compared to control ketamine treated rats
  5. ɫp < 0.05 combination compared to risperidone/ketamine treated