Table 3 Comparison between patients in different disability groups according to EDSS
No disability N = 28 | Minimal disability N = 32 | Moderate disability N = 20 | P value | |
|---|---|---|---|---|
Age (year) mean ± SD | 35.7 ± 10.1 | 30.7 ± 6.6 | 33.6 ± 8.6 | 0.081 |
Sex | 0.011 | |||
Male | 12 (42.9%) | 20 (62.5%) | 4 (20.0%) | |
Female | 16 (57.1%) | 12 (37.5%) | 16 (80.0%) | |
Duration (years) | 1.6 ± 2.2 | 6.2 ± 5.1 | 6.3 ± 4.5 | < 0.001 |
Number of attacks/years | 2 ± 0.5 | 3 ± 1.2 | 3.4 ± 0.5 | < 0.001 |
Disease modifying therapy | 0.000 | |||
No | 24 (85.7%) | 12 (37.5%) | 16 (80.0%) | |
Yes | 4 (14.3%) | 20(62.5%) | 4 (20.0%) | |
Symptomatic treatment | 0.000 | |||
No | (57.1%) | 4 (12.5%) | 0 (0.0%) | |
Yes | 12 (42.9%) | 28 (87.5%) | 20 (100.0%) | |
Conventional MRI (cMRI) | ||||
Number of plaques on T2 weighted images | 4 ± 1.3 | 7 ± 3.9 | 6.4 ± 3.5 | 0.001 |
Black holes | 2.8 ± 1.2 | 4 ± 2.1 | 2.4 ± 3.4 | 0.037 |
Enhanced plaques | 12(42.9%) | 0(0.0%) | 12(60.0%) | < 0.001 |
Non-conventional MRI | ||||
ADC | 1.12 ± 0.19 | 1.50 ± 0.35 | 1.51 ± 0.36 | < 0.001 |
NAA/Cr NAWM | 1.67 ± 0.03 | 1.6 ± 0.45 | 1.49 ± .033 | 0.297 |
NAA/Cr plaque | 1.34 ± 0.44 | 1.59 ± 0.51 | 1.11 ± 0.15 | 0.001 |
Cho/NAA_NAWM | 0.65 ± 0.07 | 0.69 ± .082 | 0.67 ± 0.08 | 0.094 |
Cho/NAA plaque | 0.72 ± 0.08 | 0.71 ± 0.10 | 0.74 ± 0.06 | 0.580 |
Cho/Cr NAWM | 1.05 ± 0.48 | 0.98 ± 0.16 | 0.98 ± 0.13 | 0.636 |
Cho/Cr plaque | 1.15 ± 0.42 | 1.03 ± 0.21 | 1.07 ± 0.21 | 0.296 |