Baseline predictors of progression of Parkinson’s disease in a sample of Egyptian patients: clinical and biochemical

Table 4 Correlations between progression of motor and physical activity with baseline cognitive, NMSS and quality of life

Mean difference between baseline and 1-year follow-up		Baseline MMSE^a	Baseline NMSS total score	Baseline BDI	Baseline PDQ-39	Baseline IPAQ	Baseline LEDD
Δ MDS-UPDRS total score OFF	Pearson	0.046	− 0.376*	− 0.220	− 0.211	0.125	− 0.133
	Sig	0.765	0.012	0.152	0.170	0.420	0.391
Δ Axial OFF^a	Spearman	− 0.039	− 0.392	− 0.298	− 0.298	0.231	− 0.125
Δ Axial OFF^a	Sig	0.802	0.009	0.049	0.050	0.131	0.418
Δ PIGD OFF^a	Spearman	− 0.102	− 0.371	− 0.289	− 0.222	0.152	− 0.115
Δ PIGD OFF^a	Sig	0.510	0.013	0.057	0.148	0.325	0.459
Δ Motor complication total score^a	Spearman	0.002	− 0.225	− 0.360	− 0.116	0.379	0.006
Δ Motor complication total score^a	Sig	0.991	0.141	0.017	0.454	0.011	0.971
Δ Hoehn and Yahr OFF^a	Spearman	− 0.048	0.118	0.172	0.186	− 0.052	0.171
Δ Hoehn and Yahr OFF^a	Sig	0.756	0.444	0.264	0.227	0.736	0.268
Δ Schwab and England ADL OFF^a	Spearman	− 0.399	0.302	0.302	0.426	− 0.207	0.259
Δ Schwab and England ADL OFF^a	Sig	0.007	0.046	0.046	0.004	0.178	0.089
Δ IPAQ	Pearson	0.002	− 0.028	− 0.228	− 0.075	0.675**	− 0.114
Δ IPAQ	Sig	0.988	0.855	0.137	0.631	< 0.001	0.461

Bold values are significant
MDS-UPDRS Movement Disorder Society—Unified Parkinson’s Disease Rating Scale PIGD postural instability and gait disorder, ADL activities of daily living, IPAQ International Physical Activity Questionnaire, MMSE Mini-Mental State Examination, NMSS Non-Motor Symptoms Scale, BDI Beck Depression Inventory, PDQ_39 Parkinson’s Disease Questionnaire-39
^*p value is significant if < 0.05
^**After Bonferroni correction, p value is significant if < 0.003