Baseline predictors of progression of Parkinson’s disease in a sample of Egyptian patients: clinical and biochemical

Table 3 Correlations between progression of motor and physical activity with baseline demographic and clinical characteristics

Mean difference between baseline and 1-year follow-up		Age	AOO^a	DOI^a	Baseline MDS-UPDRS-OFF-Total score	Baseline MDS-UPDRS-III	Baseline PIGD OFF^a	Baseline Hoehn and Yahr OFF^a	Baseline TUG OFF^a	Baseline NFOG-Q OFF^a
Δ MDS-UPDRS total score OFF	Pearson	− 0.024	− 0.060	0.073	− 0.170	− 0.045	− 0.029	0.152	0.078	− 0.025
	Sig	0.876	0.698	0.640	0.269	0.773	0.851	0.324	0.614	0.874
Δ Axial OFF^a	Spearman	0.059	0.024	− 0.015	− 0.168	− 0.143	− 0.172	0.011	0.070	− 0.016
Δ Axial OFF^a	Sig	0.702	0.879	0.923	0.275	0.355	0.263	0.945	0.652	0.918
Δ PIGD OFF^a	Spearman	− 0.033	− 0.053	0.010	− 0.110	− 0.044	− 0.226	0.078	0.117	− 0.047
Δ PIGD OFF^a	Sig	0.830	0.734	0.951	0.476	0.775	0.140	0.616	0.450	0.764
Δ Motor complication total score^a	Spearman	− 0.186	− 0.281	0.084	− 0.194	− 0.095	− 0.183	− 0.193	− 0.273	− 0.137
Δ Motor complication total score^a	Sig	0.227	0.065	0.586	0.208	0.539	0.234	0.210	0.073	0.375
Δ Hoehn and Yahr OFF^a	Spearman	0.006	− 0.102	0.367	0.204	0.157	0.284	0.181	0.319	0.252
Δ Hoehn and Yahr OFF^a	Sig	0.970	0.509	0.014	0.184	0.309	0.062	0.239	0.035	0.099
Δ Schwab and England ADL OFF^a	Spearman	0.098	− 0.042	0.337	0.478	0.350	0.591	0.401	0.565	0.498
Δ Schwab and England ADL OFF^a	Sig	0.526	0.785	0.025	0.001	0.020	< 0.001	0.007	< 0.001	0.001
Δ IPAQ	Pearson	0.055	0.199	− 0.222	− 0.073	− 0.045	− 0.110	0.110	− 0.042	− 0.231
Δ IPAQ	Sig	0.725	0.195	0.148	0.639	0.773	0.477	0.478	0.788	0.131

Bold values are significant
AOO age of onset, DOI duration of illness, LEDD levodopa equivalent daily dose, MDS-UPDRS Movement Disorder Society—Unified Parkinson’s Disease Rating Scale, PIGD postural instability and gait disorder, ADL activities of daily living, IPAQ International Physical Activity Questionnaire
^aSpearman’s correlation was used
^*p value is significant if < 0.05
^**After Bonferroni correction, p value is significant if < 0.003