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Table 1 The natural history of multiple sclerosis: a geographically based study 9: observations on the progressive phase of the disease

From: Correlation between functional MRI techniques and early disability in ambulatory patients with relapsing–remitting MS

 

Number

Percent

Age

33.20 ± 8.6

 

Sex

  

 Male

36

45.0

 Female

44

55.0

Clinical features

  

 Duration of disease (years)

4.6 ± 4.6

 

 Number of MS attacks/year

2.75 ± 1.049

 

 Duration of last attack (months)

3.3 ± 3

 

Disability score (EDSS)

  

 No disability

28

35.0

 Minimal

32

40.0

 Moderate disability

20

25.0

Disease modifying therapy (DMT)

  

 No

52

65.0

 Yes

28

35.0

 Male patients taking DMT

16

44.4%

 Female patients taking DMT

12

27.3%

Symptomatic treatment

  

 No

20

25.0

 Yes

60

75.0

Conventional MRI finding

  

 Number of plaques on T2 weighted images

5.80 ± 3.421

 

 Black holes

3.2 ± 2.3

 

 Enhanced plaques

24

30.0

 Non enhanced plaques

56

70.0

Non-conventional MRI finding

  

 ADC

1.37 ± 0.361

 

 NAA/Cr NAWM

1.6 ± 0.40

 

 NAA/Cr plaque

1.3 ± 0.46

 

 Cho/NAA NAWM

0.67 ± 0.08

 

 Cho/NAA plaque

0.72 ± 0.08

 

 Cho/Cr NAWM

1.01 ± 0.30

 

 Cho/Cr plaque

1.08 ± 0.31

 
  1. Cho/Cr choline/creatine; Cho/NAA choline/N-acetyl-aspartate; DMT disease modifying therapy; EDSS expanded disability status scale; NAA/Cr N-acetyl-aspartate/creatine; NAWM normal appearing white matter